TCL1B in Human Lymphoma. TCL1B was detected in immersion fixed paraffin-embedded sections of human lymphoma using Goat Anti-Human TCL1B Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6794) at 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
Sterile PBS to a final concentration of 0.2 mg/mL.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
TCL1B (T cell leukemia protein 1B; also SYN1 and [p15]TML1) is a monomeric,15 kDa (predicted) member of the TCL1 family of proteins. It is expressed in the embryo and syncytiotrophoblast, and interacts with Akt1 and Akt2 kinase, promoting their activation and the subsequent deactivation of proapoptotic molecules. Human TCL1B is 128 amino acids (aa) in length. There is no definitive structural motif that characterizes TCL1B, save for a unique beta -barrel configuration. Full length human TCL1B shares less than 35% aa identity with five orthologous mouse TCL1B isoforms.
T Cell Leukemia Protein 1B
Entrez Gene IDs:
MTCP1-like protein 1; Oncogene TCL1B; Oncogene TCL-1B; SYN-1; Syncytiotrophoblast-specific protein; T-cell leukemia/lymphoma 1B; T-cell leukemia/lymphoma protein 1B; T-cell lymphoma/leukemia 1B; TCL1; TCL1/MTCP1-like protein 1; TCL1B; TML1; TML1TCL1/ MTCP1-like 1
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