Human/Mouse BMPR-IB/ALK-6 Antibody

Catalog # Availability Size / Price Qty
MAB505-SP
MAB505-500
MAB505-100
Product Details
Citations (6)
FAQs
Supplemental Products
Reviews

Human/Mouse BMPR-IB/ALK-6 Antibody Summary

Species Reactivity
Human, Mouse
Specificity
Detects human and mouse BMPR-IB/ALK-6 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross‑reactivity with recombinant mouse (rm) BMPR‑IB and no cross‑reactivity with recombinant human (rh) BMPR‑IA, rmBMPR‑IA, or rhBMPR‑II is observed.
Source
Monoclonal Mouse IgG2A Clone # 88614
Purification
Protein A or G purified from ascites
Immunogen
Mouse myeloma cell line NS0-derived recombinant human BMPR-IB/ALK-6
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human BMPR-IB/ALK‑6 Fc Chimera (Catalog # 505-PR)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: BMPR-IB/ALK-6

BMPR-IB, also known as ALK-6, is a type I serine/threonine kinase receptor that associates with a type II TGF-beta receptor superfamily member to form a heteromeric signaling receptor complex. BMPR-IB is expressed during embryogenesis and in adult brain, bone, and hematopoietic stem cells.

Long Name
Bone Morphogenetic Protein Receptor IB
Entrez Gene IDs
658 (Human); 12167 (Mouse)
Alternate Names
activin receptor-like kinase 6; ALK-6; ALK6CDw293; BMP type-1B receptor; BMPR1B; BMPR-1B; BMPRIB; BMPR-IB; bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293 antigen; CDw293; EC 2.7.11; EC 2.7.11.30; serine/threonine receptor kinase

Product Datasheets

Citations for Human/Mouse BMPR-IB/ALK-6 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection.
    Authors: Beckham JD, Tuttle K, Tyler KL
    J. Virol., 2009;83(10):5035-45.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: WB
  2. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.
    Authors: Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY
    J. Mol. Biol., 2008;381(4):1025-39.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Development
  3. Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.
    Authors: Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW
    J. Pathol., 2008;214(1):85-95.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  4. Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia.
    Authors: Alejandre-Alcazar MA, Kwapiszewska G, Reiss I, Amarie OV, Marsh LM, Sevilla-Perez J, Wygrecka M, Eul B, Kobrich S, Hesse M, Schermuly RT, Seeger W, Eickelberg O, Morty RE
    Am. J. Physiol. Lung Cell Mol. Physiol., 2007;292(2):L537-49.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: WB
  5. Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach.
    Authors: Bleuming SA, Kodach LL, Garcia Leon MJ, Richel DJ, Peppelenbosch MP, Reitsma PH, Hardwick JC, van den Brink GR
    J. Pathol., 2006;209(2):190-7.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC Paraffin-embedded
  6. Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism.
    Authors: Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller ET
    Cancer Res., 2005;65(18):8274-85.
    Species: Human
    Sample Types: Cell Lysates
    Applications: WB

FAQs

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Isotype Controls

Mouse IgG2A Isotype Control

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Reconstitution Buffers

Secondary Antibodies

Mouse IgG2A Antibody

Mouse IgG2A Antibody

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