Fetal Bovine Serum (FBS), also known as fetal calf serum (FCS), is the ideal cell growth supplement and generally preferred over other types of cell culture sera. The significantly lower content of antibodies compared to adult and newborn sera minimizes the risk of antibody cross reaction with cells in culture. It’s high level of nutrients and optimal combination of growth factors makes Fetal Bovine Serum the most effective cell growth promoter for virtually any cell culture system.Standard Grades of FBS Specialty Grades of FBS FBS Quality Which FBS Should I Use?
Standard Grades for Fetal Bovine Serum (FBS)
Keeping your cell culture requirements in mind, we offer several grades of fetal bovine serum to support a broad spectrum of culture needs. All standard grades of fetal bovine serum are also available heat inactivated.
|Grade of Fetal Bovine Serum||Material Origin||Additional Features||Heat Inactivated Available?||Gamma Irradiated Available?|
|Premium Grade Fetal Bovine Serum||USDA-approved FBS||The most affordable grade of fetal bovine serum.||Yes|
|Optima Grade Fetal Bovine Serum||US Origin FBS, USDA-Aphis certified||Additional extensive biochemical profile and extended virus testing to provide piece of mind for our serum users. It also includes a comprehensive quality assurance testing.||Yes||Yes|
|Premium Select Grade Fetal Bovine Serum||USDA-approved FBS||The highest quality FBS grade. Additional extensive hormone profiling, biochemical analysis, and rigorous viral testing for specific research applications requiring this data.||Yes||Yes|
Specialty Grades of Fetal Bovine Serum (FBS)
In addition to our standard grades of fetal bovine serum, R&D Systems also offers specialty grades of fetal bovine serum. These sera have been selected for specialty cell culture applications such as embryonic stem cell cultures, hybridoma technology, TET systems and cell lines, and more. All our specialty grades of fetal bovine serum as also available heat inactivated.Request a Sample
|Specialty Fetal Bovine Serum||Material Origin||Additional Features||Heat Inactivated Available?|
|Embryonic Stem Cell Qualified Fetal Bovine Serum||USDA-approved FBS||Removes the need for time-consuming pre-screening of multiple lots of serum. This specialty fetal bovine serum ensures stability when culturing embryonic stem cells by screening for plating efficiency, colony morphology, and cytotoxicity, while also maintaining cells in their undifferentiated state.||Yes|
|Hybridoma Qualified Fetal Bovine Serum||USDA-approved FBS||Designed for the culture of hybridoma and myeloma cells. This specialty FBS has been screened to show superior growth at limiting dilutions and lack of cytotoxicity in growth studies.||Yes|
|TET Tested Fetal Bovine Serum||USDA-approved FBS||Designed for use in TET-driven gene expression systems and cell lines. Only lots with undetectable TET levels throughout serum production are selected as TET Tested Fetal Bovine Serum.||Yes|
|Charcoal/Dextran Treated Fetal Bovine Serum||US Origin FBS, USDA-approved FBS||Designed for use in cultures requiring lower levels of hormones, steroids, or growth factors in serum, such as paracrine and endocrine signaling. This specialty FBS is screened for various hormones and steroids before and after treatment.||Yes|
|Dialyzed Fetal Bovine Serum||US Origin FBS||Designed for use in cell culture systems requiring reduced concentrations of low molecular weight components, such as nucleotides, amino acids, hormones, salts, and small proteins. This serum is dialyzed against physiological saline using a 12 – 14 kiloDalton (kDa) cutoff membrane using a controlled process where glucose concentration is precisely monitored throughout the procedure. Exhaustive dialysis is not performed in order to prevent precipitation and inactivation of serum peptides.||Yes|
|Gamma Irradiated Fetal Bovine Serum||US Origin and USDA-approved||Gamma irradiation is an effective method of inactivating viruses and other adventitious agents that may exist at low levels in serum. Gamma irradiated Optima and Premium Select FBS are exposed to a Cobalt source, delivered at a dose of 25-40 kGy, which removes up to 6 logs of contaminating biological agents, while preserving the growth performance characteristics of serum. Gamma irradiated FBS offers greater assurance that the existence of low-level microbial contamination is reduced and the risks associated with animal-derived components is minimized.||Yes|
R&D Systems offers a wide variety of fetal bovine serum, manufactured at our ISO 9001:2105 certified facility, to support general cell culture, stem cell cultures, and many other specialized cell culture needs. We have USDA APHIS-certified, US Origin, and USDA-approved grades of FBS. We recognize the vital impact of quality fetal bovine serum for today’s evolving cell culture technology, and we're proud to have an established network of raw materials to ensure direct control over all processes involved in the manufacture of our fetal bovine serum.