Human CEACAM-3/CD66d Antibody
Human CEACAM-3/CD66d Antibody Summary
Accession # P40198
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Carcinoembryonic Antigen-related Cell Adhesion Molecule 3, (CEACAM-3) also known as CD66d and CGM1, is a 35 kDa transmembrane glycoprotein in the CEACAM family of the immunoglobulin superfamily. The extracellular region consists of one Ig-like V-type domain, and the cytoplasmic tail contains one ITAM. CEACAM-3 is upregulated on activated neutrophils and mediates their adhesion to vascular endothelial cells. CEACAM-3 binds the Opa opacity proteins on some Gram negative bacteria, leading to bacterial uptake and neutrophil death. Alternate splicing generates an isoform with a substituted cytoplasmic tail and a potentially secreted isoform that contains a highly charged and Ser/Thr-rich sequence in place of the transmembrane and cytoplasmic regions. Orthologs of human CEACAM-3 have not been identified in other species.
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