Mouse GDF-1 Antibody
Mouse GDF-1 Antibody Summary
Accession # P20863
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Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Growth and Differentiation Factor 1 (GDF‑1) is a secreted protein in the TGF‑ beta superfamily (1). It is the functional equivalent of frog, zebrafish, and chick Vg1 (2, 3). Human GDF‑1 is synthesized as a preproprotein that produces an approximately 44 kDa proprotein after cleavage of a 29 amino acid (aa) signal peptide. Further proteolysis at a dibasic cleavage site produces a 224 aa propeptide and a secreted 119 aa, 12‑15 kDa mature peptide (4). Mature human GDF‑1 shares 81% aa sequence identity with mouse and rat GDF‑1. GDF‑1 is expressed in the developing and adult nervous system, particularly in neurons of the cerebral cortex and hippocampus (4, 5). It is required during embryogenesis for development of left/right axis asymmetry, anterior/posterior axis asymmetry, and the notochord (2, 3, 6, 7). It cooperates with Nodal and GDF‑3 in these activities and potentiates Nodal bioactivity through formation of a 27 kDa noncovalent GDF‑1‑Nodal heterodimer (3, 7, 8). The presence of Nodal is required for GDF‑1 induced effects (8). GDF‑1 signals through heteromeric receptor complexes containing Activin RIIA or Activin RIIB, ALK4 or ALK7, and an EGF‑CFC protein such as Cryptic or Cripto (7‑9). Loss of function mutations in GDF‑1 are associated with a variety of human cardiac development defects (10).
- Rider, C.C. and B. Mulloy (2010) Biochem. J. 429:1.
- Wall, N.A. et al. (2000) Dev. Biol. 227:495.
- Andersson, O. et al. (2007) Dev. Biol. 311:500.
- Lee, S.-J. (1991) Proc. Natl. Acad. Sci. 88:4250.
- Soderstrom, S. and T. Ebendal (1999) J. Neurosci. Res. 56:482.
- Rankin, C.T. et al. (2000) Nat. Genet. 24:262.
- Andersson, O. et al. (2006) Dev. Biol. 293:370.
- Tanaka, C. et al. (2007) Genes Dev. 21:3272.
- Cheng, S.K. et al. (2003) Genes Dev. 17:31.
- Karkera, J.D. et al. (2007) Am. J. Hum. Genet. 81:987.
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