Proteome Profiler Human Apoptosis Array Kit

Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies
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Determination of Relative Levels of Human Apoptosis-related Proteins Using Proteome Profiler Human Apoptosis Array Kit.
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Citations (135)
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Proteome Profiler Human Apoptosis Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of human apoptosis-related proteins. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects 35 human apoptosis-related proteins simultaneously
  • Requires no specialized equipment


Principle of the Assay

The Proteome Profiler Human Apoptosis Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Captured proteins are detected with biotinylated detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of the bound analyte.

Why Use an Antibody Array to Detect Apoptosis-Related Proteins?

Determining the expression of multiple proteins in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple proteins in a single sample can be cost-effective and also save time and sample.


Kit Contents
  • 4 Array Membranes
  • 4-Well Multi-dish
  • Array Buffers
  • Lysis Buffer
  • Wash Buffer
  • Antibody Detection Cocktail
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed Protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.

Simultaneously detect the relative levels of these apoptosis-related proteins in a single sample.
Bcl-2 FADD p27/Kip1
Bcl-x Fas/TNFSF6 Phospho-p53 (S15)
Pro-Caspase-3 HIF-1 alpha Phospho-p53 (S46)
Cleaved Caspase-3 HO-1/HMOX1/HSP32 Phospho-p53 (S392)
Catalase HO-2/HMOX2 Phospho-Rad17 (S635)
cIAP-1 HSP27 Pro-Caspase-3
cIAP-2 HSP60 SMAC/Diablo
Claspin HSP70 Survivin
Cytochrome c Livin XIAP


Assays for analytes represented in the Human Apoptosis Array Kit

Analyte Quantikine® ELISA Kits DuoSet® ELISA Development Systems DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA Development Systems (Phospho or Active)
Bad     DYC819  
Bax     DYC820  
Bcl-2     DYC827B  
Cleaved Caspase-3 KM300   DYC835  
Clusterin DCLU00 DY5874 DYC2937  
Cytochrome c DCTC0   DYC897  
TRAIL R1/DR4        
TRAIL R2/DR5        
Fas/TNFSF6 DFS00 DY326    
HIF-1alpha     DYC1935  
HO-1/HMOX1/HSP32     DYC3776  
HSP27     DYC1580 DYC2314
HSP60     DYC1800  
HSP70     DYC1663  
PON2     DYC4344  
p21/CIP1/CDNK1A     DYC1047  
p27/Kip1     DYC2256  
phospho-p53 (S15)     DYC1043 DYC1839
phospho-p53 (S46)     DYC1043 DYC1489
phospho-p53 (S392)     DYC1043 DYC2996
phospho-Rad17 (S635)        
SMAC/Diablo     DYC789  
Survivin DSV00 DYC647    
XIAP     DYC822  


Western blotting antibodies for analytes related to the Human Apoptosis Array Kit

Analyte Phospho-Specific Antibodies Affinity Purified Polyclonal Antibodies (Total) Monoclonal Antibodies (Total) Labeled Antibodies (Total)
Bad   AF819 MAB6405  
Bax   AF820 MAB846, MAB883, 2282-MC-100  
Bcl-2   AF810 MAB8272  
Bcl-x   AF800    
Cleaved Caspase-3     MAB835  
Catalase   AF3398    
cIAP-1   AF8181 MAB818  
cIAP-2   AF8171 MAB817, MAB3400, MAB3310 BAF8171
Claspin   AF3310   BAF3310
Clusterin   AF2937 MAB2937 BAF2937
Cytochrome c     MAB897  
Trail R1/DR4   AF347   BAF347
Trail R2/DR5   AF631   BAF631
FADD MAB7047 (S194) AF2938    
Fas/TNFSF6   AF326 MAB142 BAF326
HIF-1alpha   AF1935 MAB1536  
HO-1/HMOX1/ HSP32   AF3776 MAB3776  
HO-2/HMOX2   AF3170 MAB3170  
HSP27 AF2314 (S78/S82) AF1580, AF15801    
HSP60   AF1800 MAB1800  
HSP70   AF1663 MAB1663  
HTRA2/Omi   AF1458 MAB1458  
Livin   AF1161    
PON2   AF4344 MAB4344  
p21/CIP1/CDNK1A   AF1047 MAB1047 BAF1047
p27/Kip1 AF1555 (T157), AF3994 (T198) AF2256 MAB2256  
phospho-p53 (S15) AF1043 (S15), MAB1839 (S15) AF1355 MAB1355 BAF1355, HAF1355
phospho-p53 (S46) AF1489 (S46), MAB1489 (S46) AF1355 MAB1355 BAF1355, HAF1355
phospho-p53 (S392) AF2996 (S392) AF1355 MAB1355 BAF1355, HAF1355
phospho-Rad17 (S635) AF1374 (S635) AF1926    
SMAC/Diablo   AF789, AF7891   BAF789
XIAP   AF8221 MAB822 BAF8221


Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Product Datasheets

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Scientific Data

Determination of Relative Levels of Human Apoptosis-related Proteins Using Proteome Profiler Human Apoptosis Array Kit. Figure 1A: K562 human chronic myelogenous leukemia cells.
Figure 1B: THP-1 human acute monocytic leukemia cells.
Figure 1C: SK-Mel-28 human malignant melanoma cells.

Determination of Relative Levels of Human Apoptosis-related Proteins Using Proteome Profiler Human Apoptosis Array Kit. Jurkat human acute T cell leukemia cells were either untreated or treated with 25 µM etoposide for 6 hours. Etoposide is a topoisomerase II inhibitor that causes caspase-3 cleavage as apoptosis is induced.

Citations for Proteome Profiler Human Apoptosis Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

135 Citations: Showing 1 - 10
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  1. Apoptotic effect and cell arrest of deoxyshikonin in human osteosarcoma cells through the p38 pathway
    Authors: Hsieh, MC;Hsieh, YH;Chou, CH;Yang, JS;Lu, PW;Huang, TY;Yang, SF;Lu, KH;
    Journal of cellular and molecular medicine  2023-05-08
  2. Induction of Apoptosis and Decrease of Autophagy in Colon Cancer Cells by an Extract of Lyophilized Mango Pulp
    Authors: GA Lozano-Cas, SS Arango-Var, ME Maldonado-
    International Journal of Environmental Research and Public Health, 2023-02-25;20(5):.  2023-02-25
  3. Semilicoisoflavone B Induces Apoptosis of Oral Cancer Cells by Inducing ROS Production and Downregulating MAPK and Ras/Raf/MEK Signaling
    Authors: MJ Hsieh, HY Ho, YS Lo, CC Lin, YC Chuang, MM Abomughaid, MC Hsieh, MK Chen
    International Journal of Molecular Sciences, 2023-02-24;24(5):.  2023-02-24
  4. CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors
    Authors: J Wang, A Calizo, L Zhang, JC Pino, Y Lyu, K Pollard, X Zhang, AT Larsson, E Conniff, N Llosa, DK Wood, DA Largaespad, SE Moody, SJ Gosline, AC Hirbe, CA Pratilas
    bioRxiv : the preprint server for biology, 2023-02-03;0(0):.  2023-02-03
  5. ADS024, a Bacillus velezensis strain, protects human colonic epithelial cells against C. difficile toxin-mediated apoptosis
    Authors: Y Xie, A Chupina Es, B Nelson, H Feng, C Pothoulaki, L Chesnel, HW Koon
    Frontiers in Microbiology, 2023-01-10;13(0):1072534.  2023-01-10
  6. Mycoplasma hominis Causes DNA Damage and Cell Death in Primary Human Keratinocytes
    Authors: AT Amorim, VS Lino, LM Marques, DJ Martins, ACR Braga Juni, GB Campos, CNT Oliveira, E Boccardo, J Timenetsky
    Microorganisms, 2022-10-01;10(10):.  2022-10-01
  7. Phytochemical analysis of Artemisia kopetdaghensis: Sesquiterpene lactones with proapoptotic activity against prostate cancer cells
    Authors: M Fattahian, M Ghanadian, B Zolfaghari, M Aghaei, F Zulfiqar, IA Khan, Z Ali
    Phytochemistry, 2022-08-28;203(0):113411.  2022-08-28
  8. Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1alpha/BNIP3-LC3B/mitophagy signaling
    Authors: K Wang, YS Chen, HW Chien, HL Chiou, SF Yang, YH Hsieh
    Cell & bioscience, 2022-08-19;12(1):133.  2022-08-19
  9. Analysis of regulating activities of 5'-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo
    Authors: X Wang, X Luo, X Gan, C Chen, Z Yang, J Wen, W Fang, H Huang, C Gao, X Zhou, X Feng, Y Liu
    Frontiers in Pharmacology, 2022-08-10;13(0):920554.  2022-08-10
  10. Depleting TMED3 alleviates the development of endometrial carcinoma
    Authors: J Zhang, Y Qi
    Cancer Cell International, 2022-07-19;22(1):231.  2022-07-19
  11. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways
