Mouse DNER Antibody

Catalog # Availability Size / Price Qty
DNER in Mouse Brain.
1 Image
Product Details
Citations (6)
Supplemental Products

Mouse DNER Antibody Summary

Species Reactivity
Detects mouse DNER in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human DNER is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant mouse DNER
Accession # Q8JZM4
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Mouse DNER (Catalog # 2254-DN)
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry DNER antibody in Mouse Brain by Immunohistochemistry (IHC-Fr). View Larger

DNER in Mouse Brain. DNER was detected in perfusion fixed frozen sections of mouse brain (cerebellum) using Goat Anti-Mouse DNER Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2254) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to Purkinje neurons and molecular layer. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: DNER

DNER, also known as BET, is a type I transmembrane glycoprotein that is specifically expressed on nonaxonal areas of post-mitotic neurons. The protein has an extracellular domain containing ten distinct EGF-like repeats similar to those found on Delta and Notch. Human and mouse DNER share 90% amino acid sequence identity.

Long Name
Delta/Notch-like EGF Repeat-containing Transmembrane
Entrez Gene IDs
92737 (Human); 227325 (Mouse)
Alternate Names
bet; delta and Notch-like epidermal growth factor-related receptor; delta/notch-like EGF repeat containing; delta-notch-like EGF repeat-containing transmembrane; DNER; H_NH0150O02.1; UNQ26; WUGSC:H_NH0150O02.1

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Citations for Mouse DNER Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model
    Authors: M Marino, L Zhou, MY Rincon, Z Callaerts-, J Verhaert, J Wahis, E Creemers, L Yshii, K Wierda, T Saito, C Marneffe, I Voytyuk, Y Wouters, M Dewilde, SI Duqué, C Vincke, Y Levites, TE Golde, TC Saido, S Muylderman, A Liston, B De Stroope, MG Holt
    Embo Molecular Medicine, 2022;14(4):e09824.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  2. A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs
    Authors: YT Shue, AP Drainas, NY Li, SM Pearsall, D Morgan, N Sinnott-Ar, SQ Hipkins, GL Coles, JS Lim, AE Oro, KL Simpson, C Dive, J Sage
    Nature Communications, 2022;13(1):2690.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  3. The Notch ligand DNER regulates macrophage IFN? release in chronic obstructive pulmonary disease
    Authors: C Ballester-, TM Conlon, Z Ertüz, FR Greiffo, M Irmler, SE Verleden, J Beckers, IE Fernandez, O Eickelberg, AÖ Yildirim
    EBioMedicine, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  4. DNER modulates the length, polarity and synaptogenesis of spiral ganglion neurons via the Notch signaling pathway
    Authors: J Du, X Wang, X Zhang, X Zhang, H Jiang
    Mol Med Rep, 2018;17(2):2357-2365.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  5. Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand
    PLoS ONE, 2016;11(9):e0161157.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  6. A search for factors specifying tonotopy implicates DNER in hair-cell development in the chick's cochlea.
    Authors: Kowalik L, Hudspeth AJ
    Dev. Biol., 2011;354(2):221-31.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: IHC-Fr


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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Goat IgG (H+L) Antibody


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