Human Synaptopodin Antibody
Human Synaptopodin Antibody Summary
Ser363-Gln490
Accession # Q8N3V7
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Synaptopodin in Human Kidney. Synaptopodin was detected in immersion fixed paraffin-embedded sections of human kidney using Mouse Anti-Human Synaptopodin Monoclonal Antibody (Catalog # MAB8977) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to glomeruli. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
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Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Synaptopodin
Synaptopodin is a 929 amino acid, actin associated protein with restricted expression in brain and kidney. First reported in glomerular podocytes, the protein is also found in postsynaptic densities (PSDs) in a subpopulation of telencephalic neurons where it is thought to participate in synaptic plasticity in dendritic spines. Despite its localization in PSDs, it is not homologous to other PSD proteins. Loss of synaptopodin expression has been demonstrated in Alzheimer’s patients. In glomeruli, synaptopodin localizes to the cytoplasm of podocyte foot processes.
Product Datasheets
Citations for Human Synaptopodin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease
Authors: ZJ Sun, DY Chang, M Chen, MH Zhao
JCI Insight, 2022;7(24):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis
Authors: LY Wang, XJ Sun, M Chen, MH Zhao
J Transl Med, 2019;17(1):197.
Species: Human
Sample Types: Whole Cells
Applications: ICC/IF -
Tyro3 is a podocyte protective factor in glomerular disease
Authors: F Zhong, Z Chen, L Zhang, Y Xie, V Nair, W Ju, M Kretzler, RG Nelson, Z Li, H Chen, Y Wang, A Zhang, K Lee, Z Liu, JC He
JCI Insight, 2018;3(22):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy
Authors: WJ Liu, ZH Li, XC Chen, XL Zhao, Z Zhong, C Yang, HL Wu, N An, WY Li, HF Liu
Sci Rep, 2017;7(1):8643.
Species: Human
Sample Types: Whole Tissue
Applications: IHC
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