    Authors: HY Ho, PJ Chen, YC Chuang, YS Lo, CC Lin, MJ Hsieh, MK Chen
    International Journal of Molecular Sciences, 2022-05-29;23(11):.  2022-05-29
  12. The effect of apigenin and chemotherapy combination treatments on apoptosis-related genes and proteins in acute leukaemia cell lines
    Authors: AA Mahbub, CL Le Maitre, NA Cross, N Jordan-Mah
    Scientific Reports, 2022-05-25;12(1):8858.  2022-05-25
  13. Design, synthesis, and evaluation of a novel series of mono-indolylbenzoquinones derivatives for the potential treatment of breast cancer
    Authors: J Jia, H Yin, C Chen, M Hu, Q Zhong, S Zheng, W Zhang, H Li, L Xu, G Wang, L He
    European Journal of Medicinal Chemistry, 2022-04-16;237(0):114375.  2022-04-16
  14. Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis
    Authors: DC Kirman, B Renganatha, WK Chui, MW Chen, NA Kaya, R Ge
    Cell Death & Disease, 2022-02-23;13(2):172.  2022-02-23
  15. Curcumin analog HO-3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells
    Authors: CW Chen, MJ Hsieh, PC Ju, YH Hsieh, CW Su, YL Chen, SF Yang, CW Lin
    Journal of Cellular and Molecular Medicine, 2022-02-21;0(0):.  2022-02-21
  16. Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma
    Authors: M Koizumi, T Watanabe, J Masumoto, K Sunago, Y Imamura, K Kanemitsu, T Kumagi, Y Hiasa
    Scientific Reports, 2021-11-16;11(1):22351.  2021-11-16
  17. RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
    Authors: J George, Y Li, IP Kadamberi, D Parashar, SW Tsaih, P Gupta, A Geethadevi, C Chen, C Ghosh, Y Sun, S Mittal, R Ramchandra, H Rui, G Lopez-Bere, C Rodriguez-, G Leone, JS Rader, AK Sood, M Dey, S Pradeep, P Chaluvally
    Cell Reports, 2021-11-02;37(5):109934.  2021-11-02
  18. Magnolol Triggers Caspase-Mediated Apoptotic Cell Death in Human Oral Cancer Cells through JNK1/2 and p38 Pathways
    Authors: YT Chen, CW Lin, CW Su, WE Yang, CY Chuang, SC Su, MJ Hsieh, SF Yang
    Biomedicines, 2021-09-22;9(10):.  2021-09-22
  19. Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer
    Authors: SC Wang, YC Chang, MY Wu, CY Yu, SL Chen, WW Sung
    Cancers, 2021-08-04;13(16):.  2021-08-04
  20. Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity
    Authors: P Doan, P Nguyen, A Murugesan, NR Candeias, O Yli-Harja, M Kandhavelu
    Cells, 2021-08-03;10(8):.  2021-08-03
  21. Complement Factor C5a Inhibits Apoptosis of Neutrophils-A Mechanism in Polytrauma?
    Authors: C Ehrnthalle, S Braumüller, S Kellermann, F Gebhard, M Perl, M Huber-Lang
    Journal of Clinical Medicine, 2021-07-17;10(14):.  2021-07-17
  22. Overexpression of PSMC2 promotes the tumorigenesis and development of human breast cancer via regulating plasminogen activator urokinase (PLAU)
    Authors: Y Wang, M Zhu, J Li, Y Xiong, J Wang, H Jing, Y Gu
    Cell Death & Disease, 2021-07-09;12(7):690.  2021-07-09
  23. ALPK2 acts as tumor promotor in development of bladder cancer through targeting DEPDC1A
    Authors: Y Wang, J Wu, W Luo, H Zhang, G Shi, Y Shen, Y Zhu, C Ma, B Dai, D Ye, Y Zhu
    Cell Death & Disease, 2021-07-01;12(7):661.  2021-07-01
  24. Inverse and reciprocal regulation of p53/p21 and Bmi-1 modulates vasculogenic differentiation of dental pulp stem cells
    Authors: Z Zhang, M Oh, JI Sasaki, JE Nör
    Cell Death & Disease, 2021-06-24;12(7):644.  2021-06-24
  25. Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53
    Authors: P Malkomes, I Lunger, E Oppermann, K Abou-El-Ar, T Oellerich, S Günther, C Canbulat, S Bothur, F Schnütgen, W Yu, S Wingert, N Haetscher, C Catapano, MS Dietz, M Heilemann, HM Kvasnicka, K Holzer, H Serve, WO Bechstein, MA Rieger
