Human ENPP-2/Autotaxin Antibody
Human ENPP-2/Autotaxin Antibody Summary
Accession # Q13822
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40-50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain (1). Unlike ENPP-1 and ENPP-3, ENPP-2 has weak activity against nucleotides, but exhibits a lysophospholipase D activity which allows the formation of lysophosphatidic acid (LPA) and choline from lysophosphatidylcholine (2). The hydrolysis of nucleotides and lysophospholipids by ENPP-2 is mediated by a single catalytic site (2). Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2 (3). ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis (4) and to be up-regulated in several types of carcinomas including breast and lung (5).
- Cimpean, A. et al. (2004) Biochem. J. 381:71.
- Gijsbers, R. et al. (2003) FEBS Letters. 538:60.
- Van Meeteren, L.A. et al. (2005) J. Biol. Chem. 280:21155.
- Nam, S.W. et al. (2000) Oncogene 19:241.
- Jansen, S. et al. (2005) J. Cell Sci. 118:3081.
Product Specific NoticesThis product may be covered by one or more of the following US issued patents 5,449,753; 5,731,167; 6,084,069; 6,417,338 and US pending applications.
Citation for Human ENPP-2/Autotaxin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
The polybasic insertion in autotaxin alpha confers specific binding to heparin and cell surface heparan sulfate proteoglycans.
Authors: Houben A, van Wijk X, van Meeteren L, van Zeijl L, van de Westerlo E, Hausmann J, Fish A, Perrakis A, van Kuppevelt T, Moolenaar W
J Biol Chem, 2013;288(1):510-9.
Sample Types: Recombinant Protein
Applications: ELISA Development
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