Human IL-24 Antibody
Human IL-24 Antibody Summary
Gln50-Leu206
Accession # Q2YHE5
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
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Cell Proliferation Induced by IL‑24 and Neutralization by Human IL‑24 Antibody. Recombinant Human IL‑24 (Catalog # 1965-IL) stimulates proliferation in the BaF3 mouse pro‑B cell line co-transfected with human IL‑20 R alpha and IL‑20 R beta in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL‑24 (2 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL‑24 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1965). The ND50 is typically 0.2-0.6 µg/mL.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-24
Interleukin 24 (IL-24), also known as mda-7 (melanoma differentiation associated gene-7), is a member of the IL-10 family of helical cytokines. The IL-24 gene encodes a precursor protein of 207 amino acids that contains a 48 amino acid (aa) signal sequence and an 18 kDa, 158 aa mature segment. There are three potential N-linked glycosylation sites, at least one of which is used. When secreted, IL-24 is a 35-40 kDa phosphorylated glycoprotein that apparently can exist as either a monomer or dimer. It is suggested that glycosylation is essential for activity. Mature human IL-24 shares 69% aa sequence identity with mouse and rat IL-24. Human IL-24 is also active in rodent systems. Cells known to express IL-24 include B cells, CD4+ T cells, NK cells, lymph node dendritic cells, monocytes, melanocytes, and melanoma cells. Functionally, IL-24 has diverse activities. At low concentrations on monocytes, it induces type I proinflammatory cytokines such as IFN-gamma, IL-1 beta, IL‑12, and TNF-alpha. At high concentrations, it is a strong inducer of apoptosis in tumor cells but not normal cells. IL-24 also has anti-angiogenic properties. It directly binds IL-24 receptors on endothelial cells, activating STAT3 and blocking their differentiation. IL-24 binds and signals through two heterodimeric receptor complexes. One complex is the combination of IL-20 R alpha and IL-20 R beta, which is shared with IL-19 and IL-20. The second complex is a combination of IL-22 R and IL-20 R beta, which is shared with IL-20.
- Jiang, H. et al. (1995) Oncogene 11:2477.
- Jiang, H. et al. (1996) Proc. Natl. Acad. Sci. USA 93:9160.
- Wang, M. et al. (2002) J. Biol Chem. 227:7341.
- Chada, S. et al. (2004) Int. Immunopharmacol. 4:649.
- Pestka, S. et al. (2004) Annu. Rev. Immunol. 22:929.
- Chen, J. et al. (2003) Molec. Ther. 8:220.
Product Datasheets
Citations for Human IL-24 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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Enhanced tumor growth inhibition by mesenchymal stem cells derived from iPSCs with targeted integration of interleukin24 into rDNA loci
Authors: B Liu, F Chen, Y Wu, X Wang, M Feng, Z Li, M Zhou, Y Wang, L Wu, X Liu, D Liang
Oncotarget, 2017;8(25):40791-40803.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
T cell-derived microvesicles induce mast cell production of IL-24: relevance to inflammatory skin diseases.
Authors: Shefler I, Pasmanik-Chor M, Kidron D, Mekori Y, Hershko A
J Allergy Clin Immunol, 2014;133(1):217-24.e1-3.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Expansion of parasite-specific CD4+ and CD8+ T cells expressing IL-10 superfamily cytokine members and their regulation in human lymphatic filariasis.
Authors: Anuradha R, George P, Hanna L, Kumaran P, Chandrasekaran V, Nutman T, Babu S
PLoS Negl Trop Dis, 2014;8(4):e2762.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Induction of phenotype modifying cytokines by FERMT1 mutations.
Authors: Heinemann A, He Y, Zimina E, Boerries M, Busch H, Chmel N, Kurz T, Bruckner-Tuderman L, Has C
Hum. Mutat., 2011;32(4):397-406.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells.
Authors: Maarof G, Bouchet-Delbos L, Gary-Gouy H, Durand-Gasselin I, Krzysiek R, Dalloul A
Blood, 2010;115(9):1718-26.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24.
Authors: Tahara I, Miyake K, Hanawa H, Kurai T, Hirai Y, Ishizaki M, Uchida E, Tajiri T, Shimada T
Mol. Ther., 2007;15(10):1805-11.
Species: Human
Sample Types: Plasma
Applications: ELISA Development
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