    Oncogene, 2021-06-08;0(0):.  2021-06-08
  26. Long-Term Exposure to Nanosized TiO2 Triggers Stress Responses and Cell Death Pathways in Pulmonary Epithelial Cells
    Authors: M Alswady-Ho, JS Erdem, S Phuyal, O Knittelfel, A Sharma, DM Fonseca, Ø Skare, G Slupphaug, S Zienolddin
    International Journal of Molecular Sciences, 2021-05-19;22(10):.  2021-05-19
  27. Knock-down of LRP/LR influences signalling pathways in late-stage colorectal carcinoma cells
    Authors: L Vania, G Morris, E Ferreira, SFT Weiss
    BMC Cancer, 2021-04-09;21(1):392.  2021-04-09
  28. The Antitumor Effects of Plasma-Activated Saline on Muscle-Invasive Bladder Cancer Cells In Vitro and In Vivo Demonstrate Its Feasibility as a Potential Therapeutic Approach
    Authors: H Zhang, J Zhang, B Guo, H Chen, D Xu, MG Kong
    Cancers, 2021-03-02;13(5):.  2021-03-02
  29. TGF-&beta1 signaling inhibit the in vitro apoptotic, infection and stimulatory cell response induced by influenza H1N1 virus infection on A549 cells
    Authors: GB Rivera-Bah, AH Márquez-Ba, DV López-Guer, FR Esquivel-G, JL Montiel-He
    Virus research, 2021-02-10;0(0):198337.  2021-02-10
  30. Luteolin inhibits proliferation, triggers apoptosis and modulates Akt/mTOR and MAP kinase pathways in HeLa cells
    Authors: R Raina, S Pramodh, N Rais, S Haque, J Shafarin, K Bajbouj, M Hamad, A Hussain
    Oncology Letters, 2021-01-07;21(3):192.  2021-01-07
  31. Carbon ion triggered immunogenic necroptosis of nasopharyngeal carcinoma cells involving necroptotic inhibitor BCL-x
    Authors: C Bao, Y Sun, B Dwarakanat, Y Dong, Y Huang, X Wu, C Guha, L Kong, JJ Lu
    Journal of Cancer, 2021-01-01;12(5):1520-1530.  2021-01-01
  32. Activation of the miR-371/372/373 miRNA Cluster Enhances Oncogenicity and Drug Resistance in Oral Carcinoma Cells
    Authors: SC Lin, HL Wu, LY Yeh, CC Yang, SY Kao, KW Chang
    International Journal of Molecular Sciences, 2020-12-11;21(24):.  2020-12-11
  33. RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer
    Authors: H Khawaja, A Campbell, JZ Roberts, A Javadi, P O'Reilly, D McArt, WL Allen, J Majkut, M Rehm, A Bardelli, F Di Nicolan, CJ Scott, R Kennedy, N Vitale, T Harrison, OJ Sansom, DB Longley, E Evergren, S Van Schaey
    Cell Death Dis, 2020-10-29;11(10):930.  2020-10-29
  34. CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer
    Authors: JC Fleming, J Woo, K Moutasim, CJ Hanley, SJ Frampton, O Wood, M Ward, CH Woelk, CH Ottensmeie, S Hafizi, D Kim, GJ Thomas
    Cancers (Basel), 2020-10-13;12(10):.  2020-10-13
  35. Selinexor Sensitizes TRAIL-R2-Positive TNBC Cells to the Activity of TRAIL-R2xCD3 Bispecific Antibody
    Authors: S Martini, M Figini, A Croce, B Frigerio, M Pennati, AM Gianni, C De Marco, MG Daidone, C Argueta, Y Landesman, N Zaffaroni, A Satta
    Cells, 2020-10-02;9(10):.  2020-10-02
  36. Decreased Thymic Output Contributes to Immune Defects in Septic Patients
    Authors: N Sommer, S Noack, A Hecker, H Hackstein, G Bein, N Weissmann, W Seeger, K Mayer, M Hecker
    J Clin Med, 2020-08-20;9(9):.  2020-08-20
  37. Punicalagin Regulates Apoptosis-Autophagy Switch via Modulation of Annexin A1 in Colorectal Cancer
    Authors: T Ganesan, A Sinniah, Z Chik, MA Alshawsh
    Nutrients, 2020-08-13;12(8):.  2020-08-13
  38. Robustaflavone induces G0/G1 cell cycle arrest and apoptosis in human umbilical vein endothelial cells and exhibits anti-angiogenic effects in vivo
    Authors: WK Sim, JH Park, KY Kim, IS Chung
    Sci Rep, 2020-07-06;10(1):11070.  2020-07-06
