Recombinant Human KGF/FGF-7 Protein

GMP Version Available: 251-GMP
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Carrier Free

Catalog # Availability Size / Price Qty
251-KG-010/CF
251-KG-050/CF
251-KG-01M/CF

With Carrier

Catalog # Availability Size / Price Qty
251-KG-010
251-KG-050
251-KG-01M
Recombinant Human KGF/FGF-7 Protein Bioactivity
1 Image
Product Details
Citations (57)
FAQs
Reviews (1)

Recombinant Human KGF/FGF-7 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using 4MBr‑5 rhesus monkey epithelial cells. Rubin, J.S. et al. (1989) Proc. Natl. Acad. Sci. USA 86:802. The ED50 for this effect is typically 6-60 ng/mL.
The specific activity of recombinant human KGF/FGF-7 is approximately 1.3 x 103 U/μg, which is calibrated against recombinant human KGF/FGF-7 WHO Standard (NIBSC code: 03/150).   Specific activity is for reference purposes only and is not routinely tested.  
Source
E. coli-derived human KGF/FGF-7 protein
Cys32-Thr194, with an N-terminal Met
Accession #
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
19 kDa

Product Datasheets

251-KG (with carrier)

251-KG/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

251-KG

Formulation Lyophilized from a 0.2 μm filtered solution in MOPS, Na2SO4 and EDTA with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

251-KG/CF

Formulation Lyophilized from a 0.2 μm filtered solution in MOPS, Na2SO4 and EDTA.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Data Image

Bioactivity Recombinant Human KGF/FGF-7 Protein Bioactivity View Larger

Recombinant Human KGF/FGF-7 (Catalog # 251-KG) stimulates cell proliferation of 4MBr-5 rhesus monkey epithelial cells. The ED50 for this effect is 6-60 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: KGF/FGF-7

KGF (keratinocyte growth factor), also known as FGF-7 (fibroblast growth factor-7), is one of 22 known members of the mouse FGF family of secreted proteins that plays a key role in development, morphogenesis, angiogenesis, wound healing, and tumorigenesis (1-4). KGF expression is restricted to cells of mesenchymal origin. When secreted, it acts as a paracrine growth factor for nearby epithelial cells (1). KGF speeds wound healing by being dramatically upregulated in response to damage to skin or internal structures that results in high local concentrations of inflammatory mediators such as IL-1 and TNF-alpha. (2, 5). KGF promotes cell migration and invasion, and mediates melanocyte transfer to keratinocytes upon UVB radiation (6, 7). It has been used ectopically to avoid chemotherapy-induced oral mucositis in patients with hematological malignancies (1). Deletion of KGF affects kidney development, producing abnormally small ureteric buds and fewer nephrons (8). It also impedes hair follicle differentiation (9). The 194 amino acid (aa) KGF precursor contains a 31 aa signal sequence and, like all other FGFs, an ~120 aa beta -trefoil scaffold that includes receptor- and heparin-binding sites. KGF signals only through the IIIb splice form of the tyrosine kinase receptor, FGF R2 (FGF R2-IIIb/KGF R) (10). Receptor dimerization requires an octameric or larger heparin or heparin sulfate proteoglycan (11). FGF-10, also called KGF2, shares 51% aa identity and similar function to KGF, but shows more limited expression than KGF and uses an additional receptor, FGF R2-IIIc (12). Following receptor engagement, KGF is typically degraded, while FGF-10 is recycled (12). Mature human KGF, which is active across species, shares 98% aa sequence identity with bovine, equine, ovine and canine, 96% with mouse and porcine, and 92% with rat KGF, respectively.

References
  1. Finch, P.W. and J.S. Rubin (2006) J. Natl. Cancer Inst. 98:812.
  2. Werner, S. et al. (2007) J. Invest. Dermatol. 127:998.
  3. Werner, S. (1998) Cytokine Growth Factor Rev. 9:153.
  4. Mason, I.J. et al. (1994) Mech. Dev. 45:15.
  5. Geer, D.J. et al. (2005) Am. J. Pathol. 167:1575.
  6. Niu, J. et al. (2007) J. Biol. Chem. 282:6001.
  7. Cardinali, G. et al. (2005) J. Invest. Dermatol. 125:1190.
  8. Qiao, J. et al. (1999) Development 126:547.
  9. Guo, L. et al. (1996) Genes Dev. 10:165.
  10. de Georgi, V. et al. (2007) Dermatol. Clin. 25:477.
  11. Hsu, Y-R. et al. (1999) Biochemistry 38:2523.
  12. Belleudi, F. et al. (2007) Traffic 8:1854.
Long Name
Keratinocyte Growth Factor
Entrez Gene IDs
2252 (Human); 403915 (Canine)
Alternate Names
FGF7; FGF-7; fibroblast growth factor 7HBGF-7; HBGF7; HBGF-7; Heparin-binding growth factor 7; keratinocyte growth factor; KGF; KGFfibroblast growth factor 7 (keratinocyte growth factor)

