Human CRTH-2 Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (2)
Supplemental Products

Human CRTH-2 Antibody Summary

Species Reactivity
Detects human CRTH‑2. Stains human CRTH-2-transfected cells but not parental cells.
Monoclonal Mouse IgG2A Clone # 301108
Protein A or G purified from hybridoma culture supernatant
NS0 mouse myeloma cell line transfected with human CRTH-2
Accession # Q9Y5Y4
Lyophilized from a 0.2 μm filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Flow Cytometry
2.5 µg/106 cells
Human CD3+ peripheral blood lymphocytes
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CRTH-2

CRTH-2, also known as GPR44, is a 7TM G protein-coupled receptor that is expressed by activated Th2 cells and eosinophils. CRTH-2 binds Prostaglandin D2 and induces chemotaxis of these cells in allergic and inflammatory immune responses. Human and mouse CRTH-2 share 78% amino acid sequence identity.

Long Name
Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells
Entrez Gene IDs
11251 (Human); 14764 (Mouse); 309212 (Rat)
Alternate Names
CD294 antigen; CD294; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH2; CRTH-2; CRTH2chemoattractant receptor homologous molecule expressed on T helper type 2 cells; DL1R; DP2; G protein-coupled receptor 44; GPR44; PGD2R; PTGDR2; putative G-protein coupled receptor 44

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Citations for Human CRTH-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Novel association between vasoactive intestinal peptide and CRTH2 receptor in recruiting eosinophils: a possible biochemical mechanism for allergic eosinophilic inflammation of the airways.
    Authors: El-Shazly A, Begon D, Kustermans G, Arafa M, Dortu E, Henket M, Lefebvre P, Louis R, Delvenne P
    J Biol Chem, 2013;288(2):1374-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Blocking
  2. Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease.
    Authors: Guo N, Baglole CJ, O'Loughlin CW, Feldon SE, Phipps RP
    J. Biol. Chem., 2010;285(21):15794-804.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot


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Isotype Controls

Mouse IgG2A Isotype Control

Reconstitution Buffers

Secondary Antibodies

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