Human DPPIV/CD26 Antibody

Catalog # Availability Size / Price Qty
AF1180
AF1180-SP
Detection of Human DPPIV/CD26 by Western Blot.
8 Images
Product Details
Citations (55)
FAQs
Supplemental Products
Reviews (4)

Human DPPIV/CD26 Antibody Summary

Species Reactivity
Human
Specificity
Detects human DPPIV/CD26 in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human DPPIV/CD26 (Catalog # 1180-SE)
Asp34-Pro766
Accession # Q53TN1
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.2 µg/mL
See below
Simple Western
2 µg/mL
See below
Immunohistochemistry
1-15 µg/mL
See below
Immunocytochemistry
1-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human DPPIV/CD26 antibody by Western Blot. View Larger

Detection of Human DPPIV/CD26 by Western Blot. Western blot shows lysate of human peripheral blood mononuclear cells (PBMC). PVDF membrane was probed with 0.2 µg/mL of Goat Anti-Human DPPIV/CD26 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1180) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF109). A specific band was detected for DPPIV/CD26 at approximately 110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Western Blot Detection of Human DPPIV/CD26 antibody by Western Blot. View Larger

Detection of Human DPPIV/CD26 by Western Blot. Western blot shows lysate of LoVo human colorectal adenocarcinoma cell line. PVDF membrane was probed with 0.2 µg/mL of Goat Anti-Human DPPIV/CD26 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1180) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for DPPIV/CD26 at approximately 110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry DPPIV/CD26 antibody in Human PBMCs by Immunocytochemistry (ICC). View Larger

DPPIV/CD26 in Human PBMCs. DPPIV/CD26 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using Goat Anti-Human DPPIV/CD26 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1180) at 1.7 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm and plasma membranes. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Immunohistochemistry DPPIV/CD26 antibody in Human Psoriatic Skin by Immunohistochemistry (IHC-P). View Larger

DPPIV/CD26 in Human Psoriatic Skin. DPPIV/CD26 was detected in immersion fixed paraffin-embedded sections of human psoriatic skin using Goat Anti-Human DPPIV/CD26 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1180) at 1 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to keratinocytes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Simple Western Detection of Human DPPIV/CD26 antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Human DPPIV/CD26 by Simple WesternTM. Simple Western lane view shows lysates of LoVo human colorectal adenocarcinoma cell line, loaded at 0.2 mg/mL. A specific band was detected for DPPIV/CD26 at approximately 168 kDa (as indicated) using 2 µg/mL of Goat Anti-Human DPPIV/CD26 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1180) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Western Blot Detection of Human DPPIV/CD26 by Western Blot View Larger

