Human Carboxypeptidase B1/CPB1 Antibody
Human Carboxypeptidase B1/CPB1 Antibody Summary
Accession # P15086
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Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Carboxypeptidase B1/CPB1
Carboxypeptidase B1, encoded by the CPB1 gene, specifically cleaves the C-terminal Arg and Lys residues with a preference for Arg (1). Expressed mainly in pancreas, CPB1 is a useful serum marker for acute pancreatitis (2). The deduced amino acid (aa) sequence of human CPB1 consists of a signal peptide (aa 1-15), a pro region (aa 16-110), and a mature chain (aa 111-417). Human CPB1 shares 98%, 84%, 76%, 75%, and 84% aa sequence identity with chimpanzee, dog, rat, mouse and chicken CPB1, respectively.
- Aviles, F.X. and J. Vendrell (2004) in Handbook of Proteolytic Enzymes (ed. Barrett, A.J. et al.) p. 831, Academic Press, San Diego.
- Yamamoto, K.K. et al. (1992) J. Biol. Chem. 267:2575.
Citations for Human Carboxypeptidase B1/CPB1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models
Authors: J Beumer, J Bauzá-Mart, TS Veth, V Geurts, C Boot, H Gilliam-Vi, SS Poulsen, FK Knop, W Wu, H Clevers
Proceedings of the National Academy of Sciences of the United States of America, 2022;119(46):e2212057119.
Sample Types: Organoid
Fecal host biomarkers predicting severity of Clostridioides difficile infection
Authors: M Golizeh, K Winter, L Roussel, M Landekic, M Langelier, VG Loo, M Ndao, DC Vinh
JCI Insight, 2020;0(0):.
Sample Types: Protein
Applications: Western Blot
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