Human MAVS Antibody Summary
Accession # Q7Z434
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
MAVS in Human Kidney. MAVS was detected in immersion fixed paraffin-embedded sections of human kidney using Mouse Anti-Human MAVS Monoclonal Antibody (Catalog # MAB9694) at 1.7 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in convoluted tubules. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Mitochondrial antviral signaling protein (MAVS, also known as IPS-1, VISA, and CARDIF) is a ubiquitous, tail-anchored membrane protein inserted in the outer mitochondrial membrane (OMM), and is also found in the peroxisomal membrane and the mitochondrial associated membrane of the endoplasmic reticulum. Peroxisomal MAVS has been implicated in type II IFN-dependent antiviral response, while mitochondrial MAVS mediates longer lasting type I IFN dependent antiviral response. Mitochondrial reactive oxygen species (mROS) induce oligomerization of MAVS in the outer membrane plane of mitochondria to induce innate immunity to viral infection. MAVS undergoes RIG-I-like receptors (RLR)-induced formation of higher order structures ranging from dimers to prion-like aggregates that lead to the recruitment and activation of signaling proteins culminating in the activation of the transcription factors IRF-3 and NF-kappa B and transcription of IFNs
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