Human SOX17 Antibody

Catalog # Availability Size / Price Qty
MAB1924
MAB1924-SP
SOX17 in B16 Mouse Cell Line.
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Product Details
Citations (35)
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Reviews (1)

Human SOX17 Antibody Summary

Species Reactivity
Human
Specificity
Detects human SOX17 in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant human SOX2, 3, 7, or 10.
Source
Monoclonal Mouse IgG3 Clone # 245013
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human SOX17
Asp177-Val414
Accession # Q9H6I2
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Immunocytochemistry
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunocytochemistry SOX17 antibody in B16 Mouse Cell Line by Immunocytochemistry (ICC). View Larger

SOX17 in B16 Mouse Cell Line. SOX17 was detected in immersion fixed B16 mouse melanoma cell line using Mouse Anti-Human SOX17 Monoclonal Antibody (Catalog # MAB1924) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (yellow, upper panel; Catalog # NL007) and counterstained with DAPI (blue, lower panel). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SOX17

SOX17 is a member of the SOX family of transcription factors that bind DNA via a high mobility group (HMG) domain. SOX17 is suggested to play an important role in endoderm development (1, 2).

References
  1. Kanai-Azuma, M. et al. (2002) Development 129:2367.
  2. Katoh, M. et al. (2002) Int. J. Mol. Med. 9:153.
Long Name
Transcription Factor SOX17
Entrez Gene IDs
64321 (Human)
Alternate Names
FLJ22252; SOX17; SRY (sex determining region Y)-box 17; SRY-related HMG-box transcription factor SOX17; transcription factor SOX-17; VUR3

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Citations for Human SOX17 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

