Regenerative Medicine
Accelerate process development and scale to clinic. Discover stem cell culture and analysis solutions for your workflow.
Regenerative medicine is an innovative field focused on repairing, replacing, or regenerating damaged tissues and organs through stem cell-based therapies. As demand for effective and scalable regenerative treatments increases, developers face complex challenges-including optimizing stem cell culture conditions, ensuring reproducibility, and reliably characterizing therapeutic products.
R&D Systems empowers scientists and manufacturers with comprehensive solutions for every step of the regenerative medicine workflow. Our portfolio includes high-quality recombinant cytokines and growth factors, small molecules, extracellular matrices, culture media and supplements, and advanced single cell sorting/dispenser platforms for robust stem cell expansion and differentiation. To streamline therapy characterization, we offer validated antibodies, ELISA kits, and automated protein analysis platforms designed to deliver consistent, reliable results.
From phase-appropriate reagents to flexible analytical instrumentation, we provide the tools and expertise you need to advance safe, effective, and scalable therapies, while maintaining compliance, continuity, and confidence at every workflow stage
Regenerative Medicine Workflow
Reprogramming readily accessible somatic cell types to generate induced pluripotent stem cells (iPSCs) has unlocked new possibilities in regenerative medicine. However, challenges like reprogramming efficiency, mutation risk, and exogenous gene reintroduction can hinder translation to clinical applications. Enhance your efficiency, cell viability, and throughput using our innovative solutions.
Featured Solutions
Regulatory Compliant Reprogramming Solutions
Small molecules, used as ancillary materials in the generation of stem cell therapies, are required to be safe and reliable to ensure the safety of the therapeutic. Our GMP products are manufactured in compliance with ISO 9001 certification, USP and European guidelines, guaranteeing quality-assured materials you can trust.
Unravel the Stem Cell Signaling Web
Monitor and quantify changes in intracellular signaling pathways during reprogramming with Simple Western systems. Experience unrivalled multiplex flexibility, sensitivity, and reproducibility in measuring protein expression, with analysis that scales from research to manufacturing workflows.
Efficient Verification for Reliable Results
Reduce variation and improve consistency between studies by confirming a healthy starting cell population with our PSC Functional Identification Kit. Generate results in just five days, saving time and reagents.
View PSC Functional Identification Kit
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Engineering novel cells has never been easier - from efficient large DNA payload delivery to automated single cell isolation and analysis. We've developed an integrated suite of solutions that not only save your precious time but also pave the way for effortless scalability.
Featured Solutions
Simplified Cell Engineering
Rapidly generate transgenic cells from proof-of-concept studies to large-scale applications with TcBuster™, a cutting-edge transposon-based gene delivery platform. With its high editing efficiency and large cargo capacity, TcBuster offers unparalleled flexibility and ease of use in cell engineering, especially for iPSCs.
Characterization Made Easy
Ensure optimal clonality with Namocell Single Single Cell Dispensers. Their exceptional efficiency and consistency in isolating individual cells makes single cell cloning simple and fast, enabling full characterization of desired clone phenotypes and genotypes.
Discover Namocell Single Cell Dispensers
Streamline Protein Expression Quantification
Simple Western systems streamline protein expression quantification post-cell engineering. Offering precise measurements, these automated capillary-based immunoassays enable simultaneous detection of total proteins without the need for housekeeping proteins, in sample sizes as low as 3 μL.
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Regenerative medicine therapies require a significant quantity of high-quality stem cells, making large-scale expansion a critical step in development. Success at this stage hinges on three crucial factors: scalability, consistency, and preservation of differentiation potential. Achieving all three demands cell culture conditions that are not only optimized and consistent, but also precisely tailored to efficiently expand stem cell populations while preserving essential characteristics following differentiation.
Featured Solutions
Animal-Free PSC Culturing
Achieve robust expansion and consistent maintenance of pluripotent stem cell cultures with ExCellerate™ iPSC Expansion Media. Compatible with various matrices and cell lines, it sustains cell viability, genotype, and differentiation potential. Free of animal components and available in both RUO and GMP formulations, it offers optimized buffering for reliable and reproducible results.
Discover ExCellerate iPSC Expansion Media
Animal-Free RUO and GMP Proteins
Cytokines and other growth factors play an essential role in cell expansion, health and function. Enhance the safety, bioactivity, and consistency of your stem cell cultures by harnessing high-quality, animal-free GMP growth factors and cytokines.
Specialized Matrices
Extracellular matrices play a crucial role in supporting stem cell growth and organoid culture. Our diverse portfolio of Cultrex™ extracellular matrices are carefully designed and optimized for specialized 2D and 3D applications, ensuring lot-to-lot consistency, minimal endotoxin levels, and consistent protein concentration and composition.
Explore Cultrex Extracellular Matrices
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Ensuring reliable, consistent, and precise cell line differentiation, while maintaining full traceability and regulatory compliance of raw materials, can be complex. Success starts with a trusted partner. We deliver a consistent supply of high-quality, qualified reagents, with over 90% of our products manufactured in-house to ensure supply continuity, rigorous quality control, and dependable access to the materials you need - exactly when you need them.
Featured Solutions
Tunable Cell Culture
Enable chemical reprogramming, targeted differentiation, and enhanced cryopreservation viability with our GMP Small Molecules. Designed with consistency, safety, and traceability in mind, they deliver high levels of bioactivity and minimal batch-to-batch variability.
One Tool for Complete Verification
Simplify your stem cell differentiation with our all-in-one StemXVivo® Differentiation Kits. Complete with growth factors, small molecules, and cell marker antibodies, these kits provide straightforward and validated procedures for inducing and verifying stem cell differentiation status.
Discover StemXVivo Differentiation Kits
Enhanced Stem Cell Analysis
Flow cytometry is a powerful method for detailed characterization, analysis, and isolation of stem cells and their derivatives. Our comprehensive portfolio of antibodies, reagents, and tools is designed to optimize your flow cytometry experiments, enabling you to investigate large cell populations at the single-cell level.
Explore Flow Cytometry Reagents
Quantitative Analysis
Gaining accurate, quantitative insight into stem cell differentiation signaling networks is essential yet challenging. Simple Western systems provide high throughput, flexible multiplexing, and unprecedented sensitivity and reproducibility for a complete understanding of stem cell biology.
Learn More About Simple Western
Resources
iPSC to Beta Islet Symposium
A panel of field experts comes together to discuss their research plus connect it back to those it will impact most.
Pancreatic Beta Islets App Note
Differentiate and characterize iPSC-derived, insulin-producing pancreatic beta islets with high efficiency and reproducibility.
iPSC to Neural Cells & Organoids
Watch on-demand to learn how iPSCs have changed neural research from Dr. Dan Cortes, iPSC Cell Culture Manager at HHMI.