Human MAVS Antibody

Catalog # Availability Size / Price Qty
MAB9694-100
MAB9694-SP
MAVS in Human Kidney.
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Human MAVS Antibody Summary

Species Reactivity
Human
Specificity
Detects human MAVS in direct ELISAs.
Source
Monoclonal Mouse IgG2B Clone # 981240
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E.coli-derived recombinant human MAVS
Arg37-Pro513
Accession # Q7Z434
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
1-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Immunohistochemistry MAVS antibody in Human Kidney by Immunohistochemistry (IHC-P). View Larger

MAVS in Human Kidney. MAVS was detected in immersion fixed paraffin-embedded sections of human kidney using Mouse Anti-Human MAVS Monoclonal Antibody (Catalog # MAB9694) at 1.7 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in convoluted tubules. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: MAVS

Mitochondrial antviral signaling protein (MAVS, also known as IPS-1, VISA, and CARDIF) is a ubiquitous, tail-anchored membrane protein inserted in the outer mitochondrial membrane (OMM), and is also found in the peroxisomal membrane and the mitochondrial associated membrane of the endoplasmic reticulum. Peroxisomal MAVS has been implicated in type II IFN-dependent antiviral response, while mitochondrial MAVS mediates longer lasting type I IFN dependent antiviral response. Mitochondrial reactive oxygen species (mROS) induce oligomerization of MAVS in the outer membrane plane of mitochondria to induce innate immunity to viral infection. MAVS undergoes RIG-I-like receptors (RLR)-induced formation of higher order structures ranging from dimers to prion-like aggregates that lead to the recruitment and activation of signaling proteins culminating in the activation of the transcription factors IRF-3 and NF-kappa B and transcription of IFNs

Long Name
Mitochondrial Antiviral Signaling Protein
Entrez Gene IDs
57506 (Human); 228607 (Mouse); 311430 (Rat)
Alternate Names
CARD adapter inducing interferon beta; CARD adapter inducing interferon-beta; CARD adaptor inducing IFN-beta; Cardif; DKFZp547C224; DKFZp666M015; FLJ27482; IFN-B promoter stimulator 1; Interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS-1; IPS-1FLJ41962; IPS1MGC3260; KIAA1271FLJ35386; MAVS; mitochondrial antiviral signaling protein; mitochondrial antiviral-signaling protein; mitochondrial viral signaling protein; Putative NF-kappa-B-activating protein 031N; virus-induced signaling adapter variant 1b; virus-induced signaling adaptor variant 1a; Virus-induced-signaling adapter; VISA; VISAFLJ38051

Product Datasheets

FAQs

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

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