Human LXR alpha/NR1H3 Antibody (Clone K8607)

R&D Systems | Catalog # PP-K8607-00

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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Mouse, Rat, Hamster, Primate - Chlorocebus pygerythrus (Vervet Monkey)

Applications

Validated:

Western Blot, Immunoprecipitation, Gel Supershift Assay

Cited:

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # K8607
View all LXR alpha/NR1H3 Primary Antibodies »

Product Specifications

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Human LXR alpha/NR1H3 Antibody (Clone K8607)

Detection of LXR alpha/NR1H3 by Western Blot

Detection of LXR alpha/NR1H3 by Western Blot

YTHDF2 downregulates LXRA and HIVEP2 through m6A-dependent mRNA decay.a Western blotting of LXR alpha and HIVEP2 in GSC11 cells stably transfected with control shRNA or two YTHDF2 shRNAs. b Western blotting of LXR alpha and HIVEP2 in LN229/EGFRvIII tet-on cells cul Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/33420027), licensed under a CC-BY license. Not internally tested by R&D Systems.
Detection of LXR alpha/NR1H3 by Western Blot

Detection of LXR alpha/NR1H3 by Western Blot

LXR alpha and HIVEP2 are functionally essential targets of YTHDF2 in cell proliferation, invasion, cholesterol dysregulation, and tumorigenesis of GBM cells. A Western blotting of YTHDF2, LXR alpha, and HIVEP2 in GSC11 cells stably expressing shCtrl, shYTHDF2, or shYTHDF2 plus shLXRA or/and shHIVEP2. Representative blot of three independent experiments is shown. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/33420027), licensed under a CC-BY license. Not internally tested by R&D Systems.
Detection of LXR alpha/NR1H3 by Western Blot

Detection of LXR alpha/NR1H3 by Western Blot

YTHDF2 downregulates LXRA and HIVEP2 through m6A-dependent mRNA decay. b Western blotting of LXR alpha and HIVEP2 in LN229/EGFRvIII tet-on cells cultured with vehicle or Doxycycline and transfected with control siRNA or two individual YTHDF2 siRNAs Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/33420027), licensed under a CC-BY license. Not internally tested by R&D Systems.

Applications for Human LXR alpha/NR1H3 Antibody (Clone K8607)

Application
Recommended Usage

Gel Supershift Assay

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 1 review rated 5 using PP-K8607-00 in the following applications:

Formulation, Preparation, and Storage

Formulation

A liquid formulation in physiologic saline with 0.1% NaN3.

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: LXR alpha/NR1H3

Liver X Receptors (LXRs) are oxysterol activated nuclear receptors which are involved in the regulation of cholesterol metabolism and bile acids. Two known isoforms, alpha and beta, are differentially expressed. The alpha isoform is predominantly expressed in liver, whereas the beta isoform expression has been shown to be ubiquitous.

LXR antibodies are useful for lipid and cholesterol metabolism studies.

Long Name

Liver X Receptor alpha

Alternate Names

NR1H3, RLD-1

Entrez Gene IDs

10062 (Human)

Gene Symbol

NR1H3

Additional LXR alpha/NR1H3 Products

Product Documents for Human LXR alpha/NR1H3 Antibody (Clone K8607)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human LXR alpha/NR1H3 Antibody (Clone K8607)

For research use only

Citations for Human LXR alpha/NR1H3 Antibody (Clone K8607)

Customer Reviews for Human LXR alpha/NR1H3 Antibody (Clone K8607) (1)

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  • Human LXR alpha/NR1H3 Antibody (Clone K8607)
    Name: Anonymous
    Application: Western Blot
    Sample Tested: Liver tissue
    Species: Human
    Verified Customer | Posted 08/05/2021
    Human LXR alpha/NR1H3 Antibody (Clone K8607) PP-K8607-00

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