Human FGFR1 (IIIb) Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
FGF R1 alpha Inhibition of FGF acidic-dependent Cell Proliferation and Neutralization by Human FGF R1 Antibody. Recombinant Human FGF R1a (IIIb) Fc Chimera (Catalog # 655-FR) inhibits Recombinant Human FGF acidic (Catalog # 232-FA) induced proliferation in the NR6R‑3T3 mouse fibroblast cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Human FGF acidic (0.3 ng/mL) activity elicited by Recombinant Human FGF R1a (IIIb) Fc Chimera (6 ng/mL) is neutralized (green line) by increasing concentrations of Human FGF R1 (IIIb) Monoclonal Antibody (Catalog # MAB765). The ND50 is typically 0.075-0.3 µg/mL in the presence of heparin (10 µg/mL).
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
FGF R1 occurs as multiple isoforms. The extracellular domain consists of three ( alpha isoforms) or two ( beta isoforms) immunoglobulin-like domains. In addition, the membrane-proximal Ig-like domain can be encoded by alternative exons yielding (IIIb) or (IIIc) isoforms.
Citations for Human FGFR1 (IIIb) Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c.
Authors: Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I
Stem Cells, 2012;30(7):1455-64.
Sample Types: Whole Cells
Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase.
Authors: Zemskov EA, Loukinova E, Mikhailenko I, Coleman RA, Strickland DK, Belkin AM
J. Biol. Chem., 2009;284(24):16693-703.
Sample Types: Whole Cells
Why is heparin necessary in the neutralization assay using Human FGFR1 (IIIb) Antibody, Catalog # MAB765?
The heparin is a necessary cofactor for the binding of FGF to the receptor which induces the proliferation that this antibody neutralizes.
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