  39. Sequesterpene Lactones Isolated from a Brazilian Cerrado Plant (Eremanthus spp.) as Anti-Proliferative Compounds, Characterized by Functional and Proteomic Analysis, are Candidates for New Therapeutics in Glioblastoma
    Authors: C Izumi, HJ Laure, NG Barbosa, C Hassibe Th, G Aguiar Fer, J Paulo Barr, N Peporine L, J César Rosa
    Int J Mol Sci, 2020-07-01;21(13):.  2020-07-01
  40. Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis
    Authors: A Ianevski, E Kulesskiy, K Krpina, G Lou, Y Aman, A Bugai, K Aasumets, Y Akimov, D Bulanova, K Gildemann, AF Arutyunyan, OY Susova, AL Zhuze, P Ji, W Wang, T Holien, M Bugge, E Zusinaite, V Oksenych, H Lysvand, JM Gerhold, M Bjørås, P Johansen, A Waage, CA Heckman, EF Fang, DE Kainov
    Cancers (Basel), 2020-06-25;12(6):.  2020-06-25
  41. Antiproliferative and Apoptotic Effects of Cardamonin against Hepatocellular Carcinoma HepG2 Cells
    Authors: NA Badroon, N Abdul Maji, MA Alshawsh
    Nutrients, 2020-06-12;12(6):.  2020-06-12
  42. TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades
    Authors: SA Scarneo, KW Yang, JR Roques, A Dai, LS Eibschutz, P Hughes, TAJ Haystead
    Oncotarget, 2020-05-26;11(21):1961-1970.  2020-05-26
  43. Two Sides to the Same Coin-Cytotoxicity vs. Potential Metastatic Activity of AgNPs Relative to Triple-Negative Human Breast Cancer MDA-MB-436 Cells
    Authors: M Matysiak-K, M Czajka, B Jod?owska-, K Sawicki, P Wojty?a-Bu, M Kruszewski, L Kapka-Skrz
    Molecules, 2020-05-20;25(10):.  2020-05-20
  44. Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma
    Authors: J Lippmann, K Petri, S Fulda, J Liese
    Transl Oncol, 2020-05-13;13(8):100785.  2020-05-13
  45. The Effect of 4'-hydroxy-3,4,5-trimetoxystilbene, the Metabolite of Resveratrol Analogue DMU-212, on Growth, Cell Cycle and Apoptosis in DLD-1 and LOVO Colon Cancer Cell Lines
    Authors: M Jozkowiak, P Skupin-Mru, A Nowicki, S Borys-Wojc, M Wierzchows, M Kaczmarek, P Ramlau, J Jodynis-Li, H Piotrowska
    Nutrients, 2020-05-07;12(5):.  2020-05-07
  46. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction
    Authors: DJ Trembinski, DI Bink, K Theodorou, J Sommer, A Fischer, A van Bergen, CC Kuo, IG Costa, C Schürmann, MS Leisegang, RP Brandes, T Alekseeva, B Brill, A Wietelmann, CN Johnson, A Spring-Con, M Kaulich, S Werfel, S Engelhardt, MN Hirt, K Yorgan, T Eschenhage, L Kirchhof, P Hofmann, N Jaé, I Wittig, N Hamdani, C Bischof, J Krishnan, RH Houtkooper, S Dimmeler, RA Boon
    Nat Commun, 2020-04-27;11(1):2039.  2020-04-27
  47. Identification of UAP1L1 as tumor promotor in gastric cancer through regulation of CDK6
    Authors: J Qi, S Liu, W Liu, G Cai, G Liao
    Aging (Albany NY), 2020-04-20;12(8):6904-6927.  2020-04-20
  48. Apoptosis characterization in mononuclear blood leukocytes of HIV�patients during dengue acute disease
    Authors: A Torrentes-, JC Sánchez-Ar, T Azamor, LS Barbosa, ED Hottz, M Gandini, FA Bozza, RV da Cunha, LM de Oliveir, PV Damasco, EL de Azeredo
    Sci Rep, 2020-04-14;10(1):6351.  2020-04-14
  49. Dual Targeting of the p38 MAPK-HO-1 Axis and cIAP1/XIAP by Demethoxycurcumin Triggers Caspase-Mediated Apoptotic Cell Death in Oral Squamous Cell Carcinoma Cells
    Authors: MH Chien, WE Yang, YC Yang, CC Ku, WJ Lee, MY Tsai, CW Lin, SF Yang
    Cancers (Basel), 2020-03-16;12(3):.  2020-03-16
  50. Apoptosis Induced by (-)-Epicatechin in Human Breast Cancer Cells is Mediated by Reactive Oxygen Species
    Authors: F Pereyra-Ve, IM Olivares-C, AG Perez-Ruiz, JP Luna-Arias, JR García-Sán
    Molecules, 2020-02-25;25(5):.  2020-02-25
  51. The TUSC2 Tumour Suppressor Inhibits the Malignant Phenotype of Human Thyroid Cancer Cells via SMAC/DIABLO Protein
