Shamain Dang, Bio-Techne Support Specialist - Cell Therapy and GMP Solutions chats with Yinfei Yin, Technical Director, Crown Bioscience. (from left to right)
Scientists from Crown Bioscience presented some of their latest data at the 2018 American Association of Cancer Research (AACR) in Chicago this month. The authors used Cultrex® Basement Membrane Extract in the development of a novel 3-D tumor...
The blood coagulation cascade is a complex and tightly regulated system that can either promote or inhibit clot formation. Maintaining the correct balance is vitally important. Ineffective coagulation (as in hemophilia) carries the risk of bleeding to death, while overactive coagulation results in blockage of blood vessels and tissue damage (as in atherosclerosis and stroke).
If your work involves the coagulation cascade or if you just want to learn about it, look through our Blood Coagulation interactive pathway. Clicking on the molecule links will take you to our premium quality reagents and assays related to that molecule. For more...
Bio-Techne was pleased to sponsor the 8th Annual Cancer Research Symposium, hosted by the Masonic Cancer Center at the University of Minnesota. This one-day conference featured exciting talks by luminaries in the cancer research field. Students and post-doctoral fellows presented the latest in their cancer research.
The keynote lecture "CAR T Cells for Cancer: The Next Generation" was given by Dr....
Our March 2018 Go Everywhere with Bio-Techne Travel Grant has been awarded to an Assistant Professor from Hong Kong Baptist University!
Bio-Techne's Go Everywhere Travel Grant Program awards $1000 USD (or equivalent) to one researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.
The recipient of the March 2018 grant is Hoi Leong Xavier Wong, a Research Assistant Professor in the School of Chinese Medicine at Hong Kong Baptist University!
...Bio-Techne is proud to announce the release of MimEX GI, a 3-D cell culturing platform for the generation of gastrointestinal tissue.
This new product line utilizes the unique...
Bio-Techne’s Go Everywhere Travel Grant Program awards $1000 USD (or equivalent) to one researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.
The recipient of the February 2018 grant is Daria Blokhina, a PhD Student in the Department of Pharmacology at the University of Helsinki in Finland!
Join our panel of experts Jean Stanton (J&J), John Tomtishen (Novartis), Dr. Sadik Kassim (Mustang Bio), and Dr. Diane Wotta (Bio-Techne) as they discuss: what GMP really means in the context of raw materials and ancillary reagents; the quality of raw materials required along the commercialization pathway; when to start using GMP materials; and the current regulatory landscape.
Learn more about R&D Systems GMP Proteins
We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.
A team of researchers at the University of Cambridge are developing an innovative way to repair heart tissue after a major heart attack: stem cell patches! Cardiomyocytes are...
In this webinar, Professor Bruce Walcheck discusses current approaches to augment antibody-dependent cell-mediated cytotoxicity (ADCC) by Natural Killer (NK) cells as therapies to treat cancer. This webinar also includes exciting research from his lab focused on generating enhanced versions of CD16A, an Fc receptor expressed by NK cells that recognizes tumor-targeting mAbs. Finally, his discussion covers the genetic manipulation of induced pluripotent stem cells (iPSCs) to derive NK cells engineered to express modified CD16A, and their potential for improving the efficacy of tumor-targeting therapeutic mAbs.
Key Topics:
Our website has a new set of interactive pathways that outline platelet activation, with each pathway focusing on a specific aspect of the process. Links within each pathway take you to our relevant product offerings to help you carry out the next steps in your platelet research. You’ll find recombinant proteins, antibodies, small molecules, and peptides, plus single- and multi-analyte immunoassays. Once you start clicking through our pathways, you’ll find some great tools and maybe some new ideas, too.
To navigate the pathways, click on the blue tabs at the left. They allow you to jump from one pathway to another. You can browse our complete collection of pathways here.
The amyloid cascade hypothesis theorizes that the excessive accumulation of Amyloid beta (A-beta) peptides in the brain are the initiating factor for the development of Alzheimer’s disease (AD). Specifically, that aggregates of A-beta peptides, which are formed following cleavage of the Amyloid Precursor Protein (APP), instigate a series of events that leads to neurodegeneration and, eventually, AD. This hypothesis arose from the observation that the plaques identified in brains afflicted with AD were composed largely of A-beta peptides, and was further supported by the finding that many AD risk and deterministic genes coded...
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We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.
A recent study in mice from Stanford University suggests that...
This video provides an overview of MimEX™ Tissue Model Systems, a next-generation 3-dimensional (3-D) cell culture platform for the generation of ex vivo epithelial-derived organ tissue. Learn the basics about how to incorporate this model system into your research, including how it compares to existing 3-D cell culture and organoid models. MimEX™ Tissue Model Systems harnesses the unique characteristics of adult ground-state epithelial stem cells to generate ex vivo organ tissue that recapitulates native cytoarchitecture and mimics physiological attributes of the desired organ. Consisting of optimized media and reagents, MimEX™ Tissue Model Systems provides an alternative to current 3-D cell culture modes, such as organoids, with the added benefit of...
