LYVE-1: Products

Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1 (LYVE-1) is a 60-kDa type I transmembrane glycoprotein that is a member of the Link Protein superfamily. HA is found in the extracellular matrix of most animal tissues and in body fluids.

LYVE-1 is expressed on both the lumenal and ablumenal surfaces of lymphatic endothelium, and also on hepatic blood sinusoidal endothelia. This expression pattern, combined with studies showing that LYVE-1 can support cellular HA internalization in vitro, may suggest LYVE-1 participation in HA internalization for degradation, or transport of HA from tissues into the lumen of lymphatic vessels. LYVE-1-directed HA localization to lymphatic surfaces might also affect aspects of the immune response or tumor metastases. HA binding to CD44 can still occur in the presence of LYVE-1 in vitro. Therefore, LYVE-1-directed HA localization to lymphatics could provide a substrate for transmigrating CD44+ leukocytes or tumor cells. In addition to hepatic and lymphatic endothelia, some expression of LYVE-1 has been reported on Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium. Roles for LYVE-1 on these cell and tissue types remain to be determined.

"LYVE-1" has 19 results in Products.
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Mouse LYVE-1 Antibody 

4 Images
B/N, CyTOF-ready, Flow, ICC/IF, IHC, WB

Human LYVE-1 Antibody 

Human LYVE-1 Biotinylated Antibody 


Rat LYVE-1 Antibody 

2 Images

Human LYVE-1 Antibody 


Recombinant Human LYVE-1 Protein, CF 

1 Image
Binding Activity

Human LYVE-1 Antibody 

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