Human Nectin-4 Antibody
Human Nectin-4 Antibody Summary
Accession # Q96NY8
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Nectin-4 is a type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. It is both a homophilic and heterophilic (with Nectin-1) cell adhesion molecule that is expressed in the embryo and in breast carcinoma. A soluble form of Nectin-4 is generated from the membrane protein via the action of TACE/ADAM-17. The extracellular domain of human Nectin-4 shares 90% and 92% amino acid sequence homology with the corresponding regions of mouse and rat Nectin-4, respectively.
Citations for Human Nectin-4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
J. Biol. Chem, 2017;0(0):.
Sample Types: Whole Cells
Applications: Flow Cytometry
A role for PVRL4-driven cell-cell interactions in tumorigenesis.
Authors: Pavlova N, Pallasch C, Elia A, Braun C, Westbrook T, Hemann M, Elledge S
Sample Types: Whole Cells
Applications: Functional Assay
Nectin 4 overexpression in ovarian cancer tissues and serum: potential role as a serum biomarker.
Authors: Derycke MS, Pambuccian SE, Gilks CB
Am. J. Clin. Pathol., 2010;134(5):835-45.
Sample Types: Cell Lysates
Applications: Western Blot
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Detection of NECTIN4 in human breast cancer cell line. SKBR3 cells were stained with 67 nM of the Human Nectin-4 Antibody (Catalog # MAB2659) or mouse IgG2b isotype control, followed by a secondary goat a-mouse IgG Fc APC antibody. Unstained cells (Red), secondary goat a-mouse IgG Fc APC antibody alone (Blue), mouse IgG2b isotype plus secondary antibody (Orange), Human Nectin-4 Antibody (Catalog # MAB2659) plus secondary antibody (Green).