Human/Mouse/Rat HOMER1 Antibody

Catalog # Availability Size / Price Qty
Detection of Human HOMER1 by Western Blot.
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Product Details
Citations (1)
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Human/Mouse/Rat HOMER1 Antibody Summary

Species Reactivity
Human, Mouse, Rat
Detects human HOMER1 in direct ELISAs.
Monoclonal Mouse IgG2B Clone # 666241
Protein A or G purified from hybridoma culture supernatant
Synthetic peptide KFGQWADSRA corresponding to aa 73-82 of human HOMER1
Accession # Q86YM7
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

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Recommended Concentration
Western Blot
2 µg/mL
See below
Simple Western
20 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human HOMER1 antibody by Western Blot. View Larger

Detection of Human HOMER1 by Western Blot. Western blot shows lysates of human brain (cerebellum) tissue and IMR-32 human neuroblastoma cell line. PVDF membrane was probed with 2 µg/mL of Mouse Anti-HOMER1 Monoclonal Antibody (Catalog # MAB6889) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for HOMER1 at approximately 52 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 5.

Simple Western Detection of Human and Mouse HOMER1 antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Human and Mouse HOMER1 by Simple WesternTM. Simple Western lane view shows lysates of human brain (cerebellum) tissue, loaded at 0.2 mg/mL. A specific band was detected for HOMER1 at approximately 51 kDa (as indicated) using 20 µg/mL of Mouse Anti-Human/Mouse/Rat HOMER1 Monoclonal Antibody (Catalog # MAB6889). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Reconstitution Calculator

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Preparation and Storage

Sterile PBS to a final concentration of 0.5 mg/mL.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: HOMER1

HOMER1 is an approximately 48 kDa cytoplasmic protein that regulates the cell surface localization of neuronal mGluR1 and mGluR5 metabotropic glutamate receptors. It also functions in striated muscle mechanotransduction and excitation-contraction coupling by regulating the localization of transient receptor potential (TRP) channels and the coupling of ryanodine receptors to Cav1.2 calcium channels. Alternately spliced isoforms of human HOMER1 lack either the C-terminal half of the molecule (aa 178-354) or 130 aa following the WH1 domain (aa 99-228). Particular isoforms show distinct effects on hippocampal neuronal plasticity and the maintenance of extracellular glutamate levels in the prefrontal cortex. Within aa 73-82, human HOMER1 shares 100% aa sequence identity with mouse and rat HOMER1.

Long Name
Homer Protein Homolog 1
Entrez Gene IDs
9456 (Human); 26556 (Mouse)
Alternate Names
homer homolog 1 (Drosophila); HOMER; HOMER1; homer-1; HOMER1A; HOMER1B; HOMER-1B; HOMER1C; SYN47; SYN47neuronal immediate early gene, 1; Ves-1

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Citation for Human/Mouse/Rat HOMER1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice
    Authors: MK Schroeder, B Liu, RG Hinshaw, MA Park, S Wang, S Dubey, GG Liu, Q Shi, P Holton, V Reiser, PA Jones, W Trigg, MF Di Carli, BJ Caldarone, JP Williams, MK O'Banion, CA Lemere
    International Journal of Molecular Sciences, 2021;22(24):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot


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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

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