Human LXR alpha/NR1H3 Antibody (Clone K8607) Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of LXR alpha/NR1H3 by Western Blot YTHDF2 downregulates LXRA and HIVEP2 through m6A-dependent mRNA decay.a Western blotting of LXR alpha and HIVEP2 in GSC11 cells stably transfected with control shRNA or two YTHDF2 shRNAs. b Western blotting of LXR alpha and HIVEP2 in LN229/EGFRvIII tet-on cells cul Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/33420027), licensed under a CC-BY license. Not internally tested by R&D Systems.
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Detection of LXR alpha/NR1H3 by Western Blot LXR alpha and HIVEP2 are functionally essential targets of YTHDF2 in cell proliferation, invasion, cholesterol dysregulation, and tumorigenesis of GBM cells. A Western blotting of YTHDF2, LXR alpha, and HIVEP2 in GSC11 cells stably expressing shCtrl, shYTHDF2, or shYTHDF2 plus shLXRA or/and shHIVEP2. Representative blot of three independent experiments is shown. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/33420027), licensed under a CC-BY license. Not internally tested by R&D Systems.
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Detection of LXR alpha/NR1H3 by Western Blot YTHDF2 downregulates LXRA and HIVEP2 through m6A-dependent mRNA decay. b Western blotting of LXR alpha and HIVEP2 in LN229/EGFRvIII tet-on cells cultured with vehicle or Doxycycline and transfected with control siRNA or two individual YTHDF2 siRNAs Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/33420027), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
Background: LXR alpha/NR1H3
Product Datasheets
Citations for Human LXR alpha/NR1H3 Antibody (Clone K8607)
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway.
Authors: Dong B, Kan C, Singh A, Liu J
J Lipid Res, 2013-02-20;54(5):1241-54.
Species: Hamster
Sample Types: Tissue Homogenates
Applications: Western Blot -
Delineation of molecular pathways that regulate hepatic PCSK9 and LDL receptor expression during fasting in normolipidemic hamsters
Authors: Minhao Wu, Bin Dong, Aiqin Cao, Hai Li, Jingwen Liu
Atherosclerosis
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Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling.
Authors: Ronis MJ, Chen Y, Badeaux J, Badger TM
J. Nutr., 2009-06-10;139(8):1431-8.
Species: Rat
Sample Types: Cell Lysates
Applications: Western Blot -
Protein kinase C alpha modulates liver X receptor alpha transactivation.
Authors: Delvecchio CJ, Capone JP
J. Endocrinol., 2008-04-01;197(1):121-30.
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Cell Lysates
Applications: Western Blot -
Liver X receptors alpha and beta regulate renin expression in vivo.
Authors: Morello F, de Boer RA, Steffensen KR, Gnecchi M, Chisholm JW, Boomsma F, Anderson LM, Lawn RM, Gustafsson JK, Lopez-Ilasaca M, Pratt RE, Dzau VJ
J. Clin. Invest., 2005-07-01;115(7):1913-22.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P
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