Human CRTH-2 Antibody
Human CRTH-2 Antibody Summary
Accession # Q9Y5Y4
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
CRTH-2, also known as GPR44, is a 7TM G protein-coupled receptor that is expressed by activated Th2 cells and eosinophils. CRTH-2 binds Prostaglandin D2 and induces chemotaxis of these cells in allergic and inflammatory immune responses. Human and mouse CRTH-2 share 78% amino acid sequence identity.
Citations for Human CRTH-2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Novel association between vasoactive intestinal peptide and CRTH2 receptor in recruiting eosinophils: a possible biochemical mechanism for allergic eosinophilic inflammation of the airways.
Authors: El-Shazly A, Begon D, Kustermans G, Arafa M, Dortu E, Henket M, Lefebvre P, Louis R, Delvenne P
J Biol Chem, 2013;288(2):1374-84.
Sample Types: Whole Cells
Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease.
Authors: Guo N, Baglole CJ, O'Loughlin CW, Feldon SE, Phipps RP
J. Biol. Chem., 2010;285(21):15794-804.
Sample Types: Cell Lysates
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