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Proteome Profiler Human Apoptosis Array Kit

ARY009 64 Citations 10 Reviews Datasheet / COA / SDS
Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies
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ARY009
R&D Systems Proteome Profiler Antibody Array Kits
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Proteome Profiler Human Apoptosis Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of human apoptosis-related proteins. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects 35 human apoptosis-related proteins simultaneously
  • Requires no specialized equipment

ARY009 Data Examples
View Data Examples

 

Principle of the Assay

The Proteome Profiler Human Apoptosis Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Captured proteins are detected with biotinylated detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of the bound analyte.

Why Use an Antibody Array to Detect Apoptosis-Related Proteins?

Determining the expression of multiple proteins in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple proteins in a single sample can be cost-effective and also save time and sample.

 

Kit Contents
  • 4 Array Membranes
  • 4-Well Multi-dish
  • Array Buffers
  • Lysis Buffer
  • Wash Buffer
  • Antibody Detection Cocktail
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed Protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.

 
Simultaneously detect the relative levels of these apoptosis-related proteins in a single sample.
Bad TRAIL R1/DR4 PON2
Bax TRAIL R2/DR5 p21/CIP1/CDNK1A
Bcl-2 FADD p27/Kip1
Bcl-x Fas/TNFSF6 Phospho-p53 (S15)
Pro-Caspase-3 HIF-1 alpha Phospho-p53 (S46)
Cleaved Caspase-3 HO-1/HMOX1/HSP32 Phospho-p53 (S392)
Catalase HO-2/HMOX2 Phospho-Rad17 (S635)
cIAP-1 HSP27 Pro-Caspase-3
cIAP-2 HSP60 SMAC/Diablo
Claspin HSP70 Survivin
Clusterin HTRA2/Omi TNF RI/TNFRSF1A
Cytochrome c Livin XIAP

 

Assays for analytes represented in the Human Apoptosis Array Kit

Analyte Quantikine® ELISA Kits DuoSet® ELISA Development Systems DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA Development Systems (Phospho or Active)
Bad     DYC819  
Bax     DYC820  
Bcl-2     DYC827B  
Bcl-x        
Pro-Caspase-3        
Cleaved Caspase-3 KM300   DYC835  
Catalase        
cIAP-1        
cIAP-2        
Claspin        
Clusterin DCLU00 DY5874 DYC2937  
Cytochrome c DCTC0   DYC897  
TRAIL R1/DR4        
TRAIL R2/DR5        
FADD        
Fas/TNFSF6 DFS00 DY326    
HIF-1alpha     DYC1935  
HO-1/HMOX1/HSP32     DYC3776  
HO-2/HMOX2        
HSP27     DYC1580 DYC2314
HSP60     DYC1800  
HSP70     DYC1663  
HTRA2/Omi        
Livin        
PON2     DYC4344  
p21/CIP1/CDNK1A     DYC1047  
p27/Kip1     DYC2256  
phospho-p53 (S15)     DYC1043 DYC1839
phospho-p53 (S46)     DYC1043 DYC1489
phospho-p53 (S392)     DYC1043 DYC2996
phospho-Rad17 (S635)        
SMAC/Diablo     DYC789  
Survivin DSV00 DYC647    
TNF RI/TNFRSF1A DRT100 DY225    
XIAP     DYC822  

 

Western blotting antibodies for analytes related to the Human Apoptosis Array Kit

