VIP R2 in Human Brain. VIP R2 was detected in immersion fixed paraffin-embedded sections of human brain (caudate nucleus) using 25 µg/mL Mouse Anti-Human VIP R2 Monoclonal Antibody (Catalog # MAB5416) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
Reconstitute at 0.5 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: VIP R2
Human VIP R2 (Vasoactive intestinal polypeptide receptor 2) is a 47 kDa (predicted) seven transmembrane receptor that belongs to the G protein coupled receptor 2 family of proteins. In addition to the seven transmembrane regions, the mature chain also contains in its first extracellular region a hormone receptor domain (aa 49‑114), which includes three N-linked glycosylation sites. Human VIP R2 shares 85% aa identity with mouse and rat VIP R2. VIP R2 is expressed predominantly in skeletal muscle and to a lesser extent in the brain, heart, pancreas, and placenta. VIP R2 is coupled to a cAMP mediated signal transduction pathway and binds VIP and pituitary adenylate cyclase activating polypeptide (PACAP).
Vasoactive Intestinal Peptide Receptor 2
Entrez Gene IDs:
7434 (Human); 22355 (Mouse); 29555 (Rat)
FLJ16511; Helodermin-preferring VIP receptor; PACAP type III receptor; PACAPR3; PACAP-R3; PACAP-R-3; Pituitary adenylate cyclase-activating polypeptide type III receptor; vasoactive intestinal peptide receptor 2; vasoactive intestinal polypeptide receptor 2; VIP R2; VIP2R; VIPR2; VIP-R-2; VPAC2; VPCAP2R
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