Human CDX2 Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (3)
Supplemental Products

Human CDX2 Antibody Summary

Species Reactivity
Detects human CDX2 in direct ELISAs and Western blots.
Polyclonal Goat IgG
Antigen Affinity-purified
E. coli-derived recombinant human CDX2
Accession # Q99626
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human CDX2
5-15 µg/mL
Immersion fixed BG01V human embryonic stem cells differentiated to trophectoderm using Mouse Embryonic Fibroblast (MEF) Conditioned Media (Catalog # AR005) with 10 ng/mL recombinant human FGF-basic (Catalog # 233-FB-025) and 100 ng/mL recombinant human BMP-4 (Catalog # 314-BP-010) for 7 days

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CDX2

Human CDX2 (Caudal type homeobox transcription factor 2) is a 37 kDa member of the caudal family of homeobox proteins. It is 313 amino acids (aa) in length and contains a 167 aa caudal-like activation domain (aa 13‑180), a DNA-binding homeodomain (aa 186‑245) and two short, poly-glutamine and -proline repeats. CDX2 can exist as a dimer and is regulated by phosphorylation of a 4(x)serine motif that promotes CDX2 degradation. CDX2 promotes intestinal patterning and development. While it is necessary but not sufficient for intestinal phenotype differentiation, it will block cell proliferation on its own. Over the amino acid range used for immunization, human CDX2 is 95% and 97% aa identical to mouse and canine CDX2, respectively.

Long Name
Caudal-type Homeobox Transcription Factor 2
Entrez Gene IDs
1045 (Human); 12591 (Mouse); 66019 (Rat)
Alternate Names
caudal type homeo box transcription factor 2; caudal type homeobox 2; Caudal-type homeobox protein 2; CDX2; CDX3; CDX-3; CDX3caudal type homeobox transcription factor 2; homeobox protein CDX-2

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Citations for Human CDX2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids
    Authors: AC Silva, OB Matthys, DA Joy, MA Kauss, V Natarajan, MH Lai, D Turaga, AP Blair, M Alexanian, BG Bruneau, TC McDevitt
    Cell Stem Cell, 2021;28(12):2137-2152.e6.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  2. Direct On-Chip Differentiation of Intestinal Tubules from Induced Pluripotent Stem Cells
    Authors: E Naumovska, G Aalderink, C Wong Valen, K Kosim, A Nicolas, S Brown, P Vulto, KS Erdmann, D Kurek
    Int J Mol Sci, 2020;21(14):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  3. Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer
    Authors: R Francis, H Guo, C Streutker, M Ahmed, T Yung, PB Dirks, HH He, TH Kim
    Sci Adv, 2019;5(12):eaax8898.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC


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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Goat IgG (H+L) Antibody


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