Analyte Phospho-Specific Antibodies Affinity Purified Polyclonal Antibodies (Total) Monoclonal Antibodies (Total) Labeled Antibodies (Total)
Bad   AF819 MAB6405  
Bax   AF820 MAB846, MAB883, 2282-MC-100  
Bcl-2   AF810 MAB8272  
Bcl-x   AF800    
Cleaved Caspase-3     MAB835  
Catalase   AF3398    
cIAP-1   AF8181 MAB818  
cIAP-2   AF8171 MAB817, MAB3400, MAB3310 BAF8171
Claspin   AF3310   BAF3310
Clusterin   AF2937 MAB2937 BAF2937
Cytochrome c     MAB897  
Trail R1/DR4   AF347   BAF347
Trail R2/DR5   AF631   BAF631
FADD MAB7047 (S194) AF2938    
Fas/TNFSF6   AF326 MAB142 BAF326
HIF-1alpha   AF1935 MAB1536  
HO-1/HMOX1/ HSP32   AF3776 MAB3776  
HO-2/HMOX2   AF3170 MAB3170  
HSP27 AF2314 (S78/S82) AF1580, AF15801    
HSP60   AF1800 MAB1800  
HSP70   AF1663 MAB1663  
HTRA2/Omi   AF1458 MAB1458  
Livin   AF1161    
PON2   AF4344 MAB4344  
p21/CIP1/CDNK1A   AF1047 MAB1047 BAF1047
p27/Kip1 AF1555 (T157), AF3994 (T198) AF2256 MAB2256  
phospho-p53 (S15) AF1043 (S15), MAB1839 (S15) AF1355 MAB1355 BAF1355, HAF1355
phospho-p53 (S46) AF1489 (S46), MAB1489 (S46) AF1355 MAB1355 BAF1355, HAF1355
phospho-p53 (S392) AF2996 (S392) AF1355 MAB1355 BAF1355, HAF1355
phospho-Rad17 (S635) AF1374 (S635) AF1926    
SMAC/Diablo   AF789, AF7891   BAF789
TNF RI/TNFRSF1A   AF225 MAB225, MAB625 BAF225
XIAP   AF8221 MAB822 BAF8221

 

Data Examples
K562, THP-1 and SK-Mel-28
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Figure 1A: K562 human chronic myelogenous leukemia cells.

Figure 1B: THP-1 human acute monocytic leukemia cells.

Figure 1C: SK-Mel-28 human malignant melanoma cells.
Jurkat human acute T cell leukemia cells
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Figure 2A: Jurkat human acute T cell leukemia cells were either untreated or treated with 25 µM etoposide for 6 hours. Etoposide is a topoisomerase II inhibitor that causes caspase-3 cleavage as apoptosis is induced.

Product Datasheets

Product Datasheet
COA
SDS

Preparation and Storage

Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Apoptosis Array Kit

R&D Systems' Human Apoptosis Array Kit (Catalog # ARY009) is a rapid, sensitive, and economical tool to simultaneously detect the relative levels of expression of 35 apoptosis-related proteins in a single sample. No specialized equipment is necessary.

Alternate Names
Apoptosis Array Kit

Citations for Proteome Profiler Human Apoptosis Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

