Human Plexin B1 Antibody

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Product Details
Citations (5)
Supplemental Products
Reviews (1)

Human Plexin B1 Antibody Summary

Species Reactivity
Detects human Plexin B1 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human Plexin B3 is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
E. coli-derived recombinant human Plexin B1
Accession # O43157
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human Plexin B1
5-15 µg/mL
Immersion fixed paraffin-embedded sections of human prostate

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Plexin B1

Plexin B1 is a type I transmembrane protein that belongs to the Plexin family of semaphorin receptors. It is derived from a single peptide that undergoes proteolytic processing in its extracellular domain to form the non-covalently-linked heterodimer of the extracellular alpha subunit and the transmembrane beta subunit. Human Plexin B1 extracellular alpha subunit shares homology with semaphorins, HGF receptor and MSP receptor and contains a sema domain and three IPT/TIG domains. It functions as a receptor for semaphorin 4D/CD100. Multiple splice isoforms of Plexin B1 have been reported. Within the region used as immunogen, human Plexin B1 shares 90% and 97% amino acid sequence homology with mouse and canine Plexin B1, respectively.

Entrez Gene IDs
5364 (Human); 235611 (Mouse); 316009 (Rat)
Alternate Names
Plexin B1; PLXN5; PLXNB1; SEP; Transmembrane Protein SEP

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Citations for Human Plexin B1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
    Authors: Yong Huang, Rut Tejero, Vivian K. Lee, Concetta Brusco, Theodore Hannah, Taylor B. Bertucci et al.
    Communications Biology
  2. The IkappaB kinase complex is required for plexin-B-mediated activation of RhoA.
    Authors: Zielonka M, Krishnan R, Swiercz J, Offermanns S
    PLoS ONE, 2014-08-19;9(8):e105661.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  3. Grb2 mediates semaphorin-4D-dependent RhoA inactivation.
    Authors: Sun, Tianlian, Krishnan, Rameshku, Swiercz, Jakub M
    J Cell Sci, 2012-04-14;125(0):3557-67.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis.
    Authors: Worzfeld T, Swiercz JM, Looso M
    J. Clin. Invest., 2012-03-01;122(4):1296-305.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  5. ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.
    Authors: Swiercz JM, Worzfeld T, Offermanns S
    J. Biol. Chem., 2007-11-19;283(4):1893-901.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation, Western Blot


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Human Plexin B1 Antibody
By Yong Huang on 11/23/2016
Application: WB Sample Tested: E11.5 mouse whole embryo lysate Species: Mouse