Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunocytochemistry, Immunoprecipitation

Cited:

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # HLS56/3
View all OAS2 Primary Antibodies »

Product Specifications

Immunogen

2’,5’-Oligoadenylate Synthetase-2

Specificity

Detects human OAS2.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Human OAS2 Antibody

OAS2 in U266 Human Cell Line.

OAS2 was detected in immersion fixed U266 human myeloma cell line using Mouse Anti-Human OAS2 Monoclonal Antibody (Catalog # MAB1925) at 3 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. Staining was performed using our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Applications for Human OAS2 Antibody

Application
Recommended Usage

Immunocytochemistry

3-25 µg/mL
Sample: Immersion fixed U266 human myeloma cell line

Immunoprecipitation

Hovanessian, A.G. et al. (1987) EMBO J. 6:1273.

Reviewed Applications

Read 1 review rated 5 using MAB1925 in the following applications:

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: OAS2

OAS2, also known as OAS (69 kDa), is one of three related proteins (along with OAS1 and OAS3) that catalyze the conversion of ATP into 2’,5’-linked adenosine oligomers with the general formula pppA(2’,5’A)n where n > 1 (2, 3) These proteins are induced by interferons, activated by double-stranded RNA, and are implicated in anti-viral immunity (1, 4, 5).

References

  1. Hovanessian, A.G. et al. (1987) EMBO J. 6:1273.
  2. Hovanessian, A.G. et al. (1977) Nature 268:537.
  3. Kerr, I.M. and R.E. Brown (1978) Proc. Natl. Acad. Sci. USA 75:256.
  4. Hovanessian, A.G. et al. (1988) J. Biol. Chem. 263:4959.
  5. Marie, I. et al. (1990) J. Interferon Res. 10:571.
  6. Marie, I. et al. (1990) J. Biol. Chem. 265:18601.

Long Name

2’,5’-Oligoadenylate Synthetase-2

Alternate Names

(2-5')oligo(A) synthase 2, (2'-5')oligo(A) synthetase 2, (2-5')oligo(A) synthetase 2, 2'5' oligoadenylate synthetase 2, 2-5A synthase 2, 2-5A synthetase 2, 2'-5'-oligoadenylate synthase 2, 2'-5'-oligoadenylate synthetase 2 (69-71 kD), 2'-5'-oligoadenylate synthetase 2, 69/71kDa, EC 2.7.7, EC 2.7.7.-, MGC78578, p69 OAS / p71 OAS, p69OAS / p71OAS

Entrez Gene IDs

4939 (Human)

Gene Symbol

OAS2

Additional OAS2 Products

Product Documents for Human OAS2 Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human OAS2 Antibody

For research use only

Citations for Human OAS2 Antibody

Customer Reviews for Human OAS2 Antibody (1)

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  • Human OAS2 Antibody
    Name: Anonymous
    Application: Western Blot
    Sample Tested: Fibroblast lysate
    Species: Human
    Verified Customer | Posted 07/12/2021
    Human OAS2 Antibody MAB1925

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