Human MMP-11 Antibody
Human MMP-11 Antibody Summary
Accession # P24347
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
MMP-11, also called Stromelysin-3, is a metalloproteinase secreted by cells of mesenchymal origin. Human MMP-11 contains a 31 amino acid (aa) signal sequence, a 65 aa propeptide cleaved at a furin consensus sequence, and a 390 aa mature sequence with zinc metalloproteinase and hemopexin-like domains. The human 45 kDa mature MMP-11 shows 89% aa identity with mouse. An inducible low-abundance 40 kDa isoform is a constitutively active intracellular form. MMP-11 is upregulated in stromal cells near many invasive carcinomas, where it can cleave IGFBP, allowing IGF-1 to promote tumor cell growth.
Citation for Human MMP-11 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors
Authors: V Borgna, L Lobos-Gonz, F Guevara, E Landerer, M Bendek, R Ávila, V Silva, C Villota, M Araya, A Rivas, C López, T Socias, J Castillo, L Alarcón, LO Burzio, VA Burzio, J Villegas
J Cancer, 2020;11(7):1780-1791.
Sample Types: Cell Culture Lysates
Applications: Western Blot
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Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma