Human Tryptase alpha/beta-1 Antibody

Tryptases are trypsin-like serine proteases, and beta  tryptases appear to be the main isoenzymes expressed in mast cells (1). They are stored in secretory granules of mast cells, where they form active tetramers with heparin proteoglycan. Because of the unique arrangement of the active sites in the tetramer, which are facing a narrow central pore, beta  tryptases are resistant to macromolecule protease inhibitors (2). When mast cells are activated, beta  tryptases are released along with other proteins in secretory granules, participating in provoking inflammatory conditions (3). beta  tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic disorders.