MUCDHL in Human Kidney. MUCDHL was detected in immersion fixed paraffin-embedded sections of human kidney using 15 µg/mL Goat Anti-Human MUCDHL Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3826) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the plasma membrane of epithelial cells in collecting tubules. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
Reconstitute at 0.2 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Mucin and cadherin-like protein (MUCDHL), also known as μ-protocadherin, is a 110 kDa type I transmembrane protein that is both O- and N-glycosylated. It is a calcium-dependant cell adhesion protein in the cadherin superfamily. MUCDHL is found on intestinal and renal epithelium. Human MUCDHL extracellular domain (ECD) contains four cadherin domains (residues 71-459) plus several mucin domains (residues 540-645). Alternate splicing creates four isoforms that differ in their mucin domains. In the region used as immunogen, human and mouse MUCDHL share 63% amino acid sequence identity.
Mucin And Cadherin-like
Entrez Gene IDs:
53841 (Human); 72040 (Mouse); 171554 (Rat)
cadherin-related family member 5; CDHR5; FLJ20219; MUCDHL; MUCDHLmucin-like protocadherin; Mucin and cadherin-like protein; mucin and cadherin-like; MUPCDH; MU-PCDH; mu-protocadherin
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