Human RELT/TNFRSF19L Antibody Summary
Ser26-Ala160 (Arg127Gly, Arg129Gly)
Accession # Q969Z4
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human RELT/TNFRSF19L by Western Blot. Western blot shows lysates of human bone marrow tissue and human lymph node tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human RELT/TNFRSF19L Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1385) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for RELT/TNFRSF19L at approximately 50 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
RELT (Receptor Expressed in Lymphoid Tissues) is a type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF19-like (TNFRSF19L) (1, 2). It is primarily expressed in hematopoietic tissues and peripheral blood leukocytes. Human RELT cDNA encodes a 430 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide, a 136 aa extracellular domain containing one TNF receptor cysteine-rich domain and one potential N-linked glycosylation site, a 21 aa transmembrane domain and a 247 aa cytoplasmic region containing no death domain. Human RELT shares 85% and 96% aa sequence homology with mouse RELT (Accession # BAC40459) and macaque RELT (Accession # Q9N092), respectively. Among TNFRSF members, the RELT extracellular domain is most closely related to that of TNFRSF19 and OX40. RELT has been shown to exclusively bind the adaptor protein TNF receptor-associated factor 1 (TRAF1). However, it has also been shown to activate the NF-kappa B pathway independently of TRAFs. Immobilized RELT can co‑stimulate T-cell proliferation in the presence of CD3 signaling, suggesting a potential regulatory role in immune response.
- Sica, G. et al. (2001) Blood 97:2702.
Citations for Human RELT/TNFRSF19L Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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RELT stains prominently in B-cell lymphomas and binds the hematopoietic transcription factor MDFIC
Authors: JK Cusick, Y Alhomsy, S Wong, G Talbott, VN Uversky, C Hart, N Hejazi, AT Jacobs, Y Shi
Biochemistry and Biophysics Reports, 2020;24(0):100868.
Sample Types: Whole Tissue
RELT induces cellular death in HEK 293 epithelial cells.
Authors: Cusick JK, Mustian A, Goldberg K, Reyland ME
Cell. Immunol., 2010;261(1):1-8.
Sample Types: Cell Lysates
Applications: Western Blot
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