Detection of Human DPPIV/CD26 by Western Blot Expression of different markers in the eight human colon cancer cell lines analyzed. (A) Western blot analysis of EpCAM, LGR5, CD26, E-cadherin and vimentin expression in total cell extracts from the eight cell lines (20 μg of protein in each line). Data shown are representative of three experiments. (B) E-cadherin and EpCAM expression analysis by immunofluorescence in HT-29 and Caco-2 cells. (C) CD44 and CD26 expression analysis by immunofluorescence in HT-29 and Caco-2 cells. (D) LGR5 expression analysis by immunofluorescence in DLD-1 and Caco-2 cells. Nuclei were stained with DAPI. Scale bars: 50 μm. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/31285270), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human DPPIV/CD26 by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Human DPPIV/CD26 by Immunocytochemistry/ Immunofluorescence Comparison of histone modifier sets between two hepatic cell cultures.(A) Differentiation scheme of hESC towards Hepatocyte-like cells (Hep-like). (B) Hep-like cells were generated from hESC and stained with antibodies specific for DPP4 and albumin. Nuclei were stained with the DNA dye H-33342 (blue). Scale bars: 100 µm. (C) RT-qPCR data from three independent experiments for hepatic (ALB, CYP3A, CYP7A1, DPP4, HNF4, MET) and neuronal (TH, DCX, TUBB3) markers. Relative gene expression was calculated using hESC as a calibrator and a set of three reference genes (HPRT, RPL13A, GAPDH). (D) Transcript levels of epigenetic modifiers were measured by RT-qPCR in human liver (huHep), Hep-like islets (Hep-like) and embryonic stem cells (hESC). Data for huHep and Hep-like are indicated as relative change compared to hESC (as reference cell). For comparative display, a scatter plot was constructed so that differentially expressed genes that show pos. association (between Hep-like and huHep) are found in red fields, and those that differed in the sense of regulation fall into blue fields. Values of >10 were set to 10. For quadrant count ratio analysis (QCR) only expression values >2 or <−2 were included. (E) The data measured in D were plotted as heat map, sorted according to rel. huHep expression levels. Transcripts that were >2-fold higher expressed in tissue than in hESC are marked in red, >2-fold lower expression is marked in blue. The color scale ranges from a fold regulation of −20 (dark blue) to +20 (dark red). Measures of variance and p-values are indicated in the supplemental material, genes not regulated significantly (vs. hESC) are displayed as “n.s.”. Image collected and cropped by CiteAb from the following open publication (https://dx.plos.org/10.1371/journal.pone.0102035), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Human DPPIV/CD26 by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Human DPPIV/CD26 by Immunocytochemistry/ Immunofluorescence Comparison of histone modifier sets between two hepatic cell cultures.(A) Differentiation scheme of hESC towards Hepatocyte-like cells (Hep-like). (B) Hep-like cells were generated from hESC and stained with antibodies specific for DPP4 and albumin. Nuclei were stained with the DNA dye H-33342 (blue). Scale bars: 100 µm. (C) RT-qPCR data from three independent experiments for hepatic (ALB, CYP3A, CYP7A1, DPP4, HNF4, MET) and neuronal (TH, DCX, TUBB3) markers. Relative gene expression was calculated using hESC as a calibrator and a set of three reference genes (HPRT, RPL13A, GAPDH). (D) Transcript levels of epigenetic modifiers were measured by RT-qPCR in human liver (huHep), Hep-like islets (Hep-like) and embryonic stem cells (hESC). Data for huHep and Hep-like are indicated as relative change compared to hESC (as reference cell). For comparative display, a scatter plot was constructed so that differentially expressed genes that show pos. association (between Hep-like and huHep) are found in red fields, and those that differed in the sense of regulation fall into blue fields. Values of >10 were set to 10. For quadrant count ratio analysis (QCR) only expression values >2 or <−2 were included. (E) The data measured in D were plotted as heat map, sorted according to rel. huHep expression levels. Transcripts that were >2-fold higher expressed in tissue than in hESC are marked in red, >2-fold lower expression is marked in blue. The color scale ranges from a fold regulation of −20 (dark blue) to +20 (dark red). Measures of variance and p-values are indicated in the supplemental material, genes not regulated significantly (vs. hESC) are displayed as “n.s.”. Image collected and cropped by CiteAb from the following open publication (https://dx.plos.org/10.1371/journal.pone.0102035), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: DPPIV/CD26

DPPIV/CD26 (EC 3.4.14.5) is a serine exopeptidase that releases Xaa-Pro dipeptides from the N-terminus of oligo- and polypeptides. It is a type II membrane protein consisting of a short cytoplasmic tail, a transmembrane domain, and a long extracellular domain. The extracellular domain contains glycosylation sites, a cysteine-rich region and the catalytic active site (Ser, Asp and His charge relay system). The amino acid sequence of the mouse DPPIV/CD26 extracellular domain is 84% and 91% identical to the human and rat counterparts, respectively. In the native state, DPPIV/CD26 is present as a noncovalently linked homodimer on the cell surface of a variety of cell types. The soluble form is also detectable in human serum and other body fluids, the levels of which may have clinical significance in patients with cancer, liver and kidney diseases, and depression.