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  1. HPV-Mediated Resistance to TNF and TRAIL Is Characterized by Global Alterations in Apoptosis Regulatory Factors, Dysregulation of Death Receptors, and Induction of ROS/RNS
    Authors: TK Cabeça, A de Mello A, R Andrette, V de Souza L, MG Morale, F Aguayo, L Termini, LL Villa, AP Lepique, E Boccardo
    Int J Mol Sci, 2019;20(1):.  2019
  2. Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis
    Authors: L Peix, IC Evans, DR Pearce, JK Simpson, TM Maher, RJ McAnulty
    Sci Rep, 2018;8(1):1906.  2018
  3. Curcumin Analog DK1 Induces Apoptosis in Human Osteosarcoma Cells In Vitro through Mitochondria-Dependent Signaling Pathway
    Authors: MNM Aziz, Y Hussin, NF Che Rahim, N Nordin, NE Mohamad, SK Yeap, CY Yong, MJ Masarudin, YK Cheah, N Abu, MN Akhtar, NB Alitheen
    Molecules, 2018;23(1):.  2018
  4. Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma
    Authors: D Xu, SQ Liang, H Yang, U Lüthi, C Riether, S Berezowska, TM Marti, SRR Hall, R Bruggmann, GJ Kocher, RA Schmid, RW Peng
    Br. J. Cancer, 2018;0(0):.  2018
  5. Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs
    Authors: B Haas, V Klinger, C Keksel, V Bonigut, D Kiefer, J Caspers, J Walther, M Wos-Magang, S Weickhardt, G Röhn, M Timmer, R Frötschl, N Eckstein
    Cancer Cell Int., 2018;18(0):69.  2018
  6. KRas4B-PDE6? complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer
    Authors: D Casique-Ag, P Briseño-Dí, P García-Gut, CHG la Rosa, RS Quintero-B, A Rojo-Domín, I Vergara, LA Medina, J Correa-Bas, M Bello, R Hernández-, M Del RocioT, M Vargas
    BMC Cancer, 2018;18(1):1299.  2018
  7. 6- and 8-Prenylnaringenin, Novel Natural Histone Deacetylase Inhibitors Found in Hops, Exert Antitumor Activity on Melanoma Cells
    Authors: S Venturelli, H Niessner, T Sinnberg, A Berger, M Burkard, C Urmann, K Donaubauer, A Böcker, C Leischner, H Riepl, J Frank, UM Lauer, C Garbe, C Busch
    Cell. Physiol. Biochem., 2018;51(2):543-556.  2018
  8. Targeting PDK4 inhibits breast cancer metabolism
    Authors: MR Guda, S Asuthkar, CM Labak, AJ Tsung, I Alexandrov, MJ Mackenzie, DV Prasad, KK Velpula
    Am J Cancer Res, 2018;8(9):1725-1738.  2018
  9. Induction of apoptosis by pinostrobin in human cervical cancer cells: Possible mechanism of action
    Authors: A Jaudan, S Sharma, SNA Malek, A Dixit
    PLoS ONE, 2018;13(2):e0191523.  2018
  10. DK1 Induces Apoptosis via Mitochondria-Dependent Signaling Pathway in Human Colon Carcinoma Cell Lines In Vitro
    Authors: Y Hussin, MNM Aziz, NF Che Rahim, SK Yeap, NE Mohamad, MJ Masarudin, N Nordin, NMA Abd Rahman, CY Yong, MN Akhtar, SNH Zamrus, NB Alitheen
    Int J Mol Sci, 2018;19(4):.  2018
  11. Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling
    Authors: R Johnson, S Shabalala, J Louw, AP Kappo, CJF Muller
    Molecules, 2017;22(10):.  2017
  12. MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis
    Authors: CS Mak, MM Yung, LM Hui, LL Leung, R Liang, K Chen, SS Liu, Y Qin, TH Leung, KF Lee, KK Chan, HY Ngan, DW Chan
    Mol. Cancer, 2017;16(1):11.  2017
  13. Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
    Authors: M Mustapic, E Eitan, JK Werner, ST Berkowitz, MP Lazaropoul, J Tran, EJ Goetzl, D Kapogianni
    Front Neurosci, 2017;11(0):278.  2017
  14. Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide
    Authors: SS Kim, JB Harford, M Moghe, A Rait, KF Pirollo, EH Chang
    Nucleic Acids Res., 2017;0(0):.  2017
  15. The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells
    Authors: IC Etti, R Abdullah, A Kadir, NM Hashim, SK Yeap, MU Imam, F Ramli, I Malami, KL Lam, U Etti, P Waziri, M Rahman
    PLoS ONE, 2017;12(8):e0182357.  2017
  16. Discovery of a novel small molecule inhibitor that targets PP2A-?-Catenin signaling and restricts tumor growth and metastasis
    Authors: S Maheshwari, AS Rao, A Singh, LR Singh, GR Palnati, RK Arya, SH Cheruvu, S Shahi, T Sharma, S Meena, AK Singh, R Kant, M Riyazuddin, HK Bora, MI Siddiqi, JR Gayen, KV Sashidhara, D Datta
    Mol. Cancer Ther., 2017;0(0):.  2017
  17. Dual Inhibition of HDAC and tyrosine kinase signaling pathways with CUDC-907 inhibits thyroid cancer growth and metastases
    Authors: S Kotian, L Zhang, M Boufraqech, K Gaskins, SK Gara, MM Quezado, N Nilubol, E Kebebew
    Clin. Cancer Res., 2017;0(0):.  2017
  18. Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia
    Authors: MM Salman, P Kitchen, MN Woodroofe, RM Bill, AC Conner, PR Heath, MT Conner
    Front Cell Neurosci, 2017;11(0):386.  2017
  19. Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival
    Authors: RJ Chen, CT Shun, ML Yen, CH Chou, MC Lin
    Oncotarget, 2017;8(37):62081-62098.  2017
  20. Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest
    Authors: K Oura, T Tadokoro, S Fujihara, A Morishita, T Chiyo, E Samukawa, Y Yamana, K Fujita, T Sakamoto, T Nomura, H Yoneyama, H Kobara, H Mori, H Iwama, K Okano, Y Suzuki, T Masaki
    Oncol. Rep., 2017;38(5):2825-2835.  2017
  21. Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells
    Authors: IC Etti, A Rasedee, NM Hashim, AB Abdul, A Kadir, SK Yeap, P Waziri, I Malami, KL Lim, CJ Etti
    Drug Des Devel Ther, 2017;11(0):865-879.  2017
  22. Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell
    Authors: S Chen, J Tao, F Zhong, Y Jiao, J Xu, Q Shen, H Wang, S Fan, Y Zhang
    PLoS ONE, 2017;12(5):e0176501.  2017
  23. WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response
    Authors: S Janczar, J Nautiyal, Y Xiao, E Curry, M Sun, E Zanini, AJ Paige, H Gabra
    Cell Death Dis, 2017;8(7):e2955.  2017
  24. SurR9C84A Protects and Recovers Human Cardiomyocytes from Hypoxia Induced Apoptosis
    Authors: Rupinder Kaur Kanwar
    Exp. Cell Res., 2016;0(0):.  2016
  25. Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells.
    Authors: Skolekova S, Matuskova M, Bohac M, Toro L, Demkova L, Gursky J, Kucerova L
    Cell Commun Signal, 2016;14(1):4.  2016
  26. MCPIP1 Exogenous Overexpression Inhibits Pathways Regulating MYCN Oncoprotein Stability in Neuroblastoma
    Authors: El?bieta Boratyn
    J. Cell. Biochem, 2016;0(0):.  2016
  27. Synergistic effects of combined treatment with histone deacetylase inhibitor suberoylanilide hydroxamic acid and TRAIL on human breast cancer cells
    Authors: Weiqiang Zhou
    Sci Rep, 2016;6(0):28004.  2016
  28. Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma
    PLoS ONE, 2016;11(9):e0159749.  2016
  29. Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas
    Sci Rep, 2016;6(0):38792.  2016
  30. Differential effects of Helenalin, an anti-inflammatory sesquiterpene lactone, on the proteome, metabolome and the oxidative stress response in several immune cell types
    Authors: Paula Zwicker
    Toxicol In Vitro, 2016;40(0):45-54.  2016
  31. Suppression of mir-200 family expression by oncogenic KRAS activation promotes cell survival and epithelial-mesenchymal transition in KRAS-driven cancer
    Mol Cell Biol, 2016;0(0):.  2016
  32. Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment
    PLoS ONE, 2016;11(7):e0159013.  2016
  33. Large-scale pharmacological profiling of 3D tumor models of cancer cells
    Cell Death Dis, 2016;7(12):e2492.  2016
  34. GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway.
    Authors: Mahata B, Biswas S, Rayman P, Chahlavi A, Ko J, Bhattacharjee A, Li Y, Li Y, Das T, Sa G, Raychaudhuri B, Vogelbaum M, Tannenbaum C, Finke J, Biswas K
    PLoS ONE, 2015;10(7):e0134425.  2015
  35. Decidualization and syndecan-1 knock down sensitize endometrial stromal cells to apoptosis induced by embryonic stimuli.
    Authors: Boeddeker S, Baston-Buest D, Fehm T, Kruessel J, Hess A
    PLoS ONE, 2015;10(4):e0121103.  2015
  36. Inhibition of Survivin with YM155 Induces Durable Tumor Response in Anaplastic Thyroid Cancer.
    Authors: Mehta A, Zhang L, Boufraqech M, Liu-Chittenden Y, Zhang Y, Patel D, Davis S, Rosenberg A, Ylaya K, Aufforth R, Li Z, Shen M, Kebebew E
    Clin Cancer Res, 2015;21(18):4123-32.  2015
  37. AMP-18 Targets p21 to Maintain Epithelial Homeostasis.
    Authors: Chen P, Li Y, Toback F
    PLoS ONE, 2015;10(4):e0125490.  2015
  38. Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer.
    Authors: Urbinati G, Ali H, Rousseau Q, Chapuis H, Desmaele D, Couvreur P, Massaad-Massade L
    PLoS ONE, 2015;10(5):e0125277.  2015
  39. EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer.
    Authors: Subramanian N, Kanwar J, Kanwar R, Sreemanthula J, Biswas J, Khetan V, Krishnakumar S
    PLoS ONE, 2015;10(7):e0132407.  2015
  40. Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma.
    Authors: Tanase, Cristian, Albulescu, Radu, Codrici, Elena, Calenic, Bogdan, Popescu, Ionela D, Mihai, Simona, Necula, Laura, Cruceru, Maria Li, Hinescu, Mihail E
    Onco Targets Ther, 2015;8(0):81-90.  2015
  41. B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection.
    Authors: Nothelfer K, Arena E, Pinaud L, Neunlist M, Mozeleski B, Belotserkovsky I, Parsot C, Dinadayala P, Burger-Kentischer A, Raqib R, Sansonetti P, Phalipon A
    J Exp Med, 2014;211(6):1215-29.  2014
  42. Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets.
    Authors: Tang, Wai Ho, Stitham, Jeremiah, Jin, Yu, Liu, Renjing, Lee, Seung He, Du, Jing, Atteya, Gourg, Gleim, Scott, Spollett, Geralyn, Martin, Kathleen, Hwa, John
    Circulation, 2014;129(15):1598-609.  2014
  43. Vertical blockade of the IGFR- PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: the role of survivin.
    Authors: Ou, Da-Liang, Lee, Bin-Shyu, Lin, Liang-In, Liou, Jun-Yang, Liao, Sheng-Ch, Hsu, Chiun, Cheng, Ann-Lii