35 Citations: Showing 1 - 10
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  1. Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions
    Authors: K Morita, A Nakamura, M Machida, T Kawasaki, R Nakanishi, J Ichida, T Iwata, A Umezawa, H Akutsu
    Regenerative Therapy, 2022;21(0):389-397.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  2. Generation of a homozygous knock-in human embryonic stem cell line expressing mEos4b-tagged CTR1
    Authors: YH Chen, PS Huang, MH Wen, M Pan, DF Lee, TY Chen
    Oncogene, 2022;63(0):102845.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  3. Generation of a human induced pluripotent stem cell line (LZUSHi002-A) from a MADD patient with ETFDH mutation
    Authors: Y Li, Y Li, H Liu, L Cheng, H Ma, X Xu, N Zhang
    Stem Cell Research, 2022;64(0):102914.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  4. SOX17 and PAX8 constitute an actionable lineage-survival transcriptional complex in ovarian cancer
    Authors: L Lin, K Shi, S Zhou, MC Cai, C Zhang, Y Sun, J Zang, L Cheng, K Ye, P Ma, P Shen, M Zhang, Y Cheng, C Qi, Y Li, X Yin, Y Zheng, L Tan, G Zhuang, R Zang
    Oncogene, 2022;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  5. Generation of an induced pluripotent stem cell line (FDCHI007-A) derived from a patient with developmental and epileptic encephalopathy Type 31 carrying heterozygous c.545C�>�A mutation in DNM1 gene
    Authors: Y Xu, X Wang, T Qiu, J Wang, Y Wang, B Wu, Y Zhou
    Stem Cell Research, 2022;60(0):102709.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  6. Generation of an integration-free induced pluripotent stem cell line (LZUSHI001-A) from an epileptic patient with DGKG mutation
    Authors: YQ Liu, TW Ling, HY Wang, YH Yang, WJ Song, TC Wang
    Stem Cell Research, 2022;61(0):102768.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  7. Generation of a gene corrected human isogenic iPSC line (CPGHi001-A-1) from a hearing loss patient with the TMC1 p.M418K mutation using CRISPR/Cas9
    Authors: H Wang, Y Luo, J Li, J Guan, S Yang, Q Wang
    Stem Cell Research, 2022;60(0):102736.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  8. An induced pluripotent stem cell line (GZHMCi004-A) derived from a fetus with heterozygous G380R mutation in FGFR3 gene causing achondroplasia
    Authors: N Li, SM Lin, Y Li, J Sun, L Zhang, M Chen
    Stem Cell Research, 2021;53(0):102322.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Generation of a gene-corrected isogenic iPSC line (AHQUi001-A-1) from a patient with familial hypertriglyceridemia (FHTG) carrying a heterozygous p.C310R (c.928�T�>�C) mutation in LPL gene using CRISPR/Cas9
    Authors: X Sun, X Zhou, B Dong, C Wang, X Xiao, Y Wang
    Stem Cell Research, 2021;52(0):102230.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Generation of human induced pluripotent stem cell line, KRIBBi003-A, from urinary cells of a patient with glycogen storage disease type IXa
    Authors: Y Shin, SJ Mun, J Lee, KS Chung, M Kim, C Kun Cheon, MJ Son
    Stem Cell Research, 2021;57(0):102584.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. An induced pluripotent stem cell line (GZHMCi003-A) derived from a fetus with exon 3 heterozygous deletion in RUNX2 gene causing cleidocranial dysplasia
    Authors: M Chen, SM Lin, N Li, Y Li, Y Li, L Zhang
    Stem Cell Research, 2021;51(0):102166.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Generation of insulin-producing pancreatic beta cells from multiple human stem cell lines
    Authors: NJ Hogrebe, KG Maxwell, P Augsornwor, JR Millman
    Nature Protocols, 2021;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  13. Generation of an induced pluripotent stem cell line (FDCHi006-A) from a 7-year-old girl with central precocious puberty
    Authors: T Fan, J He, Y Wang, J Yu, W Sun
    Stem Cell Research, 2021;56(0):102542.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. Generation of an induced pluripotent stem cell line (OGHFUi001-A) from a type 1 early infantile epileptic encephalopathy with ARX mutation
    Authors: N Jia, X Gong, J Chen, T Yang, C Bao, J Shen, X Xiao
    Stem Cell Research, 2021;53(0):102367.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  15. Generation of a human induced pluripotent stem cell line (CPGHi003-A) from an auditory neuropathy patient with AIFM1 p.R422Q mutation
    Authors: J Li, K Wu, J Guan, Q Wang, H Wang
    Stem Cell Research, 2021;53(0):102376.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. Generation of human induced pluripotent stem cell lines from 2 patients with MIRAGE syndrome
    Authors: I Fischer, J Küchler, C Schaar, T Fisch, J Cernoch, K Fischer, V Fernández, P Kühnen, H Stachelsch
    Stem Cell Research, 2021;54(0):102417.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. Generation of an iPSC line (GWCMCi002-A) from an X-linked Alport syndrome patient with a hemizygous splicing mutation (NM_000495.4, c. 1517-1 G�>�T) in the COL4A5 gene
    Authors: X Gao, G Li, H Deng, W Feng, Y Li, M Liu, Y Li
    Stem Cell Research, 2021;53(0):102388.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  18. Generation of a gene corrected human isogenic iPSC line (CPGHi002-A-1) from a DDOD patient with heterozygous c.1516 C>T mutation in the ATP6V1B2 gene
