Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Antibody
Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Antibody Summary
Leu165-Ser406
Accession # Q9BY76
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Applications
Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human/Primate Angiopoietin‑like Protein 4/ANGPTL4 by Simple WesternTM. Simple Western lane view shows lysates of Human Diabetic Adipose, loaded at 0.2 mg/mL. A specific band was detected for Angiopoietin‑like Protein 4/ANGPTL4 at approximately 59 kDa (as indicated) using 50 µg/mL of Goat Anti-Human/Primate Angiopoietin‑like Protein 4/ANGPTL4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3485). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Angiopoietin-like Protein 4/ANGPTL4
ANGPTL4, also known as PPAR gamma angiopoietin-related protein (PGAR), hepatic fibrinogen/angiopoietin-related protein (HFARP) and fasting-induced adipose factor (FIAF), is a secreted protein that shares structural homology with angiopoietins. It contains an N-terminal coiled-coil region that mediates covalent homo-oligomerization and a C-terminal fibrinogen-like domain. ANGPTL4 undergoes proteolytic processing and releases the C-terminal domain, which circulates as a monomer. At least 2 additional splice isoforms exist. ANGPTL4 is most highly expressed in adipose tissues. Its expression is up-regulated in endothelial cells and cardiomyocytes during hypoxia. ANGPTL4 is involved in the regulation of lipid and glucose metabolism. It has also been associated with angiogenesis. The amino acid sequence of human ANGPTL4 is 81%, 76% and 81% identical to that of porcine, mouse and canine ANGPTL4, respectively.
Product Datasheets
Citations for Human/Primate Angiopoietin-like Protein 4/ANGPTL4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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ANGPTL4 Regulates Psoriasis via Modulating Hyperproliferation and Inflammation of Keratinocytes
Authors: Y Zuo, L Dai, L Li, Y Huang, X Liu, X Liu, X Duan, S Jiang, GM Deng, H Chen
Frontiers in Pharmacology, 2022;13(0):850967.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1&alpha for Lung Tumorigenesis
Authors: YT Kang, WC Hsu, CC Ou, HC Tai, HT Hsu, KT Yeh, JL Ko
Int J Mol Sci, 2020;21(2):.
Species: Human
Sample Types: Cell Lys
Applications: Western Blot -
Plasma angiopoietin-like 4 is related to phospholipid transfer protein activity in diabetic and non-diabetic subjects: role of enhanced low grade inflammation
Authors: EG Gruppen, S Kersten, RPF Dullaart
Lipids Health Dis, 2018;17(1):60.
Species: Human
Sample Types: Plasma
Applications: ELISA Development (Capture) -
Effect of diet-induced weight loss on angiopoietin-like protein 4 and adipose tissue lipid metabolism in overweight and obese humans
Authors: BW van der Ko, RG Vink, JWE Jocken, NJT Roumans, GH Goossens, ECM Mariman, MA van Baak, EE Blaak
Physiol Rep, 2018;6(13):e13735.
Species: Human
Sample Types: Plasma
Applications: ELISA Development (Capture) -
Regulation of angiopoietin-like 4 and lipoprotein lipase in human adipose tissue
Authors: W Dijk, S Schutte, EO Aarts, IMC Janssen, L Afman, S Kersten
J Clin Lipidol, 2018;0(0):.
Species: Human
Sample Types: Plasma
Applications: ELISA Capture -
Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines
Authors: K Baba, Y Kitajima, S Miyake, J Nakamura, K Wakiyama, H Sato, K Okuyama, H Kitagawa, T Tanaka, M Hiraki, K Yanagihara, H Noshiro
Sci Rep, 2017;7(1):11127.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Buyang Huanwu Tang improves denervation-dependent muscle atrophy by increasing ANGPTL4, and increases NF-?B and MURF1 levels
Authors: L Zhou, Y Huang, H Xie, X Mei
Mol Med Rep, 2017;0(0):.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot -
ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis
Authors: S Izraely, S Ben-Menach, O Sagi-Assif, T Meshel, DM Marzese, S Ohe, I Zubrilov, M Pasmanik-C, DSB Hoon, IP Witz
Oncotarget, 2017;8(44):75778-75796.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor gamma.
Authors: Alex S, Lange K, Amolo T, Grinstead J, Haakonsson A, Szalowska E, Koppen A, Mudde K, Haenen D, Al-Lahham S, Roelofsen H, Houtman R, van der Burg B, Mandrup S, Bonvin A, Kalkhoven E, Muller M, Hooiveld G, Kersten S
Mol Cell Biol, 2013;33(7):1303-16.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development (Detection) -
Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids.
Authors: Kersten S, Lichtenstein L, Steenbergen E, Mudde K, Hendriks HF, Hesselink MK, Schrauwen P, Muller M
Arterioscler. Thromb. Vasc. Biol., 2009;29(6):969-74.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development
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