Mouse CDNF Antibody

Catalog # Availability Size / Price Qty
CDNF in Mouse Brain.
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Product Details
Citations (1)
Supplemental Products

Mouse CDNF Antibody Summary

Species Reactivity
Detects mouse CDNF in direct ELISAs and Western blots. In direct ELISAs, approximately 30% cross-reactivity with recombinant human CDNF is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant mouse CDNF
Accession # Q8CC36
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Mouse CDNF (Catalog # 5187-CD)
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry CDNF antibody in Mouse Brain by Immunohistochemistry (IHC-Fr). View Larger

CDNF in Mouse Brain. CDNF was detected in perfusion fixed frozen sections of mouse brain (medulla) using Goat Anti-Mouse CDNF Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5187) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal cell bodies and processes. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CDNF

CDNF (conserved dopamine neurotrophic factor), also called Armetl1 (arginine-rich, mutated in early stage tumors-like 1), is a 17‑19 kDa secreted protein that shares 52% amino acid (aa) identity with mouse MANF (mesencephalic-astrocyte-derived neurotrophic factor), also called Armet (1). The Armet designation is not preferred, because the proteins as translated are not actually arginine-rich (1). However, both CDNF and MANF have a high proportion of charged residues, a pattern of eight cysteines shown to form intramoleculular disulfide bonds, and a C-terminal endoplasmic reticulum retention signal (shown to function in MANF) (1‑3). The mouse CDNF cDNA encodes a 187 aa protein with a 24 aa signal sequence and a 163 mature sequence (1). Mature mouse CDNF shares 80%, 87%, 83%, and 82% aa identity with human, rat, equine and bovine CDNF, respectively. Although CDNF mRNA and protein are expressed in pre and postnatal mouse brain, they are mostly abundant in adult heart, skeletal muscle and testis. Transcripts within the postnatal mouse brain are concentrated in the hippocampus, thalamus, corpus callosum and optic nerve (1). Like MANF and GDNF, CDNF promotes survival of dopaminergic neurons in vitro (1, 4). In a rat Parkinson's disease model, CDNF also promotes rescue and restoration of dopaminergic neurons in vivo (1).


  1. Lindholm, P. et al. (2007) Nature 448:73.
  2. Mizobuchi, N. et al. (2007) Cell Struct. Funct. 32:41.
  3. Raykhel, I. et al. (2007) J. Cell Biol. 179:1193.
  4. Petrova, P. et al. (2003) J. Mol. Neurosci. 20:173.
Long Name
Conserved Dopamine Neurotrophic Factor
Entrez Gene IDs
441549 (Human); 227526 (Mouse); 361276 (Rat)
Alternate Names
arginine-rich, mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; CDNF; cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor

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Citation for Mouse CDNF Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival
    Authors: A Eesmaa, LY Yu, H Göös, T Danilova, K Nõges, E Pakarinen, M Varjosalo, M Lindahl, P Lindholm, M Saarma
    International Journal of Molecular Sciences, 2022;23(16):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA Capture


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