DPPIV/CD26 plays an important role in many biological and pathological processes. It functions as T cell-activating molecule (THAM). It serves as a cofactor for entry of HIV in CD4+ cells. It binds adenosine deaminase, the deficiency of which causes severe combined immunodeficiency disease in humans. It cleaves chemokines such as stromal-cell-derived factor 1 alpha and macrophage-derived chemokine. It degrades peptide hormones such as glucagon. It truncates procalcitonin, a marker for systemic bacterial infections with elevated levels detected in patients with thermal injury, sepsis and severe infection, and in children with bacterial meningitis.

Long Name
Dipeptidyl-peptidase IV
Entrez Gene IDs
1803 (Human); 13482 (Mouse); 397492 (Porcine); 102133935 (Cynomolgus Monkey)
Alternate Names
ADABP; ADCP-2; ADCP2DPP IV; Adenosine deaminase complexing protein 2TP103; CD26 antigen; CD26; CD26T-cell activation antigen CD26; dipeptidyl peptidase 4; Dipeptidyl peptidase IV; dipeptidylpeptidase 4; dipeptidyl-peptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP4; DPPIV; EC 3.4.14.5

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Citations for Human DPPIV/CD26 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

55 Citations: Showing 1 - 10
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  1. Novel Antibody-Drug Conjugate with Anti-CD26 Humanized Monoclonal Antibody and Transcription Factor IIH (TFIIH) Inhibitor, Triptolide, Inhibits Tumor Growth via Impairing mRNA Synthesis
    Authors: Hayashi M, Madokoro H, Yamada K et al.
    Cancers (Basel)
  2. Surface expression marker profile in colon cancer cell lines and sphere-derived cells suggests complexity in CD26+ cancer stem cells subsets
    Authors: Vazquez-Iglesias L, Barcia-Castro L, Rodriguez-Quiroga M et al.
    Biol Open
  3. Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease
    Authors: Mayer C, Nehring S, K�cken M et al.
    EMBO reports
  4. A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry
    Authors: Jing Chen, Xinglou Yang, Haorui Si, Qianchun Gong, Tengcheng Que, Jing Li et al.
    Cell
  5. A CRISPR screen in intestinal epithelial cells identifies novel factors for polarity and apical transport
    Authors: KMC Klee, MW Hess, M Lohmüller, S Herzog, K Pfaller, T Müller, GF Vogel, LA Huber
    Elife, 2023-01-20;12(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  6. Mapping prohormone processing by proteases in human enteroendocrine cells using genetically engineered organoid models
    Authors: J Beumer, J Bauzá-Mart, TS Veth, V Geurts, C Boot, H Gilliam-Vi, SS Poulsen, FK Knop, W Wu, H Clevers
    Proceedings of the National Academy of Sciences of the United States of America, 2022-11-07;119(46):e2212057119.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  7. Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization
    Authors: J.J. Patten, Patrick T. Keiser, Deisy Morselli-Gysi, Giulia Menichetti, Hiroyuki Mori, Callie J. Donahue et al.
    iScience
  8. Dipeptidyl peptidase 4 expression is not associated with an activated fibroblast phenotype in idiopathic pulmonary fibrosis
    Authors: Måns Kadefors, Frida Berlin, Marie Wildt, Göran Dellgren, Sara Rolandsson Enes, Anders Aspberg et al.
    Frontiers in Pharmacology
  9. Seminal-Plasma-Mediated Effects on Sperm Performance in Humans
    Authors: T Turunen, M Magris, M Malinen, J Kekäläinen
    Cells, 2022-07-08;11(14):.
    Species: Human
    Sample Types: Seminal Plasma
    Applications: Western Blot
  10. Inter-individual Variation in Receptor Expression Influences MERS-CoV Infection and Immune Responses in Airway Epithelia
    Authors: Kun Li, Christine Wohlford-Lenane, Jennifer A. Bartlett, Paul B. McCray
