Human SOX7 Antibody

Catalog # Availability Size / Price Qty
AF2766
AF2766-SP

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Product Details
Citations (17)
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Human SOX7 Antibody Summary

Species Reactivity
Human
Specificity
Detects human SOX7 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human SOX1, -2, -3, -9, -10, and -17 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human SOX7
Ser249-Ala345
Accession # Q9BT81
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human SOX7
Immunohistochemistry
5-15 µg/mL
Immersion fixed paraffin-embedded sections of human breast and lung

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SOX7

SOX7 belongs to the Sox (SRY-like HMG-box gene) family of transcription factors with diverse roles in development. SOX7 has been suggested to play a crucial role in parietal endoderm differentiation. SOX7 is expressed in many embryonic and adult tissues.

Long Name
Transcription Factor SOX7
Entrez Gene IDs
83595 (Human)
Alternate Names
MGC10895; SOX7 transcription factor; SOX7; SRY (sex determining region Y)-box 7; transcription factor SOX-7

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Citations for Human SOX7 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

17 Citations: Showing 1 - 10
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  1. The blood vasculature instructs lymphatic patterning in a SOX7‐dependent manner
    Authors: Ivy K N Chiang, Matthew S Graus, Nils Kirschnick, Tara Davidson, Winnie Luu, Richard Harwood et al.
    The EMBO Journal
  2. Cell surface fluctuations regulate early embryonic lineage sorting
    Authors: Ayaka Yanagida, Elena Corujo-Simon, Christopher K. Revell, Preeti Sahu, Giuliano G. Stirparo, Irene M. Aspalter et al.
    Cell
  3. The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling
    Authors: N Hong, E Zhang, H Xie, L Jin, Q Zhang, Y Lu, AF Chen, Y Yu, B Zhou, S Chen, Y Yu, K Sun
    Cell Death & Disease, 2021-04-12;12(4):393.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  4. Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells
    Authors: J Klomp, J Hyun, J Klomp, K Pajcini, J Rehman, AB Malik
    J. Biol. Chem., 2020-02-18;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. Sox7 negatively regulates prostate‐specific membrane antigen (PSMA) expression through PSMA‐enhancer
    Authors: Wei Peng, Lizheng Guo, Ruoyi Tang, Xiuju Liu, Rui Jin, Jin‐Tang Dong et al.
    The Prostate
  6. A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse
    Authors: Claire S. Simon, Lu Zhang, Tao Wu, Weibin Cai, Nestor Saiz, Sonja Nowotschin et al.
    Biology Open
  7. SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function
    Authors: Yumeng Zhang, Daniel B. Stovall, Meimei Wan, Qiang Zhang, Jeff W. Chou, Dangdang Li et al.
    International Journal of Molecular Sciences
  8. Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality
    Authors: IK Kim, K Kim, E Lee, DS Oh, CS Park, S Park, JM Yang, JH Kim, HS Kim, DT Shima, JH Kim, SH Hong, YH Cho, YH Kim, JB Park, GY Koh, YS Ju, HK Lee, S Lee, I Kim
    J. Exp. Med., 2018-02-14;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC-P
  9. SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development
    Authors: AJ Lilly, A Mazan, DA Scott, G Lacaud, V Kouskoff
    Mech. Dev., 2017-05-31;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  10. Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos
    Sci Rep, 2016-12-19;6(0):39457.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  11. Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac
    Authors: Andrew J. Lilly, Guilherme Costa, Anne Largeot, Muhammad Z. H. Fadlullah, Michael Lie-A-Ling, Georges Lacaud et al.
    Development
  12. Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation
    Authors: Yoshikazu Hirate, Hitomi Suzuki, Miyuri Kawasumi, Hinako M. Takase, Hitomi Igarashi, Philippe Naquet et al.
    Scientific Reports
  13. Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.
    Authors: Zhou Y, Williams J, Smallwood P, Nathans J
    PLoS ONE, 2015-12-02;10(12):e0143650.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  14. Sox7 is regulated by ETV2 during cardiovascular development.
    Authors: Behrens, Ann N, Zierold, Claudia, Shi, Xiaozhon, Ren, Yi, Koyano-Nakagawa, Naoko, Garry, Daniel J, Martin, Cindy M
    Stem Cells Dev, 2014-06-17;23(17):2004-13.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  15. A role for PDGF signaling in expansion of the extra-embryonic endoderm lineage of the mouse blastocyst.
    Authors: Artus J, Panthier JJ, Hadjantonakis AK
    Development, 2010-09-08;137(20):3361-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  16. Differentiation of rat multipotent adult progenitor cells to functional hepatocyte-like cells by mimicking embryonic liver development
    Authors: Philip Roelandt, Pau Sancho-Bru, Karen Pauwelyn, Catherine Verfaillie
    Nature Protocols
  17. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
    Authors: Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H
    Blood, 2007-11-27;111(4):1933-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC

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