Human/Mouse/Rat PTP-MEG2 Antibody

Catalog # Availability Size / Price Qty
MAB2668
MAB2668-SP

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Detection of Human/Mouse/Rat PTP-MEG2 by Western Blot.
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Product Details
Citations (6)
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Human/Mouse/Rat PTP-MEG2 Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Detects human, mouse, and rat PTP-MEG2.
Source
Monoclonal Mouse IgG2B Clone # 291835
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
E. coli-derived recombinant human PTP-MEG2
Glu2-Gln593
Accession # P43378
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human/Mouse/Rat PTP-MEG2 antibody by Western Blot. View Larger

Detection of Human/Mouse/Rat PTP-MEG2 by Western Blot. Western blot shows lysates of Raji human Burkitt's lymphoma cell line, TS1 mouse helper T cell line, CTLL-2 mouse cytotoxic T cell line, and Nb2-11 rat lymphoma cell line. PVDF membrane was probed with 1 µg/mL of Human/Mouse/Rat PTP-MEG2 Monoclonal Antibody (Catalog # MAB2668) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for PTP-MEG2 at approximately 68 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PTP-MEG2

Megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2), also known as PTPN9, contains an N-terminal domain homologous to the yeast retinaldehyde binding domain Sec14p and a C-terminal phosphatase domain. The Sec14p domain targets PTP-MEG2 to the membrane of secretory vesicles, where it promotes vesicle fusion. Elevated levels of membrane-bound PTP-MEG2 activity in erythroid progenitor cells are observed in polycythemia vera and may affect responsiveness to colony stimulating factors.

Long Name
Megakaryocyte Protein Tyrosine Phosphatase 2
Entrez Gene IDs
5780 (Human); 56294 (Mouse); 266611 (Rat)
Alternate Names
EC 3.1.3.48; MEG2; protein tyrosine phosphatase, non-receptor type 9; Protein-tyrosine phosphatase MEG2; PTPase MEG2; PTPase-MEG2; PTPMEG2; PTP-MEG2; PTPN9; tyrosine-protein phosphatase non-receptor type 9

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Citations for Human/Mouse/Rat PTP-MEG2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Ropivacaine inhibits cervical cancer cell growth via suppression of the miR?96/MEG2/pSTAT3 axis
    Authors: X Chen, W Liu, X Guo, S Huang, X Song
    Oncol. Rep., 2020-02-26;43(5):1659-1668.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. MEG2 is regulated by miR-181a-5p and functions as a tumour suppressor gene to suppress the proliferation and migration of gastric cancer cells
    Authors: Z Liu, F Sun, Y Hong, Y Liu, M Fen, K Yin, X Ge, F Wang, X Chen, W Guan
    Mol. Cancer, 2017-07-26;16(1):133.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer
    Sci Rep, 2016-11-18;6(0):37421.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  4. The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A
    Authors: Guangpu Li
    J. Biol. Chem., 2016-09-21;291(46):23895-23905.
    Species: Mouse, Rat
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  5. Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells.
    Authors: Huang X, Gschweng E, Van Handel B
    Blood, 2010-12-16;117(7):2157-65.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis.
    Authors: Hao Q, Wang L, Zhao ZJ, Tang H
    J. Biol. Chem., 2008-11-09;284(2):799-806.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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