Human CMG-2/ANTXR2 Antibody

MAB29401 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB29401-100
MAB29401-SP

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CMG-2/ANTXR2 Antibody Summary

Species Reactivity

Human

Specificity

Detects human CMG-2/ANTXR2 in direct ELISAs.

Source

Monoclonal Mouse IgG₁ Clone # 406510

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Mouse myeloma cell line NS0-derived recombinant human CMG-2/ANTXR2
Ser22-Arg200
Accession # P58335

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

ELISA

This antibody functions as an ELISA capture antibody when paired with Goat Anti-Human CMG‑2/ANTXR2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2940).

This product is intended for assay development on various assay platforms requiring antibody pairs.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Reconstitution Buffer Available

Reconstitution Buffer 1 (PBS)

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CMG-2/ANTXR2

Capillary Morphogenesis Protein 2 (CMG-2) is an anthrax toxin receptor (ATR) family protein that contains a von Willebrand factor type A domain. As a result of alternative splicing, at least four isoforms of secreted or type I membrane proteins exist. CMG-2 is widely expressed in human tissues. It binds selectively to collagen type IV and laminin and is also capable of binding the protective antigen (PA) of Bacillus Anthracis in a divalent cation-dependent manner. Soluble CMG-2 is a potent antitoxin and may be used as a treatment of anthrax. Within the region used as immunogen, human and mouse CMG-2 share 76% amino acid sequence homology.

Long Name

Capillary Morphogenesis Protein 2

Entrez Gene IDs

118429 (Human); 71914 (Mouse)

Alternate Names

anthrax toxin receptor 2; ANTXR2; Capillary morphogenesis gene 2 protein; capillary morphogenesis protein 2; cI-35; CMG2; CMG-2; CMG2MGC111533; CMG-2MGC45856; FLJ31074; ISH; JHF; JHS