    Authors: X Gao, SW Qiu, WQ Wang, DY Kang, N Su, P Dai, YY Yuan
    Stem Cell Research, 2021;53(0):102271.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  19. Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson's disease carrying the I2020T mutation in LRRK2
    Authors: E Ohta, T Sone, H Ukai, T Hisamatsu, T Kitagawa, M Ishikawa, M Nagai, HR Ueda, F Obata, H Okano
    Stem Cell Res, 2020;49(0):102073.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  20. Generation of an induced pluripotent stem cell line (PUMCHi006-A) derived from a patient with pulmonary arterial hypertension carrying heterozygous c.1339 G�>�A mutation in PTGIS gene
    Authors: YJ Zhu, SJ Zhang, XH Wu, TY Lian, YZ He, ZJ Zhang, D Lu, K Sun, HF Wang, ZC Jing
    Stem Cell Res, 2020;49(0):102088.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  21. Establishment of human induced pluripotent stem cell line (CPGHi002-A) from a 10-month-old female patient with DDOD syndrome carrying a heterozygous c.1516 C�>�T mutation in ATP6V1B2
    Authors: X Gao, SW Qiu, ML Feng, SS Huang, DY Kang, MY Han, P Dai, YY Yuan
    Stem Cell Res, 2020;48(0):101986.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  22. Derivation of an induced pluripotent stem cell line (GWCMCi001-A) from PBMCs of a four-year-old male patient with Immunoglobulin A nephropathy
    Authors: X Gao, X Liao, J Zhang, J Lin, M Tan
    Stem Cell Research, 2020;50(0):102123.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  23. An induced pluripotent stem cell line (SHEHi002-A (5426))from a patient of long QT syndrome type 8 with c.2573G>A mutation in the gene CACNA1C
    Authors: HM Zhou, XQ Zhou, JZ Lu, WW Jia, JH Kang
    Stem Cell Res, 2020;43(0):101731.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  24. The combination of dibenzazepine and a DOT1L inhibitor enables a stable maintenance of human na�ve-state pluripotency in non-hypoxic conditions
    Authors: W Isono, T Kawasaki, JK Ichida, T Ayabe, O Hiraike, A Umezawa, H Akutsu
    Regenerative Therapy, 2020;15(0):161-168.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  25. Generation of an induced pluripotent stem cell line (CHFUi001-A) from an osteogenesis imperfecta patient with COL1A2 mutation
    Authors: Z Zheng, W Lu, Z Pei, J Chen, T Yang, F Luo
    Stem Cell Res, 2020;47(0):101907.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  26. Measles vector as a multiple genes delivery platform facilitating iPSC reprogramming
    Authors: Q Wang, A Vossen, Y Ikeda, P Devaux
    Gene Ther., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  27. Generation of an induced pluripotent stem cell line from a patient with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): HIHCNi003-A
    Authors: SN Hayer, Y Schelling, P Hoeflinger, S Hauser, L Schöls
    Stem Cell Res, 2018;30(0):206-209.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  28. Generation of two human isogenic iPSC lines from fetal dermal fibroblasts
    Authors: R Tandon, B Brändl, N Baryshniko, A Landshamme, L Steenpa beta, O Keminer, O Pless, FJ Müller
    Stem Cell Res, 2018;33(0):120-124.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  29. Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells
    Authors: L Yu, J Li, J Hong, Y Takashima, N Fujimoto, M Nakajima, A Yamamoto, X Dong, Y Dang, Y Hou, W Yang, I Minami, K Okita, M Tanaka, C Luo, F Tang, Y Chen, C Tang, H Kotera, L Liu
    Stem Cell Reports, 2018;11(1):142-156.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  30. PI3K/mTORC2 regulates TGF-beta/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.
    Authors: Yu J, Ramasamy T, Murphy N, Holt M, Czapiewski R, Wei S, Cui W
    Nat Commun, 2015;6(0):7212.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  31. Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells.
    Authors: Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y
    Mol Ther, 2013;21(1):228-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  32. FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells.
    Authors: Sui L, Mfopou J, Geens M, Sermon K, Bouwens L
    Biochem Biophys Res Commun, 2012;426(3):380-5.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  33. New cell lines from mouse epiblast share defining features with human embryonic stem cells.
    Authors: Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD
    Nature, 2007;448(7150):196-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  34. Conditional gene expression in human embryonic stem cells.
    Authors: Vallier L, Alexander M, Pedersen R
    Stem Cells, 2007;25(6):1490-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  35. Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells.
    Authors: Kim BK, Kim SE, Shim JH, Woo DH, Gil JE, Kim SK, Kim JH
    FEBS Lett., 2006;580(25):5869-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC

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Human SOX17 Antibody
By Anonymous on 08/23/2021
Application: ICC/IF Sample Tested: iPS2 human induced pluripotent stem cells Species: Human

It worked well in 1:200 dilution