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13 results for "PI 3-Kinase Inhibitors" in Products

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PI 3-Kinase Inhibitors

PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation, cell survival, degranulation, vesicular trafficking and cell migration.

The PI 3-kinases are grouped into three distinct classes. Class I PI 3-kinases are heteromeric consisting of a regulatory subunit and a 110 kDa catalytic subunit (3 ...

LY 294002 hydrochloride

Catalog #: 1130

(7)

Citations (107)

Product Documents

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Chemical Name:	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity:	≥99%

Wortmannin

Catalog #: 1232

(2)

Citations (308)

Product Documents

Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1

Alternate Names:	SL-2052
Chemical Name:	(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione
Purity:	≥98%

Quercetin

Catalog #: 1125

Product Documents

Non-selective PI 3-kinase inhibitor

Chemical Name:	2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
Purity:	≥98%

PI 103 hydrochloride

Catalog #: 2930

Product Documents

Inhibitor of PI 3-kinase, mTOR and DNA-PK

Chemical Name:	3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride
Purity:	≥98%

PI 828

Catalog #: 2814

(1)

Product Documents

PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)

Chemical Name:	2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
Purity:	≥98%

3-Methyladenine

Catalog #: 3977

Product Documents

Class III PI 3-kinase inhibitor; also inhibits autophagy

Alternate Names:	3-MA
Chemical Name:	3-Methyl-3H-purin-6-amine
Purity:	≥98%

A66

Catalog #: 5595

Product Documents

Potent and selective PI 3-kinase p110α inhibitor

Chemical Name:	(2S)-N¹-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
Purity:	≥98%

Urolithin A

Catalog #: 6762

Product Documents

PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Chemical Name:	3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one
Purity:	≥98%

AZD 6482

Catalog #: 4839

Product Documents

Potent and selective PI 3-Kβ inhibitor

Chemical Name:	(-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
Purity:	≥98%

Omipalisib

Catalog #: 6792

Product Documents

Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK

Alternate Names:	GSK2126458
Chemical Name:	2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
Purity:	≥98%

Idelalisib

Catalog #: 7631

Product Documents

Potent PI 3-Kinase δ isoform inhibitor

Chemical Name:	5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone
Purity:	≥98%

PIK 90

Catalog #: 7902

Product Documents

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

Chemical Name:	N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide
Purity:	≥98%

GDC 0941

Catalog #: 8905

Product Documents

Potent pan-class I PI3 kinase inhibitor

Chemical Name:	2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
Purity:	≥98%

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