Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human, Rat

Applications

Validated:

Western Blot

Cited:

Western Blot, Immunocytochemistry, Immunoprecipitation, ELISA Detection, ELISA Development

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 73805
View all BMPR-II Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human BMPR-II
Ala26-Ile151
Accession # Q13873

Specificity

Detects human BMPR-II in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross‑react with recombinant human (rh) BMP R-IA or rhBMPR-IB.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human BMPR-II Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human BMPR-II Fc Chimera (Catalog # 811-BR)

Reviewed Applications

Read 2 reviews rated 4 using MAB811 in the following applications:

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: BMPR-II

Like other members of the TGF-beta superfamily, cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the binding to heteromeric complex of type I and type II serine-threonine kinase receptors. Both receptor types are required for the signl transduction. BMP receptor II (BMPR-II) is one of the five mammalian type II receptors (including TGF-beta R-II, ActR-II, ActR-IIB, BMPR-II and MISR-II) for the TGF-beta superfamily ligands. The type II receptors for TGF-beta and activin bind ligands with high affinity by itself. In contrast, BMPR-II binds BMP-2, BMP-4 and BMP-7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor. BMPR-II mRNA is widely expressed in fetal and adult tissues. Human and mouse BMPR-II are highly conserved sharing 97% sequence identity.

References

  1. Rosenzweig, B.L. et al. (1995) Proc. Natl. Acad. Sci. USA 92:7632.
  2. Beppu, H. et al. (1997) Biochem. Biophys. Res. Commun. 235:499.
  3. Kawabata, M. et al. (1998) Cytokine and Growth Factor Reviews 9:49.

Long Name

Bone Morphogenetic Protein Receptor II

Alternate Names

BMPR2, BMPRII

Entrez Gene IDs

659 (Human); 12168 (Mouse)

Gene Symbol

BMPR2

UniProt

Q13873

Additional BMPR-II Products

Product Documents for Human BMPR-II Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human BMPR-II Antibody

For research use only

Related Research Areas

BMP Family
Mesenchymal Stem Cell Markers

Citations for Human BMPR-II Antibody

Customer Reviews for Human BMPR-II Antibody (2)

4 out of 5
2 Customer Ratings
5 Stars
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4 Stars
100%
3 Stars
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1 Stars
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Showing  1 - 2 of 2 reviews Showing All
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  • Human BMPR-II Antibody
    Name: Anonymous
    Application: Immunohistochemistry
    Sample Tested: Adult lung
    Species: Mouse
    Verified Customer | Posted 04/26/2025
    Human BMPR-II Antibody MAB811
    Bio-Techne Response
    This review reflects a new species or application tested on a primary antibody.
  • Name: Anonymous
    Application: Flow Cytometry
    Sample Tested: See PMID 19116903
    Species: Human
    Verified Customer | Posted 02/25/2015

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