Human Angiostatin Kringle 1-3 Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (1)
Supplemental Products

Human Angiostatin Kringle 1-3 Antibody Summary

Species Reactivity
Detects human Angiostatin Kringle 1-3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody also detects plasminogen but does not cross-react with recombinant mouse Angiostatin.
Monoclonal Mouse IgG2A Clone # 79735
Protein A or G purified from ascites
E. coli-derived recombinant human Angiostatin Kringle 1-3
Val98-Ser358 (Cys88Ser, Cys316Ser)
Accession # P00747
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Human Angiostatin Kringle 1-3

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Angiostatin

Plasminogen is the precursor of plasmin, an active serine protease that dissolves the fibrin of blood clots and acts in many other processes such as embryonic development, tissue remodeling, inflammation and tumor invasion. Synthesized in the kidney, plasminogen is found in plasma and many extracellular fluids. Activated by u- or t-plasminogen activator, the single-chain plasminogen is converted to plasmin that consists of a disulfide bond-linked heavy chain A and light chain B. Heavy chain A contains 5 kringle domains and light chain B corresponds to the serine protease domain. A fragment consisting of the first 4 kringle domains has been named angiostatin, a novel angiogenesis inhibitor.

Entrez Gene IDs
5340 (Human); 18815 (Mouse)
Alternate Names
Angiostatin; HAE4

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Citation for Human Angiostatin Kringle 1-3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Adeno-associated virus 2-mediated antiangiogenic cancer gene therapy: long-term efficacy of a vector encoding angiostatin and endostatin over vectors encoding a single factor.
    Authors: Ponnazhagan S, Mahendra G, Kumar S, Shaw DR, Stockard CR, Grizzle WE, Meleth S
    Cancer Res., 2004;64(5):1781-7.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development


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Isotype Controls

Mouse IgG2A Isotype Control

Reconstitution Buffers

Secondary Antibodies

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