52 results for "Smoothened" in Products
Smoothened Products
Smoothened, a Frizzled Receptor, is homologous to the Drosophila segment polarity Smo gene. It associates with the Patched protein to mediate the cellular response to the Hedgehog secreted protein signal, which controls patterning and growth during vertebrate development. Smoothened is activated in a number of human tumors and can function as an oncogene in basal-cell carcinomas. Smoothened expression has been documented in bladder, blood, brain, the central nervous system, skin, and ureter. ESTs have been isolated from amnion, bone, brain, breast, embryo, eye, heart, nerve, and skin libraries.
Inhibitor of Hedgehog (Hh) signaling
| Chemical Name: | (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol |
| Purity: | ≥97% |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #1015418 |
| Applications: | IHC |
| Reactivity: | Human, Mouse, Rat, Porcine, Bat, +6 More |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunohistochemistry-Paraffin: Smoothened Antibody - BSA Free [NLS2666]](https://resources.rndsystems.com/images/products/Smoothened-Antibody-Immunohistochemistry-Paraffin-NLS2666-img0003.jpg "Immunohistochemistry-Paraffin: Smoothened Antibody - BSA Free [NLS2666]")
Dihydrochloride salt of SAG; Smo receptor agonist
| Chemical Name: | 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride |
| Purity: | ≥98% |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA |
![Western Blot: Smoothened Antibody [NBP3-06699]](https://resources.rndsystems.com/images/products/Smoothened-Antibody-Western-Blot-NBP3-06699-img0003.jpg "Western Blot: Smoothened Antibody [NBP3-06699]")
High affinity and selective Smoothened (Smo) receptor antagonist
| Chemical Name: | 1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride |
| Purity: | ≥98% |
Potent Smo antagonist
| Chemical Name: | N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide] |
| Purity: | ≥98% |
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)
| Chemical Name: | 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one |
| Purity: | ≥98% |
Potent Smo antagonist
| Alternate Names: | glasdegib,PF-913 |
| Chemical Name: | 1-((2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate salt |
| Purity: | ≥98% |
| Reactivity: | Human |
Potent Smoothened receptor antagonist
| Chemical Name: | rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide |
| Purity: | ≥98% |
| Reactivity: | Human |
| Source: | Wheat germ |
| Applications: | WB, ELISA, AP, MA, PAGE |
![SDS-PAGE: Recombinant Human Smoothened GST (N-Term) Protein [H00006608-Q01]](https://resources.rndsystems.com/images/products/qc_test-H00006608-Q01-1.jpg "SDS-PAGE: Recombinant Human Smoothened GST (N-Term) Protein [H00006608-Q01]")
| Reactivity: | Human |
| Source: | Wheat germ |
| Applications: | WB, ELISA, AP, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #1015418 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #1015418 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #1015418 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #1015418 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #1015418 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #1015418 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #1015418 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #1015418 |
| Applications: | IHC |
| Reactivity: | Human |
| Applications: | WB |
![Western Blot: Smoothened Overexpression Lysate [NBP2-10451]](https://resources.rndsystems.com/images/products/Smoothened-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-10451-img0001.jpg "Western Blot: Smoothened Overexpression Lysate [NBP2-10451]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Source: | Wheat germ |
| Applications: | AP |
