Human ER beta/NR3A2 Antibody

R&D Systems | Catalog # PP-PPZ0506-00

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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human, Mouse, Transgenic Mouse

Applications

Validated:

Western Blot, Immunoprecipitation

Cited:

Immunohistochemistry, Chromatin Immunoprecipitation (ChIP)

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # PPZ0506
View all ER beta/NR3A2 Primary Antibodies »

Product Specifications

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human ER beta/NR3A2 Antibody

Application
Recommended Usage

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 2 reviews rated 5 using PP-PPZ0506-00 in the following applications:

Formulation, Preparation, and Storage

Formulation

A liquid formulation in physiologic saline with 0.1% NaN3.

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: ER beta/NR3A2

Estrogen Receptor beta (ERβ,NR3A2) is a member of the steroid receptor family. The natural ligand for ER is the classical estrogenic compound 17β-estradiol. ERβ is expressed in the granulosa cell layer of primary, secondary and mature follicles in the ovary, in bone, bladder, uterus, testis, epididymis, gastrointestinal tract, kidney, breast, heart, vessel wall, immune system, lung, pituitary, hippocampus and hypothalamus. Roles for ERβ in the reproductive and cardiovascular systems have been reported, although these are the subject of conflicting reports. ERβ has been postulated to act primarily as a modulator of ERα function. ER&beta has been shown to form homodimers as well as heterodimers with ERα. Both ERα and ERβ can give rise to numerous isoforms.

Long Name

Estrogen Receptor beta

Alternate Names

ESR2, NR3A2

Entrez Gene IDs

2100 (Human)

Gene Symbol

ESR2

Additional ER beta/NR3A2 Products

Product Documents for Human ER beta/NR3A2 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human ER beta/NR3A2 Antibody

For research use only

Citations for Human ER beta/NR3A2 Antibody

Customer Reviews for Human ER beta/NR3A2 Antibody (2)

5 out of 5
2 Customer Ratings
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
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1 Stars
0%

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  • Human ER beta/NR3A2 Antibody
    Name: Anonymous
    Application: Immunohistochemistry
    Sample Tested: Ovary tissue
    Species: Human
    Verified Customer | Posted 09/16/2025
    heating pretreatment, x200 primary antibody
    Human ER beta/NR3A2 Antibody PP-PPZ0506-00
    Bio-Techne Response
    This review reflects a new species or application tested on a primary antibody.
  • Human ER beta/NR3A2 Antibody
    Name: Cecilia Williams
    Application: Immunohistochemistry
    Sample Tested: Cancer Tissue and Normal tissue
    Species: Human
    Verified Customer | Posted 08/15/2017
    The present antibody proved excellent for IHC (1:600 dilution) of formalin-fixed paraffin-embedded tissues and cells, Western blotting (1:1000) and IP as determined by comparing results from ERbeta-positive cells and ERbeta-negative cells, and corroborated by mass spectrometry. It was tested on a wide range of human normal tissues and cancer, and correlated to mRNA levels (RNA-seq). It stained the nucleus of granulosa cells of the normal ovary, testis, adrenal gland, tonsil, and lymphocytes in various tissues; tumor cells of granulosa cell tumors and a subset of malignant melanoma. See full article at Nature Communications (Andersson et al, 2017): https://www.nature.com/articles/ncomms15840
    Human ER beta/NR3A2 Antibody PP-PPZ0506-00

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FAQs

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Associated Pathways

TGF-beta Signaling Pathways TGF-beta Signaling Pathway Thumbnail