Rat μ Opioid R/OPRM1 Antibody

Catalog # Availability Size / Price Qty
MAB6866
MAB6866-SP
Detection of Rat μ Opioid R/OPRM1 by Western Blot.
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Rat μ Opioid R/OPRM1 Antibody Summary

Species Reactivity
Rat
Specificity
Detects rat μ Opioid R/OPRM1 in direct ELISAs.
Source
Monoclonal Mouse IgG2A Clone # 677014
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Synthetic peptide corresponding to His385-Pro398 of rat μ Opioid R/OPRM1
Accession # P33535
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Western Blot Detection of Rat μ Opioid R/OPRM1 by Western Blot. View Larger

Detection of Rat μ Opioid R/OPRM1 by Western Blot.

Western blot shows lysates of rat brain tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human μ Opioid R/
OPRM1 Monoclonal Antibody (Catalog # MAB6866) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for μ Opioid R/OPRM1 at approximately 63 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Sterile PBS to a final concentration of 0.5 mg/mL.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: mu Opioid R/OPRM1

The mu-type opioid receptor (MOR), also known as OPRM1, is a 60‑70 kDa variably glycosylated G protein-coupled receptor that mediates the biological effects of many alkaloid and peptide opioids including morphine. MOR is primarily expressed on neurons in the brain, spinal cord, and gastrointestinal tract as well as on immune cells. MOR activation induces analgesia, euphoria, sedation, respiratory depression, and reduced intestinal motility. Following agonist binding, MOR is phosphorylated and internalized which contributes to opioid tolerance and desensitization. OPRM1 can form heterdimers with several other 7TM GPCRs including the delta-type Opioid Receptor (DOR), Nociceptin/Orphanin Receptor (ORL1), Neurokinin 1 Receptor (NK1), Somatostatin Receptor 2 (SSTR2), Cannabinoid Receptor 1, CCR5, and the alpha 2A-Adrenergic Receptor (ADRA2A). Rat MOR shares 94% and 98% aa sequence identity with human and mouse MOR, respectively.

Long Name
mu Opioid Receptor
Entrez Gene IDs
4988 (Human); 18390 (Mouse); 25601 (Rat)
Alternate Names
hMOP; KIAA0403; LMOR; MOP; mOpioidR; MOR; MOR1; M-OR-1; MOR-1; MOR1MOR; Mu opiate receptor; mu Opioid R; Mu opioid receptor; mu-type opioid receptor; opioid receptor, mu 1; OPRM; OPRM1

Product Datasheets

FAQs

No product specific FAQs exist for this product, however you may

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Isotype Controls

Mouse IgG2A Isotype Control

Ctrl

Reconstitution Buffers

Secondary Antibodies

Mouse IgG2A Antibody

Mouse IgG2A Antibody

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