    Mol Cancer, 2014;13(0):2.  2014
  44. Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.
    Authors: Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z, Chen X, Qin N, Zhang X
    PLoS ONE, 2014;9(1):e85296.  2014
  45. ABCB5 is a limbal stem cell gene required for corneal development and repair.
    Authors: Ksander B, Kolovou P, Wilson B, Saab K, Guo Q, Ma J, McGuire S, Gregory M, Vincent W, Perez V, Cruz-Guilloty F, Kao W, Call M, Tucker B, Zhan Q, Murphy G, Lathrop K, Alt C, Mortensen L, Lin C, Zieske J, Frank M, Frank N
    Nature, 2014;511(7509):353-7.  2014
  46. High dose ionizing radiation regulates micro RNA and gene expression changes in human peripheral blood mononuclear cells.
    Authors: Beer L, Seemann R, Ristl R, Ellinger A, Kasiri M, Mitterbauer A, Zimmermann M, Gabriel C, Gyongyosi M, Klepetko W, Mildner M, Ankersmit H
    BMC Genomics, 2014;15(0):814.  2014
  47. How liposomal Cisplatin overcomes chemoresistance in ovarian tumour cells.
    Anticancer Res, 2014;34(1):525-30.  2014
  48. MicroRNA-155 as an inducer of apoptosis and cell differentiation in Acute Myeloid Leukaemia.
    Authors: Palma, Catalina, Al Sheikha, Dima, Lim, Teck Kha, Bryant, Adam, Vu, Thi Than, Jayaswal, Vivek, Ma, David D
    Mol Cancer, 2014;13(0):79.  2014
  49. Targeting ovarian cancer and chemoresistance through selective inhibition of sphingosine kinase-2 with ABC294640.
    Authors: White, Martin D, Chan, Lucas, Antoon, James W, Beckman, Barbara
    Anticancer Res, 2013;33(9):3573-9.  2013
  50. The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer.
    Authors: Hage C, Rausch V, Giese N, Giese T, Schonsiegel F, Labsch S, Nwaeburu C, Mattern J, Gladkich J, Herr I
    Cell Death Dis, 2013;4(0):e627.  2013
  51. Cold atmospheric plasma (CAP) changes gene expression of key molecules of the wound healing machinery and improves wound healing in vitro and in vivo.
    Authors: Arndt S, Unger P, Wacker E, Shimizu T, Heinlin J, Li Y, Thomas H, Morfill G, Zimmermann J, Bosserhoff A, Karrer S
    PLoS ONE, 2013;8(11):e79325.  2013
  52. Cidofovir: a novel antitumor agent for glioblastoma.
    Authors: Hadaczek P, Ozawa T, Soroceanu L, Yoshida Y, Matlaf L, Singer E, Fiallos E, James C, Cobbs C
    Clin Cancer Res, 2013;19(23):6473-83.  2013
  53. NFATc2 is a potential therapeutic target in human melanoma.
    J. Invest. Dermatol., 2012;132(11):2652-60.  2012
  54. Cacospongionolide and scalaradial, two marine sesterterpenoids as potent apoptosis-inducing factors in human carcinoma cell lines.
    Authors: De Stefano D, Tommonaro G, Malik SA, Iodice C, De Rosa S, Maiuri MC, Carnuccio R
    PLoS ONE, 2012;7(4):e33031.  2012
  55. Antiapoptotic signaling via MCL1 confers resistance to caspase-3-mediated apoptotic cell death in the pregnant human uterine myocyte.
    Authors: Stephenson-Famy A, Marks J, Suresh A
    Mol. Endocrinol., 2012;26(2):320-30.  2012
  56. TWEAK affects keratinocyte G2/M growth arrest and induces apoptosis through the translocation of the AIF protein to the nucleus.
    Authors: Sabour Alaoui S, Dessirier V, de Araujo E, Alexaki VI, Pelekanou V, Lkhider M, Stathopoulos EN, Castanas E, Bagot M, Bensussan A, Tsapis A
    PLoS ONE, 2012;7(3):e33609.  2012
  57. Locally different endothelial nitric oxide synthase protein levels in ascending aortic aneurysms of bicuspid and tricuspid aortic valve.
    Authors: Mohamed SA, Radtke A, Saraei R
    Cardiol Res Pract, 2012;2012(0):165957.  2012
  58. Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma.
    Authors: Schulze D, Plohmann P, Hobel S, Aigner A
    Mol. Cancer, 2011;10(0):144.  2011
  59. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.
    Authors: Li J, Cho YY, Langfald A
    Cancer Prev Res (Phila), 2011;4(8):1190-7.  2011
  60. LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma.
    Authors: Dormoy V, Beraud C, Lindner V, Thomas L, Coquard C, Barthelmebs M, Jacqmin D, Lang H, Massfelder T
    Oncogene, 2011;30(15):1753-63.  2011
  61. Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis.
    Authors: Ray RB, Raychoudhuri A, Steele R
    Cancer Res., 2010;70(5):1925-31.  2010
  62. Inhibition of caspase-3 differentially affects vascular smooth muscle cell apoptosis in the concave versus convex aortic sites in ascending aneurysms with a bicuspid aortic valve.
    Authors: Mohamed SA, Misfeld M, Hanke T, Charitos EI, Bullerdiek J, Belge G, Kuehnel W, Sievers HH
    Ann. Anat., 2010;192(3):145-50.  2010
  63. CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1.
    Authors: Datta D, Banerjee P, Gasser M
    J. Biol. Chem., 2010;285(47):36842-8.  2010
  64. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
    Authors: Cailleteau C, Liagre B, Beneytout JL
    J. Cell. Biochem., 2009;107(4):785-96.  2009