    Frontiers in Public Health
  11. Dysregulation and activities of ubiquitin specific peptidase 2b in the pathogenesis of hepatocellular carcinoma
    Authors: C Nadolny, X Zhang, Q Chen, SF Hashmi, W Ali, C Hemme, N Ahsan, Y Chen, R Deng
    American journal of cancer research, 2021-10-15;11(10):4746-4767.
    Species: Human
    Sample Types: Cell Lysate
    Applications: Western Blot
  12. A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
    Authors: Joep Beumer, Maarten H. Geurts, Mart M. Lamers, Jens Puschhof, Jingshu Zhang, Jelte van der Vaart et al.
    Nature Communications
  13. Stability of human salivary extracellular vesicles containing dipeptidyl peptidase IV under simulated gastrointestinal tract conditions
    Authors: Y Ogawa, Y Akimoto, M Ikemoto, Y Goto, A Ishikawa, S Ohta, Y Takase, H Kawakami, M Tsujimoto, R Yanoshita
    Biochemistry and Biophysics Reports, 2021-06-03;27(0):101034.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  14. Functional inhibition of cancer stemness-related protein DPP4 rescues tyrosine kinase inhibitor resistance in renal cell carcinoma
    Authors: S Kamada, T Namekawa, K Ikeda, T Suzuki, M Kagawa, H Takeshita, A Yano, K Okamoto, T Ichikawa, K Horie-Inou, S Kawakami, S Inoue
    Oncogene, 2021-05-10;0(0):.
    Species: Human
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  15. Advanced Microscopy for Liver and Gut Ultrastructural Pathology in Patients with MVID and PFIC Caused by MYO5B Mutations
    Authors: Michael W. Hess, Iris M. Krainer, Przemyslaw A. Filipek, Barbara Witting, Karin Gutleben, Ilja Vietor et al.
    Journal of Clinical Medicine
  16. CD26 Identifies a Subpopulation of Fibroblasts that Produce the Majority of Collagen during Wound Healing in Human Skin
    Authors: Christal A. Worthen, Yilei Cui, Jeffrey S. Orringer, Timothy M. Johnson, John J. Voorhees, Gary J. Fisher
    Journal of Investigative Dermatology
  17. Diagnostic significance of apical membranous and cytoplasmic dot-like CD26 expression in encapsulated follicular variant of papillary thyroid carcinoma: a useful marker for capsular invasion
    Authors: S Takagi, M Hirokawa, K Nagashima, M Higuchi, K Kadota, R Ishikawa, M Sato, A Miyauchi, Y Miyake, R Haba
    Endocr. J., 2020-09-02;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  18. Chromatin and transcriptome changes in human myoblasts show spatio-temporal correlations and demonstrate DPP4 inhibition in differentiated myotubes
    Authors: TJ Kolanowski, N Rozwadowsk, A Zimna, M Nowaczyk, M Siatkowski, W ?ab?d?, E Wiland, J Gapi?ski, S Jurga, M Kurpisz
    Sci Rep, 2020-08-31;10(1):14336.
    Species: Human
    Sample Types: Cell Lysates, Tissue Homogenates
    Applications: Western Blot
  19. Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection.
    Authors: Menachery V, Dinnon K, Yount B, McAnarney E, Gralinski L, Hale A, Graham R, Scobey T, Anthony S, Wang L, Graham B, Randell S, Lipkin W, Baric R
    J Virol, 2020-02-14;94(5):.
    Species: Human
    Sample Types: cell culture
  20. Teneligliptin prevents doxorubicin-induced inflammation and apoptosis in H9c2 cells
    Authors: W Peng, D Rao, M Zhang, Y Shi, J Wu, G Nie, Q Xia
    Arch. Biochem. Biophys., 2019-12-24;0(0):108238.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Western Blot
  21. Entry of Scotophilus Bat Coronavirus-512 and Severe Acute Respiratory Syndrome Coronavirus in Human and Multiple Animal Cells
    Authors: YN Chen, HC Hsu, SW Wang, HC Lien, HT Lu, SK Peng
    Pathogens, 2019-11-22;8(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  22. Insights into replicative senescence of human testicular peritubular cells
