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12 results for "Protein Ser/Thr Phosphatase Inhibitors" in Products

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Protein Ser/Thr Phosphatase Inhibitors

Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways.

There are two groups of serine/threonine phosphatases: phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid; and metallo-phosphatases (e.g. ...

Cyclosporin A

Catalog #: 1101

(1)

Citations (115)

Product Documents

Calcineurin inhibitor

Alternate Names:	Ciclosporin A
Purity:	≥98%

Salubrinal

Catalog #: 2347

Citations (95)

Product Documents

Selective inhibitor of eIF2α dephosphorylation

Chemical Name:	3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Purity:	≥98%

FK 506

Catalog #: 3631

(2)

Citations (142)

Product Documents

Potent calcineurin inhibitor; immunosuppressant

Alternate Names:	Tacrolimus,Fujimycin
Chemical Name:	(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
Purity:	≥98%

Calyculin A

Catalog #: 1336

(1)

Citations (53)

Product Documents

Protein phosphatase 1 and 2A inhibitor

Chemical Name:	N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide
Purity:	≥90%

NFAT Inhibitor

Catalog #: 3930

Citations (12)

Product Documents

Inhibitor of calcineurin-mediated NFAT activation

Alternate Names:	VIVIT peptide
Purity:	≥95%

Sanguinarine chloride

Catalog #: 2302

Citations (13)

Product Documents

Inhibitor of protein phosphatase 2C (PP2C)

Chemical Name:	13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride
Purity:	≥97%

Sal 003

Catalog #: 3657

Citations (14)

Product Documents

Cell-permeable inhibitor of eIF2α dephosphorylation

Chemical Name:	3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Purity:	≥98%

GSK 2830371

Catalog #: 5140

Citations (6)

Product Documents

Potent and selective allosteric inhibitor of Wip1 phosphatase

Chemical Name:	5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide
Purity:	≥98%