Human PXR/NR1I2 Antibody

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Product Details
Citations (1)
Supplemental Products

Human PXR/NR1I2 Antibody Summary

Species Reactivity
This antibody specifically recognizes human PXR1 and human PXR2. Not yet tested in other species.
Monoclonal Mouse IgG2A Clone # H4417
Protein A or G purified from hybridoma culture supernatant
Recombinant human PXR/NR1I2
A liquid formulation in physiologic saline with 0.1% NaN3.


Recommended Concentration
Western Blot
This antibody can be used at 1 μg/mL under reducingconditions and 3 μg/mL under non-reducing conditions with the appropriatesecondary reagents to detect human PXR.
Optimal dilutions should be determined by eachlaboratory.
Direct ELISA
This antibody can be used at 2 μg/mL with the appropriatesecondary reagents to detect human PXR.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Reconstitution Calculator

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Preparation and Storage

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
This antibody is stable for greater than six months when stored at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Background: PXR/NR1I2

Pregnane X Receptor (PXR; also known as SXR and NR1I2) is a 50 kDa member of the Nuclear Receptor (NR1) subfamily of the Nuclear Hormone Receptor family. It is a product of the PXR gene that gives rise to two basic isoforms; a 434 amino acid (aa) PXR1 form and 473 aa PXR2 form. PXR2 differs from PXR1 in that PXR2 contains a 39 aa N-terminal extension. Six PXR1 isoforms have been reported (Swiss Protein Accession # 075469). The anti-human PXR antibody recognizes all isoforms except the "B" isoforms which show a deletion of amino acids 1 - 55 (MEVRP...FNVM). PXR forms a heterodimer with Retinoid X Receptor (RXR) and binds pregnanolone.

Long Name
Pregnane X Receptor
Entrez Gene IDs
8856 (Human); 18171 (Mouse)
Alternate Names
BXR; NR1I2; nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group I, member 2; ONR1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR; PAR1; PAR2; Pregnane X receptor; PRR; PXR; PXRPARq; SAR; Steroid and xenobiotic receptor; SXR; SXRBXR

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Citation for Human PXR/NR1I2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells.
    Authors: Ouyang N, Ke S, Eagleton N
    Br. J. Cancer, 2010;102(12):1753-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC


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Isotype Controls

Mouse IgG2A Isotype Control

Secondary Antibodies

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