    Authors: N Schmid, F Flenkentha, JB Stöckl, KG Dietrich, FM Köhn, JU Schwarzer, L Kunz, M Luckner, G Wanner, GJ Arnold, T Fröhlich, A Mayerhofer
    Sci Rep, 2019-10-21;9(1):15052.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  23. Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens
    Authors: R Hatano, T Yamada, H Madokoro, H Otsuka, E Komiya, T Itoh, Y Narita, S Iwata, H Yamazaki, S Matsuoka, NH Dang, K Ohnuma, C Morimoto
    PLoS ONE, 2019-06-13;14(6):e0218330.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  24. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus
    Authors: Naoko Iwata-Yoshikawa, Tadashi Okamura, Yukiko Shimizu, Osamu Kotani, Hironori Sato, Hanako Sekimukai et al.
    Journal of Virology
  25. A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques
    Authors: AS Cockrell, JC Johnson, IN Moore, DX Liu, KW Bock, MG Douglas, RL Graham, J Solomon, L Torzewski, C Bartos, R Hart, RS Baric, RF Johnson
    Sci Rep, 2018-07-16;8(1):10727.
    Species: Primate
    Sample Types: Whole Tissue
    Applications: IHC
  26. Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4
    Authors: AK Haverkamp, A Lehmbecker, I Spitzbarth, W Widagdo, BL Haagmans, J Segalés, J Vergara-Al, A Bensaid, JMA van den Br, ADME Osterhaus, W Baumgärtne
    Sci Rep, 2018-06-27;8(1):9778.
    Species: Camelid
    Sample Types: Whole Cells
    Applications: ICC
  27. Discovery of novel bat coronaviruses in south China that use the same receptor as MERS coronavirus
    Authors: CM Luo, N Wang, XL Yang, HZ Liu, W Zhang, B Li, B Hu, C Peng, QB Geng, GJ Zhu, F Li, ZL Shi
    J. Virol., 2018-06-13;0(0):.
    Species: Bat
    Sample Types: Whole Cells
    Applications: Neutralization
  28. Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells
    Authors: H Chu, CM Chan, X Zhang, Y Wang, S Yuan, J Zhou, RK Au-Yeung, KH Sze, D Yang, H Shuai, Y Hou, C Li, X Zhao, VK Poon, SP Leung, ML Yeung, J Yan, G Lu, DY Jin, GF Gao, JF Chan, KY Yuen
    J. Biol. Chem., 2018-06-10;0(0):.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells, Whole Tissue
    Applications: IHC-P, Neutralization, Western Blot
  29. DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
    Authors: Leen J M Seys, W Widagdo, Fien M Verhamme, Alex Kleinjan, Wim Janssens, Guy F Joos et al.
    Clinical Infectious Diseases
  30. Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein
    Authors: W Li, RJG Hulswit, I Widjaja, VS Raj, R McBride, W Peng, W Widagdo, MA Tortorici, B van Dieren, Y Lang, JWM van Lent, JC Paulson, CAM de Haan, RJ de Groot, FJM van Kuppev, BL Haagmans, BJ Bosch
    Proc. Natl. Acad. Sci. U.S.A., 2017-09-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  31. Elevated CD26 Expression by Skin Fibroblasts Distinguishes a Profibrotic Phenotype Involved in Scar Formation Compared to Gingival Fibroblasts
    Authors: W Mah, G Jiang, D Olver, C Gallant-Be, C Wiebe, DA Hart, L Koivisto, H Larjava, L Häkkinen
    Am. J. Pathol., 2017-06-20;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  32. First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers
    Authors: E Angevin, N Isambert, V Trillet-Le, B You, J Alexandre, G Zalcman, P Vielh, F Farace, F Valleix, T Podoll, Y Kuramochi, I Miyashita, O Hosono, NH Dang, K Ohnuma, T Yamada, Y Kaneko, C Morimoto
    Br. J. Cancer, 2017-03-14;116(9):1126-1134.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  33. A humanized anti-CD26 monoclonal antibody inhibits cell growth of malignant mesothelioma via retarded G2/M cell cycle transition
    Authors: Mutsumi Hayashi, Hiroko Madokoro, Koji Yamada, Hiroko Nishida, Chikao Morimoto, Michiie Sakamoto et al.
    Cancer Cell International