Citations for Recombinant Human KGF/FGF-7 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

57 Citations: Showing 1 - 10
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  1. The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D
    Authors: AL Rodrigues, HY Liu, YW Chen, M Porotto, A Moscona, HW Snoeck
    Nature Protocols, 2021;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha
    Authors: KA Ludwik, ZM Sandusky, KM Stauffer, Y Li, KL Boyd, GA O'Doherty, TP Stricker, DA Lannigan
    Cell Rep, 2020;32(3):107931.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells
    Authors: AFM Dost, AL Moye, M Vedaie, LM Tran, E Fung, D Heinze, C Villacorta, J Huang, R Hekman, JH Kwan, BC Blum, SM Louie, SP Rowbotham, J Sainz de A, ME Piper, PJ Bhetariya, RT Bronson, A Emili, G Mostoslavs, GA Fishbein, WD Wallace, K Krysan, SM Dubinett, J Yanagawa, DN Kotton, CF Kim
    Cell Stem Cell, 2020;27(4):663-678.e8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
    Authors: J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Lindstrom-, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton
    Cell Stem Cell, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
    Authors: J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton
    bioRxiv, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Heat-Not-Burn cigarette induces oxidative stress response in primary rat alveolar epithelial cells
    Authors: Y Ito, K Oshinden, N Kutsuzawa, C Kohno, S Isaki, K Yokoyama, T Sato, M Tanaka, K Asano
    PLoS ONE, 2020;15(11):e0242789.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  7. A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets
    Authors: M Liu, Q Yan, Y Sun, Y Nam, L Hu, JH Loong, Q Ouyang, Y Zhang, HL Li, FE Kong, L Li, Y Li, MM Li, W Cheng, LX Jiang, S Fang, XD Yang, JQ Mo, YF Gong, YQ Tang, Y Li, YF Yuan, NF Ma, G Lin, S Ma, JG Wang, XY Guan
    Proc. Natl. Acad. Sci. U.S.A., 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  8. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
    Authors: NK Vinckier, NA Patel, RJ Geusz, A Wang, J Wang, I Matta, AR Harrington, M Wortham, N Wetton, J Wang, US Jhala, MG Rosenfeld, CW Benner, HP Shih, M Sander
    Nat Commun, 2020;11(1):2082.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Antagonism of interferon signaling by fibroblast growth factors promotes viral replication
    Authors: L Maddaluno, C Urwyler, T Rauschendo, M Meyer, D Stefanova, R Spörri, M Wietecha, L Ferrarese, D Stoycheva, D Bender, N Li, G Strittmatt, K Nasirujjam, HD Beer, P Staeheli, E Hildt, A Oxenius, S Werner
    EMBO Mol Med, 2020;0(0):e11793.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Generation of lung organoids from human pluripotent stem cells in vitro
    Authors: AJ Miller, BR Dye, D Ferrer-Tor, DR Hill, AW Overeem, LD Shea, JR Spence
    Nat Protoc, 2019;14(2):518-540.
    Species: Human
    Sample Types: Spheroids
    Applications: Bioassay
  11. Point mutations in the PDX1 transactivation domain impair human ?-cell development and function
    Authors: X Wang, M Sterr, Ansarullah, I Burtscher, A Böttcher, J Beckenbaue, J Siehler, T Meitinger, HU Häring, H Staiger, FM Cernilogar, G Schotta, M Irmler, J Beckers, CVE Wright, M Bakhti, H Lickert
    Mol Metab, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
  12. FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation
    Authors: K Lee, H Cho, RW Rickert, QV Li, J Pulecio, CS Leslie, D Huangfu
    Cell Rep, 2019;28(2):382-393.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF- β2 suppression
    Authors: S Fujimoto, R Hayashi, S Hara, Y Sasamoto, J Harrington, M Tsujikawa, K Nishida
    Regen Ther, 2019;11(0):249-257.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells
    Authors: LS Beier, J Rossa, S Woodhouse, S Bergmann, HB Kramer, J Protze, M Eichner, A Piontek, S Vidal-Y-Sy, JM Brandner, G Krause, N Zitzmann, J Piontek
    Int J Mol Sci, 2019;20(19):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells
    Authors: A Jacob, M Vedaie, DA Roberts, DC Thomas, C Villacorta, KD Alysandrat, F Hawkins, DN Kotton
    Nat Protoc, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
    Authors: V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault
    Nat Commun, 2019;10(1):4161.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos
    Authors: L Liu, L Leng, C Liu, C Lu, Y Yuan, L Wu, F Gong, S Zhang, X Wei, M Wang, L Zhao, L Hu, J Wang, H Yang, S Zhu, F Chen, G Lu, Z Shang, G Lin
    Nat Commun, 2019;10(1):364.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Generation of a human embryonic stem cell line expressing tetrameric Zoanthus sp. green fluorescent protein: NERCe002-A-1
    Authors: X Duan, M Xie, Y Peng, L Hu, J Yu, S Zeng, Y Wang, G Lu, G Lin, Y Sun
    Stem Cell Res, 2018;28(0):6-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC
    Authors: J Li, X Wu, Y Zhou, M Lee, L Guo, W Han, W Mo, WM Cao, D Sun, R Xie, Y Huang
    Nucleic Acids Res., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA
    Authors: MA Scavuzzo, J Chmielowie, D Yang, K Wamble, LS Chaboub, L Duraine, B Tepe, SM Glasgow, BR Arenkiel, C Brou, B Deneen, M Borowiak
    Cell Rep, 2018;25(13):3811-3827.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling
    Authors: Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que
    Cell Stem Cell, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation
    Authors: JP Ng-Blichfe, A Schrik, RK Kortekaas, JA Noordhoek, IH Heijink, PS Hiemstra, J Stolk, M Königshoff, R Gosens
    EBioMedicine, 2018;36(0):461-474.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  23. Genome-wide analysis of PDX1 target genes in human pancreatic progenitors
    Authors: X Wang, M Sterr, I Burtscher, S Chen, A Hieronimus, F Machicao, H Staiger, HU Häring, G Lederer, T Meitinger, FM Cernilogar, G Schotta, M Irmler, J Beckers, M Hrab? de A, M Ray, CVE Wright, M Bakhti, H Lickert
    Mol Metab, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells
    Authors: Y Ito, R Al Mubarak, N Roberts, K Correll, W Janssen, J Finigan, R Mishra, HW Chu
    PLoS ONE, 2018;13(4):e0196256.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Voltage-dependent Ca2+ channels promote branching morphogenesis of salivary glands by patterning differential growth
    Authors: JM Kim, S Choi, SW Lee, K Park
    Sci Rep, 2018;8(1):7566.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  26. Beta-Catenin maintains lung epithelial progenitors after lung specification
    Authors: EJ Ostrin, DR Little, KN Gerner-Mau, EA Sumner, R Ríos-Corzo, E Ambrosio, SE Holt, NR Forcioli-C, H Akiyama, SM Hanash, S Kimura, SXL Huang, J Chen
    Development, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells
    Authors: A Kimura, T Toyoda, Y Nishi, M Nasu, A Ohta, K Osafune
    Stem Cell Res, 2017;24(0):61-68.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Radioprotective effects of Keratinocyte Growth Factor-1 against irradiation-induced salivary gland hypofunction
    Authors: JS Choi, HS Shin, HY An, YM Kim, JY Lim
    Oncotarget, 2017;8(8):13496-13508.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. High-resolution promoter map of human limbal epithelial cells cultured with keratinocyte growth factor and rho kinase inhibitor
    Authors: M Yoshihara, Y Sasamoto, R Hayashi, Y Ishikawa, M Tsujikawa, Y Hayashizak, M Itoh, H Kawaji, K Nishida
    Sci Rep, 2017;7(1):2845.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling
    Authors: KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Functional vascularized lung grafts for lung bioengineering
    Authors: NV Dorrello, BA Guenthart, JD O'Neill, J Kim, K Cunningham, YW Chen, M Biscotti, T Swayne, HM Wobma, SXL Huang, HW Snoeck, M Bacchetta, G Vunjak-Nov
    Sci Adv, 2017;3(8):e1700521.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors
    Authors: NAJ Krentz, D van Hoof, Z Li, A Watanabe, M Tang, C Nian, MS German, FC Lynn
    Dev. Cell, 2017;41(2):129-142.e6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Ex vivo analysis of the contribution of FGF10(+) cells to airway smooth muscle cell formation during early lung development
    Authors: E El Agha, V Kheirollah, A Moiseenko, W Seeger, S Bellusci
    Dev. Dyn., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord Wharton's jelly mesenchymal stem cells
    Stem Cell Res Ther, 2016;7(1):165.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Hyaluronan Does Not Regulate Human Epidermal Keratinocyte Proliferation and Differentiation
    Authors: J Malaisse, V Pendaries, F Hontoir, V De Glas, D Van Vlaend, M Simon, C Lambert de, Y Poumay, B Flamion
