Mouse Activin RIB/ALK-4 Antibody
Mouse Activin RIB/ALK-4 Antibody Summary
Accession # Q61271
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Activin RIB/ALK-4
Activin RIB, also known as ALK-4, is a glycosylated 58 kDa type I transmembrane receptor that belongs to the superfamily of TGF-beta serine/threonine kinase receptors. Activin RIB associates with Activin RIIB to form a receptor complex for activin and inhibin molecules (1). These ligands bind to Activin RIIB which then associates with, and phosphorylates, the cytoplasmic domain of Activin RIB to initiate signal transduction (2, 3). Mature mouse Activin RIB consists of a 103 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 356 aa cytoplasmic region that includes the kinase domain (4). Within the ECD, mouse Activin RIB shares 93% and 98% aa sequence identity with human and rat Activin RIB, respectively. It shares 23%‑38% aa sequence identity with other mouse type I receptors Activin RIA, BMPR-IA, BMPR-IB, and TGF-beta RI. Activin receptor signaling is modulated by the direct interaction of Activin RIB with cripto or inhibin binding protein (5‑7). Activin RIB is excluded from the signaling complex if Activin RIIB first binds inhibin and betaglycan (8). Activin RIB functions in a wide variety of growth and differentiation processes, including embryonic cell fate and axis determination, cell proliferation, apoptosis, and tumorigenesis (1, 9, 10).
- Chen, Y.-G. et al. (2006) Exp. Biol. Med. 231:534.
- Attisano, L. et al. (1996) Mol. Cell. Biol. 16:1066.
- Tsuchida, K. et al. (1995) Endocrinology 136:5493.
- Ebner, R. et al. (1993) Science 260:1344.
- Chapman, S.C. and T.K. Woodruff (2001) Mol. Endocrinol. 15:668.
- Bianco, C. et al. (2002) Mol. Cell. Biol. 22:2586.
- Gray, P.C. et al. (2003) Proc. Natl. Acad. Sci. 100:5193.
- Lewis, K.A. et al. (2000) Nature 404:411.
- Gu, Z. et al. (1998) Genes Dev. 12:844.
- Chen, Y. et al. (2004) Dev. Biol. 268:280.
Citation for Mouse Activin RIB/ALK-4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Postnatal regulation of germ cells by activin: the establishment of the initial follicle pool.
Authors: Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Cook RW, Kipp JL, Shea LD, Mayo KE, Woodruff TK
Dev. Biol., 2006-06-17;298(1):132-48.
Sample Types: Whole Tissue
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