Human BMPR-II Antibody
Human BMPR-II Antibody Summary
Ala26-Ile151
Accession # Q13873
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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BMPR-II in Human Prostate. BMPR-II was detected in formalin fixed paraffin-embedded sections of human prostate using Goat Anti-Human BMPR-II Antigen Affinity-purified Polyclonal Antibody (Catalog # AF811) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the plasma membrane of epithelial cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
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Detection of BMPR‑II in PC‑3 Human Cell Line by Flow Cytometry. PC-3 human prostate cancer cell line was stained with Goat Anti-Human BMPR-II Antigen Affinity-purified Polyclonal Antibody (Catalog # AF811, filled histogram) or control antibody (Catalog # AB-108-C, open histogram), followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0108).
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: BMPR-II
Like other members of the TGF-beta superfamily, cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the binding to heteromeric complex of type I and type II serine-threonine kinase receptors. Both receptor types are required for the signal transduction. BMP receptor II (BMPR-II) is one of the five mammalian type II receptors (including TGF-beta R-II, ActR-II, ActR-IIB, BMPR-II, and MISR-II) for the TGF-beta superfamily ligands. The type II receptors for TGF-beta and activin bind ligands with high affinity by itself. In contrast, BMPR-II binds BMP-2, BMP-4, and BMP-7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor. BMPR-II mRNA is widely expressed in fetal and adult tissues. Human and mouse BMPR-II are highly conserved sharing 97% sequence identity (1-3).
- Rosenzweig, B.L. et al. (1995) Proc. Natl. Acad. Sci. USA 92:7632.
- Beppu, H. et al. (1997) Biochem. Biophys. Res. Commun. 235:499.
- Kawabata, M. et al. (1998) Cytokine and Growth Factor Reviews 9:49.
Product Datasheets
Citations for Human BMPR-II Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth
Authors: SV Hegarty, AM Sullivan, GW O'Keeffe
Neurosci. Lett, 2017;643(0):32-37.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
BMP4 is a peripherally-derived factor for motor neurons and attenuates glutamate-induced excitotoxicity in vitro.
Authors: Chou H, Lai D, Huang C, McLennan I, Wang H, Wang P
PLoS ONE, 2013;8(3):e58441.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro.
Authors: Fong D, Bisson M, Laberge G, McManus S, Grenier G, Faucheux N, Roux S
Cell Signal, 2013;25(4):717-28.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma.
Authors: Wang Y, Kahaleh B
J Cell Mol Med, 2013;17(10):1291-9.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Bone morphogenetic protein receptor IB as a marker for enrichment of osteogenic precursor-like cells in human dermis.
Authors: He J, Dong J, Wang T
Arch. Dermatol. Res., 2011;303(8):581-90.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2.
Authors: Yao Y, Shao ES, Jumabay M, Shahbazian A, Ji S, Bostrom KI
Arterioscler. Thromb. Vasc. Biol., 2008;28(12):2266-74.
Species: Human
Sample Types: Whole Cells
Applications: Western Blot -
Cell origin in experimental repair of cricoid cartilage defects treated with recombinant human bone morphogenetic protein-2.
Authors: Tcacencu I, Carlsoo B, Stierna P
Wound Repair Regen, 2005;13(3):341-9.
Species: Rabbit
Sample Types: Whole Tissue
Applications: IHC
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