    J. Biol. Chem, 2016;291(12):6347-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.
    Authors: Wong, Amy P, Chin, Stephani, Xia, Sunny, Garner, Jodi, Bear, Christin, Rossant, Janet
    Nat Protoc, 2015;10(3):363-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Unliganded fibroblast growth factor receptor 1 forms density-independent dimers.
    Authors: Comps-Agrar L, Dunshee D, Eaton D, Sonoda J
    J Biol Chem, 2015;290(40):24166-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.
    Authors: Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor A, Yasuda Y, Niki T
    BMC Cancer, 2015;15(0):82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H
    Nat Protoc, 2015;10(3):413-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang, Sarah X, Islam, Mohammad, O'Neill, John, Hu, Zheng, Yang, Yong-Gua, Chen, Ya-Wen, Mumau, Melanie, Green, Michael, Vunjak-Novakovic, Gordana, Bhattacharya, Jahar, Snoeck, Hans-Wil
    Nat Biotechnol, 2014;32(1):84-91.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  41. Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10.
    Authors: Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, Tamada T, Sugiura H, Harigae H, Ichinose M
    Mol Cell Biol, 2014;34(15):2848-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
    Authors: Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J
    J Am Soc Nephrol, 2014;25(6):1211-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. A stimulation-dependent alternate core promoter links lymphotoxin alpha expression with TGF-beta1 and fibroblast growth factor-7 signaling in primary human T cells.
    Authors: Yokley B, Selby S, Posch P
    J Immunol, 2013;190(9):4573-84.
  44. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman D, Phung C, Kumar N, Willert K
    Cell Death Differ, 2013;20(3):369-81.
  45. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells.
    Authors: Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L
    Cell Transplant, 2012;21(6):1321-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  46. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
    Authors: Tomlinson DC, Knowles MA
    Am. J. Pathol., 2010;177(5):2379-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression.
    Authors: Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S
    J. Biol. Chem., 2008;283(34):23139-49.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  48. Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation.
    Authors: Patel VN, Likar KM, Zisman-Rozen S, Cowherd SN, Lassiter KS, Sher I, Yates EA, Turnbull JE, Ron D, Hoffman MP
    J. Biol. Chem., 2008;283(14):9308-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.
    Authors: Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP
    Development, 2007;134(23):4177-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
    Authors: Sa SM, Valdez PA, Wu J
    J. Immunol., 2007;178(4):2229-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways.
    Authors: Li F, Shetty AK, Sugahara K
    J. Biol. Chem., 2007;282(5):2956-66.
    Species: Fish - Prionace glauca (Blue Shark)
    Sample Types: Peptide
    Applications: Bioassay
  52. Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro.
    Authors: Wang J, Edeen K, Manzer R, Chang Y, Wang S, Chen X, Funk CJ, Cosgrove GP, Fang X, Mason RJ
    Am. J. Respir. Cell Mol. Biol., 2007;36(6):661-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression.
    Authors: Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L
    J. Endocrinol., 2006;191(1):65-81.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Bioassay
  54. FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc.
    Authors: Nakayama T, Mutsuga N, Tosato G
    Blood, 2006;109(4):1363-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis.
    Authors: Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP
    Development, 2005;132(6):1223-34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition.
    Authors: Witte RP, Kao WJ
    Biomaterials, 2005;26(17):3673-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.
    Authors: Beer HD, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, Werner S
    Oncogene, 2005;24(34):5269-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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Recombinant Human KGF/FGF-7 Protein
By Anonymous on 01/02/2021
Application: Cell Culture