    Authors: RM Mariniello, FM Orlandella, AE Stefano, PLC Iervolino, G Smaldone, N Luciano, N Cervone, F Munciguerr, S Esposito, P Mirabelli, G Salvatore
    Int J Mol Sci, 2020-01-21;21(3):.  2020-01-21
  52. PLF-1 (Proliferin-1) Modulates Smooth Muscle Cell Proliferation and Development of Experimental Intimal Hyperplasia
    Authors: L Hu, Z Huang, H Ishii, H Wu, S Suzuki, A Inoue, W Kim, H Jiang, X Li, E Zhu, L Piao, G Zhao, Y Lei, K Okumura, GP Shi, T Murohara, M Kuzuya, XW Cheng
    J Am Heart Assoc, 2019-12-16;8(24):e005886.  2019-12-16
  53. Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-phase Arrest on Glioma Cell Lines
    Authors: VAO Silva, MN Rosa, A Tansini, O Martinho, A Tanuri, AF Evangelist, A Cruvinel C, JP Lima, LF Pianowski, RM Reis
    Molecules, 2019-11-22;24(23):.  2019-11-22
  54. Modeling Snyder-Robinson Syndrome in multipotent stromal cells reveals impaired mitochondrial function as a potential cause for deficient osteogenesis
    Authors: AL Ramsay, V Alonso-Gar, C Chaboya, B Radut, B Le, J Florez, C Schumacher, FA Fierro
    Sci Rep, 2019-10-28;9(1):15395.  2019-10-28
  55. Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer Cells
    Authors: R Leo, L Therachiyi, SK Siveen, S Uddin, M Kulinski, J Buddenkott, M Steinhoff, AR Krishnanku
    Cancers (Basel), 2019-10-01;11(10):.  2019-10-01
  56. Tissue-regenerative potential of the secretome of gamma-irradiated peripheral blood mononuclear cells is mediated via TNFRSF1B-induced necroptosis
    Authors: E Simader, L Beer, M Laggner, V Vorstandle, A Gugerell, M Erb, P Kalinina, D Copic, D Moser, A Spittler, E Tschachler, H Jan Ankers, M Mildner
    Cell Death Dis, 2019-09-30;10(10):729.  2019-09-30
  57. CLEFMA Activates the Extrinsic and Intrinsic Apoptotic Processes through JNK1/2 and p38 Pathways in Human Osteosarcoma Cells
    Authors: JS Yang, RC Lin, YH Hsieh, HH Wu, GC Li, YC Lin, SF Yang, KH Lu
    Molecules, 2019-09-09;24(18):.  2019-09-09
  58. Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1
    Authors: TND Pham, S Stempel, MA Shields, C Spaulding, K Kumar, DJ Bentrem, M Matsangou, HG Munshi
    Int J Mol Sci, 2019-09-02;20(17):.  2019-09-02
  59. Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors
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  63. Heme Oxygenase-1 is a Key Molecule Underlying Differential Response of TW-37-Induced Apoptosis in Human Mucoepidermoid Carcinoma Cells
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    Molecules, 2019-05-01;24(9):.  2019-05-01
  64. Investigation into the Molecular Mechanisms underlying the Anti-proliferative and Anti-tumorigenesis activities of Diosmetin against HCT-116 Human Colorectal Cancer
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  65. Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib
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  69. Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis
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    PLoS ONE, 2015-07-15;10(7):e0132407.  2015-07-15
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    PLoS ONE, 2015-05-01;10(5):e0125277.  2015-05-01
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    PLoS ONE, 2015-04-28;10(4):e0125490.  2015-04-28
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  113. ABCB5 is a limbal stem cell gene required for corneal development and repair.
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  114. B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection.
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Proteome Profiler Human Apoptosis Array Kit
By Gabriele Strusi on 11/21/2022

