14 results for "Voltage-gated Potassium Channel Blockers" in Products

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Voltage-gated Potassium Channel Blockers

Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming α-subunits contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

4-Aminopyridine

Catalog #: 0940
(2)
Citations (295)
Product Documents

Non-selective KV channel blocker

Alternate Names: 4-AP
Purity: ≥98%
Non-selective KV channel blocker

E-4031 dihydrochloride

Catalog #: 1808
(2)
Citations (24)
Product Documents

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

Chemical Name: N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
Purity: ≥98%
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

XE 991 dihydrochloride

Catalog #: 2000
(1)
Citations (1183)
Product Documents

Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents

Chemical Name: 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
Purity: ≥98%
Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents

Guangxitoxin 1E

Catalog #: 5676
(1)
Citations (7)
Product Documents

Potent Kv2.1 and Kv2.2 channel blocker

Purity: ≥95%
Potent Kv2.1 and Kv2.2 channel blocker

Dofetilide

Catalog #: 3757
(1)
Citations (19)
Product Documents

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

Alternate Names: Tikosyn,UK 68798
Chemical Name: 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane
Purity: ≥98%
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

Chromanol 293B

Catalog #: 1412
(1)
Citations (47)
Product Documents

IKs blocker. Also blocks ICFTR

Chemical Name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Purity: ≥98%
IKs blocker. Also blocks ICFTR

(-)-[3R,4S]-Chromanol 293B

Catalog #: 1475
Citations (6)
Product Documents

IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

Chemical Name: N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide
Purity: ≥98%
IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

Linopirdine dihydrochloride

Catalog #: 1999
(1)
Citations (268)
Product Documents

KV7 (KCNQ) channel blocker

Alternate Names: DuP 996
Chemical Name: 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride
Purity: ≥98%
KV7 (KCNQ) channel blocker

DPO-1

Catalog #: 2533
(1)
Citations (25)
Product Documents

Blocker of KV1.5 channel and IKur current

Alternate Names: Diphenyl phosphine oxide-1
Chemical Name: [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide
Purity: ≥98%
Blocker of KV1.5 channel and IKur current

UK 78282 hydrochloride

Catalog #: 3829
(1)
Citations (1)
Product Documents

Blocker of KV1.3 and KV1.4 channels

Chemical Name: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride
Purity: ≥98%
Blocker of KV1.3 and KV1.4 channels

JNJ 303

Catalog #: 3899
Citations (20)
Product Documents

Potent and selective IKs blocker

Chemical Name: 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide
Purity: ≥98%
Potent and selective IKs blocker

Psora 4

Catalog #: 4367
(1)
Citations (6)
Product Documents

Potent KV1.3 channel blocker

Chemical Name: 4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one
Purity: ≥98%
Potent KV1.3 channel blocker

HMR 1556

Catalog #: 5011
(1)
Citations (35)
Product Documents

Potent and selective Iks channel blocker

Chemical Name: N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide
Purity: ≥98%
Potent and selective Iks channel blocker

Azimilide dihydrochloride

Catalog #: 6318
(1)
Citations (1)
Product Documents

Kv11.1 (hERG) channel blocker

Chemical Name: 1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride
Purity: ≥97%
Kv11.1 (hERG) channel blocker
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