MimEX™ Tissue Model Systems provide a robust system to generate accessible ex vivo 3-D tissue from epithelial-derived organs. This short video focuses on tips to optimize the differentiation of MimEX™ Tissue in an air-liquid interface. This includes helpful information on harvesting adult stem cells for differentiation, optimizing the setup of transwell inserts, and monitoring and identifying successful versus unsuccessful differentiation in the air-liquid interface system.
In this protocol you will learn:
Bio-Techne is honored to receive the CiteAb Researchers’ Choice Award for 2018! The annual awards aim to celebrate the very best suppliers and individuals in the research reagent sector worldwide.
The award of Researchers’ Choice reflects what researchers’ really think about the companies they get a wide range of reagents from for their work. It was noted that Bio-Techne...
Bio-Techne’s ProteinSimple-branded Ella™ platform has recently been added to the suite of advanced immunoassay technology at BioAgilytix, a leading provider of contract bioanalytical testing services with specialization in large molecule bioanalysis.
Ella joins her other immunoassay platform from ProteinSimple, PeggySue®, along with several other bioanalytical technologies and automation systems in the BioAgilytix core immunoassay services in their laboratories....
This protocol video describes the MimEX™ Cell Plating Procedure. This procedure is important when using the MimEX™ Tissue Model System from R&D Systems. First, the MimEX™ Cell Plating Procedure is used to maintain a uniform irradiated fibroblast monolayer for the rapid clonal expansion and efficient differentiation of tissue-specific adult epithelial stem cells. It is also used to optimize the seeding distribution of adult stem cells on top of the fibroblasts monolayer. This distribution helps to maintain the health and rapid proliferation rate of adult epithelial stem cells using MimEX™ Tissue Model Systems.
Briefly, the cell plating procedure consists of three shakes of the plate backward and forward and three shakes of the plate side-to-side. This procedure is repeated three times before...
Mass cytometry, or CyTOF, is a variation of flow cytometry in which antibodies are labeled with heavy metal ion tags rather than fluorochromes. Readout is by time-of-flight mass spectrometry. This allows for the combination of many more antibodies (over 30) for phenotypic profiling and functional analysis of single cells, without significant overlap between channels. Mass cytometry has now been applied to various research areas including basic immunology, neuroscience, immuno-oncology, drug discovery, and stem cell research. While mass cytometry offers a powerful and highly multiplexed method for profiling single cells, there are various technical considerations for researchers wanting to perform a mass cytometry assay for the first time, or at a more advanced level. These steps include experimental planning, sample and reagent preparation,...
We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.
For the first time, trophoblast stem cells have been isolated and cultured by researchers in Japan. These cells line the outer layer of the blastocyst and eventually become...
Regulatory T cells (Tregs) are a unique subset of CD4+ T cells with immunosuppressive properties. As a result, they are currently being investigated as a cellular therapeutic for the treatment of autoimmune diseases and long-term patient and graft survival following solid organ transplantation, and allogeneic hematopoietic stem cell transplantation. Studies in animal models suggest that the success of Treg cell therapy relies on the presence of a high number of Tregs in order to suppress the activities of effector T cells. Since the frequency of Tregs in the peripheral blood is low, Treg cell therapy typically requires that Tregs be isolated and expanded...
By Erin Christey, Simple Plex Product Manager
Optimizing therapies for patients with Hodgkin lymphoma relies upon the identification of prognostic factors that will predict outcomes and guide treatment approaches. A cross-departmental group at the Memorial Sloan Kettering Cancer Center recently published their findings on how baseline metabolic tumor volume is a predictive factor for patients with relapsed/refractory Hodgkin lymphoma.
Following standards set by the Clinical Laboratory Improvement...
Prostate cancer (PCa) is the most common noncutaneous malignancy in men in the US. A significant fraction of advanced PCa treated with androgen deprivation therapy experience relentless progression to lethal metastatic castration-resistant prostate cancer (mCRPC). The PCa tumor microenvironment is comprised of a complex mixture of epithelial and stroma cell types engaged in multifaceted heterotypic interactions functioning to maintain tumor growth and immune evasion. We recently uncovered the important role played by myeloid-derived suppressor cells (MDSCs) to mediate tumor immune evasion in aggressive PCa. Although, Immune checkpoint blockade (ICB) has elicited durable therapeutic responses across a number of cancer types, its...
This protocol video demonstrates how to surface-coat cell culture plates and transwell inserts with Cultrex® Basement Membrane Extract, also called Cultrex® BME. Cultrex® BME is an extracellular matrix scaffold commonly used in stem cell culture and 3-dimensional (3-D) cell culture protocols, such as organoids and MimEX™ Tissue Model Systems. Using Cultrex® BME, MimEX™ Tissue Models System provides a platform for the isolation, expansion, and differentiation of adult epithelial stem cells into 3-D ex vivo organ tissue.
In this protocol you will learn:
Bio-Techne has announced a new offering of reagents and kits from Vector Laboratories, a leader in labeling and detection solutions. Beginning in October 2017, Bio-Techne began to distribute Vector Laboratories products to complement the over 40,000 primary antibodies from Novus Biologicals® validated for immunocytochemistry and immunohistochemistry.
Vector...