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Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 02/07/2019
Proteome Profiler Human Apoptosis Array Kit ARY009
Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 12/12/2018

COLO 205 cancer cells were drug treated and vehicle and apoptosis proteins analyzed. 3 minute exposure time.

Proteome Profiler Human Apoptosis Array Kit ARY009
Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 12/11/2018
Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 09/13/2018

Very nice kit with easy to follow protocol. Good tool for discovery biology. We used to test small molecule induction of apoptosis in breast cancer cells. I would recommend this kit to anyone looking to profile multiple apoptosis pathways at once. Spot placement was very consistent which made analysis easy.

Proteome Profiler Human Apoptosis Array Kit ARY009
Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 01/12/2018
Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 10/31/2017
Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 10/31/2017
Proteome Profiler Human Apoptosis Array Kit ARY009
Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 09/07/2017
Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 01/03/2017

This array is an excellent tool for screening potential apoptosis related targets. However, it would be nice that if more common targets can be included, e.g. tBid, cleaved PARP and cleaved Caspase9.

Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 10/26/2015
Sample Tested: Tumor cell lyastes

These are arrays are used to determine the changes in the expression of proteins of different apoptotic pathways. The signal is quantified to detect the changes. Protocol instructions are good and easy to follow.
Specificity: Reasonably specific
Sensitivity: Reasonably sensitive
Buffer: BSA
Dilution: 1:1000

Proteome Profiler Human Apoptosis Array Kit ARY009