  34. TNF-alpha promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts
    Authors: Dominika Wolczyk, Magdalena Zaremba-Czogalla, Anita Hryniewicz-Jankowska, Renata Tabola, Krzysztof Grabowski, Aleksander F. Sikorski et al.
    Cell Oncol (Dordr)
  35. Mapping the Specific Amino Acid Residues That Make Hamster DPP4 Functional as a Receptor for Middle East Respiratory Syndrome Coronavirus
    Authors: Neeltje van Doremalen, Kerri L. Miazgowicz, Vincent J. Munster
    Journal of Virology
  36. Characterization of dedifferentiating human mature adipocytes from the visceral and subcutaneous fat compartments: fibroblast-activation protein alpha and dipeptidyl peptidase 4 as major components of matrix remodeling.
    Authors: Lessard J, Pelletier M, Biertho L, Biron S, Marceau S, Hould F, Lebel S, Moustarah F, Lescelleur O, Marceau P, Tchernof A
    PLoS ONE, 2015-03-27;10(3):e0122065.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  37. Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes.
    Authors: Ohnuma K, Hatano R, Aune T, Otsuka H, Iwata S, Dang N, Yamada T, Morimoto C
    J Immunol, 2015-03-18;194(8):3697-712.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  38. Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.
    Authors: Peck K, Cockrell A, Yount B, Scobey T, Baric R, Heise M
    J Virol, 2015-02-04;89(8):4696-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  39. High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus.
    Authors: Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M
    J Virol, 2015-01-21;89(7):3859-69.
    Species: Human
    Sample Types: Whole Cells
    Applications: Blocking
  40. Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease.
    Authors: Agrawal A, Garron T, Tao X, Peng B, Wakamiya M, Chan T, Couch R, Tseng C
    J Virol, 2015-01-14;89(7):3659-70.
    Species: Human
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-P, Western Blot
  41. CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory syndrome coronavirus (MERS-CoV) infection and evolution of persistent infection.
    Authors: Cai Y, Yu S, Postnikova E, Mazur S, Bernbaum J, Burk R, Zhang T, Radoshitzky S, Muller M, Jordan I, Bollinger L, Hensley L, Jahrling P, Kuhn J
    PLoS ONE, 2014-11-19;9(11):e112060.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  42. Lineage-specific regulation of epigenetic modifier genes in human liver and brain.
    Authors: Weng, Matthias, Natarajan, Karthick, Scholz, Diana, Ivanova, Violeta, Sachinidis, Agapios, Hengstler, Jan G, Waldmann, Tanja, Leist, Marcel
    PLoS ONE, 2014-07-23;9(7):e102035.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  43. Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma.
    Authors: Yamamoto, J, Ohnuma, K, Hatano, R, Okamoto, T, Komiya, E, Yamazaki, H, Iwata, S, Dang, N H, Aoe, K, Kishimoto, T, Yamada, T, Morimoto, C
    Br J Cancer, 2014-04-17;110(9):2232-45.
    Species: Human
    Sample Types: Cell Fraction, Cell Lysates, Whole Cells, Whole Tissue
    Applications: ICC, IHC, Immunoprecipitation, Western Blot
  44. Prognostic significance of the combined expression of neutral endopeptidase and dipeptidyl peptidase IV in intrahepatic cholangiocarcinoma patients after surgery resection
    Authors: Jianyong Qiu, Jianyong Zhu, XiaoDong Guo, Zhiyan Li, Nianxin Xia, Yingxiang Yang et al.
    OncoTargets and Therapy
  45. In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection.
    Authors: Eckerle I, Muller M, Kallies S, Gotthardt D, Drosten C
    Virol J, 2013-12-23;10(0):359.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  46. Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.
