Human AHR Antibody

Catalog # Availability Size / Price Qty
AHR in Human Pancreatic Cancer Tissue.
1 Image
Product Details
Citations (1)
Supplemental Products

Human AHR Antibody Summary

Species Reactivity
Detects human AHR in direct ELISAs.
Monoclonal Mouse IgG1 Clone # 684217
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant human AHR
Accession # P35869
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Immunohistochemistry AHR antibody in Human Pancreatic Cancer Tissue by Immunohistochemistry (IHC-P). View Larger

AHR in Human Pancreatic Cancer Tissue. AHR was detected in immersion fixed paraffin-embedded sections of human pancreatic cancer tissue using Mouse Anti-Human AHR Monoclonal Antibody (Catalog # MAB6185) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to epithelial cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: AHR

AHR (Aryl-Hydrocarbon Receptor), also known as bHLHE76, is a 110 kDa member of the bHLH/PAS transcription factor family. It is widely expressed (breast, lung, liver), and serves many functions. First, it binds multiple xenobiotic chemicals in the cytoplasm. This induces dimerization with ARNT, translocation to the nucleus, and activation of P450 genes such as CYP1A1 and UGT1A6. Second, it appears to block cell cycle progression, possibly via a down‑regulation of CDK proteins. And third, it blocks apoptosis by interacting with E2F1, thus silencing TP73 and Apaf1 genes. Human AHR is 848 amino acids (aa) in length. It contains a 10 aa prosegment, plus a 838 aa mature molecule that contains a DNA binding motif (aa 13-40), a bHLH region (aa 41-81), and two PAS domains (aa 111-342). Over aa 704-848, human AHR shares 70% aa identity with mouse AHR.

Long Name
Aryl Hydrocarbon Receptor
Entrez Gene IDs
196 (Human); 11622 (Mouse); 25690 (Rat)
Alternate Names
Ah receptor; AHR; AH-receptor; aryl hydrocarbon receptor; BHLHE76; bHLHe76aromatic hydrocarbon receptor; Class E basic helix-loop-helix protein 76

Product Datasheets

Citation for Human AHR Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Aryl hydrocarbon receptor ligands enhance lung immunity through intestinal IKK β pathways
    Authors: TB Tsay, PH Chen, LW Chen
    J Transl Med, 2019;17(1):304.
    Species: Mouse
    Sample Types: Protein
    Applications: Western Blot


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Immunohistochemistry Reagents

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Secondary Antibodies

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