Mesodermal Lineage Markers

Pluripotent stem cells undergo lineage restriction to form the three embryonic germ layers: ectoderm, mesoderm, and endoderm. Early mesoderm commitment arises from an epithelial to mesenchymal transition following which the specified mesodermal lineage cells migrate inward as gastrulation proceeds. Cells of the mesodermal lineage are fated to form the vascular and lymphatic systems, including hemangioblasts and multipotent mesenchymal stem cells capable of differentiating into multiple specified cell types.

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