Human MMP-11 Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (1)
Supplemental Products
Reviews (4)

Human MMP-11 Antibody Summary

Species Reactivity
Detects human MMP-11 in direct ELISAs.
Monoclonal Mouse IgG2B Clone # 135421
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant human MMP‑11
Accession # P24347
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
Intracellular Staining by Flow Cytometry
2.5 µg/106 cells
HepG2 human hepatocellular carcinoma cell line fixed with paraformaldehyde and permeabilized with saponin

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: MMP-11

MMP-11, also called Stromelysin-3, is a metalloproteinase secreted by cells of mesenchymal origin. Human MMP-11 contains a 31 amino acid (aa) signal sequence, a 65 aa propeptide cleaved at a furin consensus sequence, and a 390 aa mature sequence with zinc metalloproteinase and hemopexin-like domains. The human 45 kDa mature MMP-11 shows 89% aa identity with mouse. An inducible low-abundance 40 kDa isoform is a constitutively active intracellular form. MMP-11 is upregulated in stromal cells near many invasive carcinomas, where it can cleave IGFBP, allowing IGF-1 to promote tumor cell growth.

Long Name
Matrix Metalloproteinase 11
Entrez Gene IDs
4320 (Human)
Alternate Names
EC 3.4.24; EC 3.4.24.-; EC; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3); Matrix metalloproteinase-11; MMP11; MMP-11; SL-3; ST3; STMY3stromelysin 3; stromelysin III; stromelysin-3

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Citation for Human MMP-11 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Targeting antisense mitochondrial noncoding RNAs induces bladder cancer cell death and inhibition of tumor growth through reduction of survival and invasion factors
    Authors: V Borgna, L Lobos-Gonz, F Guevara, E Landerer, M Bendek, R Ávila, V Silva, C Villota, M Araya, A Rivas, C López, T Socias, J Castillo, L Alarcón, LO Burzio, VA Burzio, J Villegas
    J Cancer, 2020;11(7):1780-1791.
    Species: Human
    Sample Types: Cell Culture Lysates
    Applications: Western Blot


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Secondary Antibodies

Reviews for Human MMP-11 Antibody

Average Rating: 4.3 (Based on 4 Reviews)

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Human MMP-11 Antibody
By Anonymous on 01/14/2021
Application: Microarrays Sample Tested: EDTA Plasma Species: Human

Human MMP-11 Antibody
By Anonymous on 02/07/2020
Application: MiAr Sample Tested: EDTA Plasma Species: Human

Antibody was printed on custom arrays and incubated with fluorescently labeled human EDTA plasma

Human MMP-11 Antibody
By Anonymous on 11/14/2018
Application: Microarrays Sample Tested: EDTA Plasma Species: Human

Human MMP-11 Antibody
By Anonymous on 11/11/2018
Application: ELISA Sample Tested: Serum and Plasma Species: Human