    Authors: Raj, V Stalin, Smits, Saskia L, Provacia, Lisette, van den Brand, Judith M, Wiersma, Lidewij, Ouwendijk, Werner J, Bestebroer, Theo M, Spronken, Monique, van Amerongen, Geert, Rottier, Peter J, Fouchier, Ron A M, Bosch, Berend J, Osterhaus, Albert D, Haagmans, Bart L
    J Virol, 2013-11-20;88(3):1834-8.
    Species: Ferret, Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  47. CD26 expression on T-anaplastic large cell lymphoma (ALCL) line Karpas 299 is associated with increased expression of versican and MT1-MMP and enhanced adhesion.
    Authors: Havre, Pamela A, Dang, Long H, Ohnuma, Kei, Iwata, Satoshi, Morimoto, Chikao, Dang, Nam H
    BMC Cancer, 2013-11-01;13(0):517.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  48. Nuclear Localization of CD26 Induced by a Humanized Monoclonal Antibody Inhibits Tumor Cell Growth by Modulating of POLR2A Transcription
    Authors: Kohji Yamada, Mutsumi Hayashi, Hiroko Madokoro, Hiroko Nishida, Wenlin Du, Kei Ohnuma et al.
    PLoS ONE
  49. Differential Roles of Hath1, MUC2 and P27Kip1 in Relation with Gamma-Secretase Inhibition in Human Colonic Carcinomas: A Translational Study
    Authors: Frédérique Souazé, Chantal Bou-Hanna, Christine Kandel, François Leclair, Julie Devallière, Béatrice Charreau et al.
    PLoS ONE
  50. Dipeptidyl peptidase-IV is a potential molecular biomarker in diabetic kidney disease
    Authors: Ai-li Sun, Jing-ti Deng, Guang-ju Guan, Shi-hong Chen, Yuan-tao Liu, Jing Cheng et al.
    Diabetes and Vascular Disease Research
  51. Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines
    Authors: Masako Abe, Pamela A Havre, Yasuyo Urasaki, Kei Ohnuma, Chikao Morimoto, Long H Dang et al.
    BMC Cancer
  52. Distinct gene expression-defined classes of gastrointestinal stromal tumor.
    Authors: Yamaguchi U, Nakayama R, Honda K, Ichikawa H, Hasegawa T, Shitashige M, Ono M, Shoji A, Sakuma T, Kuwabara H, Shimada Y, Sasako M, Shimoda T, Kawai A, Hirohashi S, Yamada T
    J. Clin. Oncol., 2008-09-01;26(25):4100-8.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  53. Lymphatic-specific expression of dipeptidyl peptidase IV and its dual role in lymphatic endothelial function.
    Authors: Shin JW, Jurisic G, Detmar M
    Exp. Cell Res., 2008-08-03;314(16):3048-56.
    Species: Human
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-Fr, Western Blot
  54. Overexpression of CD26/DPPIV in mesothelioma tissue and mesothelioma cell lines.
    Authors: Amatya VJ, Takeshima Y, Kushitani K et al.
    Oncol Rep.
  55. SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in beta Cells
    Authors: Coate KC, Cha J, Shrestha S et al.
    Int J Mol Sci

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Human DPPIV/CD26 Antibody
By Ali Baity on 01/30/2023
Application: Immunocytochemistry/Immunofluorescence Sample Tested: HMVEC human microvascular endothelial cells Species: Human

Human DPPIV/CD26 Antibody
By Techung Lee on 10/09/2020
Application: WB Sample Tested: HepG2 human hepatocellular carcinoma cell line Species: Human

Serum-starved HepG2 cells were treated with 100 ng/ml phosphoglucose isomerase (PGI) in minimal essential medium for 2 days, following which cells were harvested and analyzed by Western blotting using the CD26 antibody (1000 fold dilution). The study shows that PGI induces the expression of CD26.


Human DPPIV/CD26 Antibody
By Anonymous on 01/21/2020
Application: IHC Sample Tested: Small intestine Species: Human

IHC-paraffin
working dilution: 1ug/mL
with Bond Refine polymer Detection
rabbit anti-goat IgG as a Linker antibody
epitope retrieval: basic (BOND ER2)


Human DPPIV/CD26 Antibody
By Anonymous on 08/11/2016
Application: IP Sample Tested: Heparin Plasma Species: Mouse