HepG2 cell lysate, 320 ug loaded, NIR LICOR secondary antibody

Proteome Profiler Human Apoptosis Array Kit
By Andres Ocampo on 10/11/2022

The kit was used in human SW480 colorectal adenocarcinoma cells treated with gold nanoparticles synthesized with Ricinus communis extracts. Several pro-apoptotic proteins were modulated by the nanoparticles, inducing apoptosis in the cells.

Proteome Profiler Human Apoptosis Array Kit
By Martin Torres on 09/23/2021

Apoptosis array was used to evaluate the pro-apoptotic effect of a South American berry on human colon adenocarcinoma cancer cells (SW480). The kit was very easy to use, all steps are very clear, and results were very consistent. These results were used for a manuscript that is currently under review. We definitively would buy this array to be assayed not only for cell culture but also for tissues.

The figure shown depicts the impact of three samples (Aspirin, the South American berry or ABJ, and their combination) in the modulation of pro-apoptotic proteins from this kit.

Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 10/20/2020

Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 02/07/2019

Proteome Profiler Human Apoptosis Array Kit
By Scott Scarneo on 12/12/2018

COLO 205 cancer cells were drug treated and vehicle and apoptosis proteins analyzed. 3 minute exposure time.

Proteome Profiler Human Apoptosis Array Kit
By Ivan Luzardo on 12/11/2018

Proteome Profiler Human Apoptosis Array Kit
By Ivan Luzardo on 12/11/2018

Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 09/13/2018

Very nice kit with easy to follow protocol. Good tool for discovery biology. We used to test small molecule induction of apoptosis in breast cancer cells. I would recommend this kit to anyone looking to profile multiple apoptosis pathways at once. Spot placement was very consistent which made analysis easy.

Proteome Profiler Human Apoptosis Array Kit
By Li Liu on 01/12/2018

Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 10/31/2017

Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 10/31/2017

Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 09/07/2017

Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 01/03/2017

This array is an excellent tool for screening potential apoptosis related targets. However, it would be nice that if more common targets can be included, e.g. tBid, cleaved PARP and cleaved Caspase9.

Proteome Profiler Human Apoptosis Array Kit
By Anonymous on 10/26/2015
Sample Tested: Tumor cell lyastes

These are arrays are used to determine the changes in the expression of proteins of different apoptotic pathways. The signal is quantified to detect the changes. Protocol instructions are good and easy to follow.
Specificity: Reasonably specific
Sensitivity: Reasonably sensitive
Buffer: BSA
Dilution: 1:1000