Human Lysine Hydroxylase 2/PLOD2 Antibody
Human Lysine Hydroxylase 2/PLOD2 Antibody Summary
Accession # NP_891988
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Lysine Hydroxylase 2/PLOD2
Lysine Hydroxylase 2 (LH2) also known as PLOD2 (procollagen-lysine, 2 oxoglutarate 5 dioxygenase 2) is a membrane-bound homodimeric enzyme localized to the cisternae of the rough ER. The enzyme catalyzes the hydroxylation of lysine residues in collagen-like peptides, which in turn serves as sites for carbohydrate attachment in collagen. Two alternatively spliced forms have 737 or 758 amino acids (aa). Human LH2 (758 aa form) shares 92.5% aa sequence identity with the appropriate isoform of mouse and rat LH2.
Citations for Human Lysine Hydroxylase 2/PLOD2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Lysyl Hydroxylase 2 Is Secreted By Tumor Cells and Can Modify Collagen in the Extracellular Space
Authors: Jonathan Kurie
J. Biol. Chem., 2016;0(0):.
Sample Types: Whole Tissue
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma.
Authors: Chen, Yulong, Terajima, Masahiko, Yang, Yanan, Sun, Li, Ahn, Young-Ho, Pankova, Daniela, Puperi, Daniel S, Watanabe, Takeshi, Kim, Min P, Blackmon, Shanda H, Rodriguez, Jaime, Liu, Hui, Behrens, Carmen, Wistuba, Ignacio, Minelli, Rosalba, Scott, Kenneth, Sanchez-Adams, Johannah, Guilak, Farshid, Pati, Debanand, Thilaganathan, Nishan, Burns, Alan R, Creighton, Chad J, Martinez, Elisabet, Zal, Tomasz, Grande-Allen, K Jane, Yamauchi, Mitsuo, Kurie, Jonathan
J Clin Invest, 2015;125(3):1147-62.
Sample Types: Whole Tissue
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western blot detection of PLOD2 in MDA-MB-231 transfected with siRNA against PLOD2. We routinely detect PLOD2 around 100KDa,this is likely related to post-translation modifications of PLOD2